Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is being done to answer the following questions: Can we lower the chance of your gastric cancer from growing or spreading by administering paclitaxel chemotherapy directly into your abdominal cavity in addition to chemotherapy given through a vein in your arm? Will administering paclitaxel chemotherapy directly into your abdominal cavity, in addition to chemotherapy given through a vein in your arm help you live longer? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your gastric cancer. The usual approach is defined as care most people get for gastric cancer. If you decide to take part in this study, you will first receive a surgical procedure called a diagnostic laparoscopy. This will help the study doctors learn more about your gastric cancer. Laparoscopy is a minimally invasive surgery for which you will be placed under general anesthesia. Then the surgeon will make small incisions (5mm) on your belly through which a camera and thin instruments are introduced to evaluate the abdomen. This procedure takes about 1 hour to complete. Your study group will be assigned during the surgery. The study groups are described further in the 'What are the study groups?' section below. If you are placed into the study group 1, you will not have an intraperitoneal port (a small device which is placed under the skin and fat of your upper abdomen and a tube that is placed into the abdomen). If you are placed into the study group 2, you will have an intraperitoneal port placed. The reason is that in addition to standard chemotherapy, which is given through a vein in your arm, this port will be used to deliver the medication paclitaxel directly inside your abdomen when you are ready to start study treatment. It is important to know that you will not know your study group until after the surgery is over. This is because information that is learned during the surgery will help determine which study group you are put in. Once you have fully healed from this surgery, you will start study treatment. Depending on which study group you are assigned, you will either receive a standard chemotherapy regimen (the regimen will be chosen by you and your doctor) if you are in study group 1, or paclitaxel through a tube in your belly plus chemotherapy given through a vein in your arm if you are in study group 2. All participants will get treatment for three (3) months after which you will undergo reevaluation. If the disease is under control or responding to treatment, you may continue the assigned treatment until your disease gets worse, the side effects become too severe, or you may be offered a surgical procedure to remove the cancer if the amount of disease is low and can be completely removed as determined by a surgeon. There is a very small chance that during the laparoscopy surgical procedure, the doctor might find something called "intra-abdominal adhesions". These are areas where the stomach has healed previously and created scar tissue. If this scar tissue prevents the surgeon from being able to place a port in the correct area, you would be ineligible to receive the study treatment. If this happens, you may still receive standard of care therapy after your surgery, but you will not be able to continue on the study. If you have more questions about this, you can ask your surgeon or the study team to help. After you finish your study treatment, your doctor or study team will watch you for side effects. They will continue to follow your condition every three (3) months during the first two (2) years, then every six (6) months until year 5. You may be reevaluated with Chest/Abdomen/Pelvis scans every three-six (3-6) months for up to five (5) years if decided by your doctor.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony przez badanie histologiczne rak żołądka lub złączenia przełyku ze żołądkiem
- •Przebycie chemioterapii I linii przez minimum 3 miesiące, maksymalnie 6 miesięcy
- •Rejestracja do badania w ciągu 4 tygodni po ostatniej dawce chemioterapii I linii
- •Możliwość bezpiecznego wykonania procedury diagnostycznej i dalszego leczenia
- •Brak przeszkód zdrowotnych do wykonania badania laparoskopowego
✗ Disqualifies
- •Przerzuty do narządów wewnętrznych inne niż jajniki
- •Niedrożność jelita cienkog lub grubego (poza zwężeniem ujścia żołądka)
- •Masywny wylew płynu w jamie brzusznej
- •Rozległe przerzuty węzłów chłonnych w retroperitoneum
- •Historia poprzedniej operacji uniemożliwiająca diagnostyczną laparoskopię
- •Zaburzenia czynności serca lub poprzednie leczenie lekami kardiotropowymi
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 19, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (78)
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
Cedars-Sinai Medical Center
Los Angeles, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Stanford Cancer Institute Palo Alto
Palo Alto, United States
UCHealth University of Colorado Hospital
Aurora, United States
Smilow Cancer Hospital-Derby Care Center
Derby, United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, United States
Smilow Cancer Hospital Care Center - Guilford
Guilford, United States
Yale University
New Haven, United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, United States
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, United States
UF Health Cancer Institute - Gainesville
Gainesville, United States
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Northwestern University
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Northwestern Medicine Cancer Center Old Irving Park
Chicago, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
Northwestern Medicine Oak Brook
Oak Brook, United States
Memorial Hospital East
Shiloh, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
University Medical Center New Orleans
New Orleans, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
Henry Ford Hospital
Detroit, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, United States
West Michigan Cancer Center
Kalamazoo, United States
Mayo Clinic in Rochester
Rochester, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, United States
University of New Mexico Cancer Center
Albuquerque, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
East White Plains, United States
NYU Langone Hospital - Long Island
Mineola, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
University of North Carolina-Hillsborough Campus
Hillsborough, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Oregon Health and Science University
Portland, United States
Thomas Jefferson University Hospital
Philadelphia, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
UPMC-Passavant Hospital
Pittsburgh, United States
Smilow Cancer Hospital Care Center - Westerly
Westerly, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
Parkland Memorial Hospital
Dallas, United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Drexel Town Square Health Center
Oak Creek, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Marshfield Medical Center - Weston
Weston, United States
Trial contact
Site Public Contact
Maheswari Senthil
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alexandra Gangi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Byrne Lee
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sunnie S. Kim
PRINCIPAL_INVESTIGATOR
Site Public Contact
Raghav Sundar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lakshmi Balasubramanian
PRINCIPAL_INVESTIGATOR
Site Public Contact
Seth Concors
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Brett L. Ecker
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mecker G. Moller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Ramon Jin
PRINCIPAL_INVESTIGATOR
Site Public Contact
Prakash K. Pandalai
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kevin M. Sullivan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jeremy L. Davis
PRINCIPAL_INVESTIGATOR
Site Public Contact
Thomas Enzler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rupen Shah
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kathleen Y. Butler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Travis E. Grotz
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
George Z. Li
PRINCIPAL_INVESTIGATOR
Site Public Contact
Haejin In
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alissa Greenbaum
PRINCIPAL_INVESTIGATOR
Site Public Contact
Zachary J. Brown
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Ashwin Somasundaram
PRINCIPAL_INVESTIGATOR
Site Public Contact
Edward A. Levine
PRINCIPAL_INVESTIGATOR
Site Public Contact
Daniel Almquist
PRINCIPAL_INVESTIGATOR
Site Public Contact
Pamela W. Lu
PRINCIPAL_INVESTIGATOR
Site Public Contact
Divya Sood
PRINCIPAL_INVESTIGATOR
Site Public Contact
Nader Hanna
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mohammad Haroon A. Choudry
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Deepa Magge
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alex C. Kim
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Erin P. Ward
PRINCIPAL_INVESTIGATOR
Site Public Contact
Nataliya V. Uboha
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rohit Sharma
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ugwuji N. Maduekwe
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/20/2026.
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