Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti-PD-1 or anti-PD-L1 immunotherapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak nerkowokomórkowy w zaawansowanym stadium lub z przerzutami, którego nie da się usunąć operacyjnie, i który pierwotnie miał cechy jasnokomórkowe.
- •Pacjent jest w dobrym stanie ogólnym (punktacja KPS >= 80%).
- •Istnieje przynajmniej jedna widoczna zmiana chorobowa, którą można zmierzyć za pomocą tomografii komputerowej lub rezonansu magnetycznego, nieznajdująca się w obszarze wcześniej naświetlanym.
- •Narządy i szpik kostny działają prawidłowo (sprawdzone nie wcześniej niż tydzień przed włączeniem do badania).
- •Kobiety w wieku rozrodczym muszą mieć negatywny wynik testu ciążowego.
✗ Disqualifies
- •Pacjent wcześniej przyjmował leki z grupy inhibitorów HIF-2α lub kabozantynib.
- •Inne aktywne choroby nowotworowe w ciągu ostatniego roku (z wyjątkiem wyleczonych nowotworów miejscowych).
- •Utrzymujące się poważne działania niepożądane po poprzednim leczeniu nowotworów lub działania niepożądane stopnia 3 lub wyższego.
- •Niekontrolowane lub źle kontrolowane wysokie ciśnienie krwi (powyżej 150/90 mmHg mimo leczenia).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (134)
Research Site
Gilbert, United States
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Goodyear, United States
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Phoenix, United States
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Duarte, United States
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La Jolla, United States
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Los Angeles, United States
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Sacramento, United States
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San Diego, United States
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New Haven, United States
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Washington D.C., United States
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Jacksonville, United States
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Miami, United States
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Orlando, United States
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Atlanta, United States
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Atlanta, United States
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Newnan, United States
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Zion, United States
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Indianapolis, United States
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Louisville, United States
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Jefferson, United States
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Baltimore, United States
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Boston, United States
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Boston, United States
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Rochester, United States
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St Louis, United States
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Omaha, United States
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New Brunswick, United States
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Buffalo, United States
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Rochester, United States
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Chapel Hill, United States
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Durham, United States
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Cleveland, United States
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Portland, United States
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Monroeville, United States
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Charleston, United States
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Nashville, United States
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Nashville, United States
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Dallas, United States
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Lubbock, United States
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Salt Lake City, United States
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Charlottesville, United States
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Seattle, United States
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Box Hill, Australia
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Chermside, Australia
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Elizabeth Vale, Australia
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Frankston, Australia
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Heidelberg, Australia
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Hobart, Australia
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Kurralta Park, Australia
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Macquarie Park, Australia
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Saint Leonards, Australia
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Subiaco, Australia
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Westmead, Australia
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Montreal, Canada
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Sherbrooke, Canada
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Toronto, Canada
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Vancouver, Canada
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Brno-střed, Czechia
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Hradec, Czechia
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Prague, Czechia
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Angers, France
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Brest, France
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Caen, France
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Montpellier, France
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Paris, France
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Poitiers, France
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Rennes, France
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Strasbourg, France
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Villejuif, France
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Berlin, Germany
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Dresden, Germany
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Frankfurt, Germany
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Freiburg im Breisgau, Germany
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Halle, Germany
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Hanover, Germany
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Heidelberg, Germany
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Leipzig, Germany
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Marburg, Germany
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Rostock, Germany
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Ulm, Germany
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Milan, Italy
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Naples, Italy
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Rome, Italy
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Terni, Italy
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Verona, Italy
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Akita, Japan
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Fukuoka, Japan
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Kobe, Japan
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Matsuyama, Japan
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Osaka, Japan
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Amsterdam, Netherlands
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Maastricht, Netherlands
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Nijmegen, Netherlands
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Rotterdam, Netherlands
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Utrecht, Netherlands
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Zwolle, Netherlands
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Auckland, New Zealand
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Christchurch, New Zealand
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Hamilton, New Zealand
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Rotorua, New Zealand
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Krakow, Poland
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Otwock, Poland
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Poznan, Poland
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Rzeszów, Poland
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Skorzewo, Poland
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Tomaszów Mazowiecki, Poland
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Bucharest, Romania
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Craiova, Romania
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Suceava, Romania
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Timișoara, Romania
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Busan, South Korea
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Daejeon, South Korea
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Goyang, South Korea
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Seongnam, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Barcelona, Spain
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Córdoba, Spain
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Madrid, Spain
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Málaga, Spain
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Santander, Spain
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Seville, Spain
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Vigo, Spain
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Cambridge, United Kingdom
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Cottingham, United Kingdom
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Exeter, United Kingdom
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Glasgow, United Kingdom
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Leeds, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Preston, United Kingdom
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Southampton, United Kingdom
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Sutton, United Kingdom
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Truro, United Kingdom
Trial contact
Medical Director
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.
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