Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial compares the effect of adding olanzapine to standard of care symptom management for nausea to standard of care alone in managing an abnormal loss of the appetite for food (anorexia) in patients treated with chemoradiation therapy (CRT) for head and neck cancer. Patients undergoing CRT may experience treatment-related side effects, including pain, nausea, and a discomfort in the ability to speak, swallow and eat. These side effects have been shown to increase weight loss, opiate use and hospitalization. Olanzapine is a drug used to treat certain mental disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of anti-psychotic and a type of monoamine antagonist. Adding olanzapine to standard of care symptom management to limit nausea may be more effective than standard of care alone in managing anorexia in head and neck cancer patients during CRT.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek powyżej 18 lat
- •Potwierdzony biopsją rak płaskonabłonkowy głowy, szyi lub szyi z nieznanym ogniskiem pierwotnym
- •Kwalifikacja do chemioterapii i radioterapii w celu wyleczenia
- •Zdolność do połykania i przyjmowania leków doustnych
- •Kobiety w wieku rozrodczym muszą stosować antykoncepcję
- •Zgoda na unikanie alkoholu podczas przyjmowania olanzapiny
- •Zgoda na niejeżdżenie samochodem i nieuczestniczenie w operowaniu niebezpiecznych maszyn do czasu oceny bezpieczeństwa leku
- •Podpisana świadoma zgoda na uczestnictwo w badaniu
✗ Disqualifies
- •Kwalifikacja wyłącznie do paliatywnego leczenia (bez celu wyleczenia)
- •Pacjenci z rurką do żywienia
- •Regularne stosowanie steroidów
- •Obecne leczenie innymi lekami z grupy antypychotyków atypowych
- •Niekontrolowane infekcje lub poważne problemy kardiologiczne
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 18, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Roswell Park Cancer Institute
Buffalo, United States
Trial contact
Anurag K. Singh
Anurag K. Singh
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/19/2026.
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