The Vanguard Study: Testing a New Way to Screen for Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers in the blood in order to screen for multiple cancers simultaneously. There is a need to understand how MCDs may work as cancer screening tools. The goal of cancer screening is to reduce the burden of cancer by identifying cancers before they show symptoms or signs, when treatment is likely to be most effective. In this study, adults aged 45-75 without cancer will be randomly assigned to one of 3 groups: 2 separate MCD test groups or a control group. These two MCD tests will not be compared to each other but will be compared to cancers detected in the control group. This study will provide early information on how well MCD tests perform as cancer screening tools. It will also help researchers understand how patients and their doctors make decisions about their care when the MCD test result comes back as normal (negative) or abnormal (positive).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby w wieku od 45 do 75 lat
- •Zgoda na pobranie próbek krwi do badań
- •Zgoda na dostęp do informacji z dokumentacji medycznej
- •Zrozumienie i możliwość wypełnienia formularzy w języku angielskim, hiszpańskim lub arabskim
✗ Disqualifies
- •Diagnoza raka (guza litego lub krwi) w ciągu ostatnich 5 lat
- •Obecnie trwająca diagnostyka w kierunku raka
- •Udział w innym badaniu dotyczącym testów lub technologii do wykrywania raka
- •Karmienie piersią, ciąża lub planowanie ciąży w ciągu najbliższego roku
Simplified criteria — AI translation
Trial details
- Minimum age
- 45 Years
- Maximum age
- 75 Years
- Last updated (source)
- July 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (38)
Kaiser Permanente-Division of Research
Pleasanton, United States
Keefe Memorial Hospital
Cheyenne Wells, United States
Kaiser Permanente-Franklin
Denver, United States
Poudre Valley Hospital
Fort Collins, United States
Cancer Care and Hematology-Fort Collins
Fort Collins, United States
UCHealth Greeley Hospital
Greeley, United States
Kaiser Permanente-Rock Creek
Lafayette, United States
Kaiser Permanente-Lone Tree
Lone Tree, United States
Medical Center of the Rockies
Loveland, United States
Kaiser Permanente Moanalua Medical Center
Honolulu, United States
Walter Reed National Military Medical Center
Bethesda, United States
Henry Ford Cancer Institute-Downriver
Brownstown, United States
Henry Ford Health Center - Brownstown
Brownstown, United States
Henry Ford Health Center - Chesterfield
Chesterfield, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, United States
Henry Ford Medical Center-Fairlane
Dearborn, United States
Henry Ford Hospital
Detroit, United States
Henry Ford Medical Center - Detroit Northwest
Detroit, United States
Henry Ford Medical Center-Cottage
Grosse Pointe Farms, United States
Henry Ford Medical Center - Livonia
Livonia, United States
Henry Ford Medical Center-Columbus
Novi, United States
Henry Ford Medical Center - Plymouth
Plymouth, United States
Henry Ford Medical Center - Royal Oak
Royal Oak, United States
Henry Ford Medical Center
Sterling Heights, United States
Henry Ford Medical Center - Troy
Troy, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, United States
Henry Ford Wyandotte Hospital
Wyandotte, United States
Saint Luke's Hospital of Kansas City
Kansas City, United States
Washington University School of Medicine
St Louis, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Sentara Martha Jefferson Hospital
Charlottesville, United States
Inova Schar Cancer Institute
Fairfax, United States
Inova Fair Oaks Hospital
Fairfax, United States
Sentara Norfolk General Hospital
Norfolk, United States
VCU Massey Cancer Center at Stony Point
Richmond, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
VCU Community Memorial Health Center
South Hill, United States
Trial contact
Site Public Contact
Jeffrey Lee
PRINCIPAL_INVESTIGATOR
Site Public Contact
Linda S. Cook
PRINCIPAL_INVESTIGATOR
Site Public Contact
Debra P. Ritzwoller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Stacey Honda
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kristen Natale
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christine Neslund-Dudas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Timothy J. Pluard
PRINCIPAL_INVESTIGATOR
Site Public Contact
Aimee S. James
PRINCIPAL_INVESTIGATOR
Site Public Contact
Daniel S. Reuland
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mark Doescher
PRINCIPAL_INVESTIGATOR
Site Public Contact
John M. Sayles
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rebecca D. Kaltman
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Alexander H. Krist
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.