New bioMarkers tO straTIfy cOlorectal caNcer Referrals
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this observational study is to evaluate if a blood test for circulating progastrin (hPG80) and transposable elements (TEs) can accurately predict colorectal cancer (CRC) or polyps in adult patients referred to the 2-week wait (2WW) or Straight to Test (STT) pathways for suspected lower gastrointestinal cancer. The main questions it aims to answer are: Can plasma hPG80 levels accurately predict a diagnosis of CRC or polyps in patients undergoing standard 2WW investigations? Can transposable elements (TEs) in the plasma serve as predictive biomarkers for CRC diagnosis in these patients? What are the patient preferences for different diagnostic tests for CRC, particularly a blood-based test compared to more invasive methods? Participants will: Provide a 20ml blood sample during a routine hospital visit for their 2WW diagnostic test (e.g., colonoscopy, CT Colon). Undergo standard clinical investigations as determined by their treating clinicians. Have their final diagnosis (cancer, polyp, or normal) correlated with their plasma hPG80 levels. For a subset of 100 participants (25 with confirmed CRC, 75 non-cancer), have their plasma analyzed for circulating signatures using RNAseq and DNAseq. Complete an electronic post-study questionnaire to explore their preferences and experiences with different CRC diagnostic tests used within the 2WW pathway.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dorosły pacjent (powyżej 18 lat) skierowany na badania podejrzenia raka dolnego odcinka jelit
- •Pacjenci obu płci w wieku powyżej 18 lat
- •Zdolność do wyrażenia świadomej zgody na udział w badaniu
- •Ogólny stan zdrowia pozwalający na standardowe badania diagnostyczne
✗ Disqualifies
- •Wiek poniżej 18 lat
- •Pacjenci z niezleczonym rakiem innego narządu
- •Pacjenci z zapalną chorobą jelit
- •Pacjenci niezdolni do wyrażenia świadomej zgody lub ją odmawiający
- •Pacjenci z przewlekłą chorobą zapalną jelit w rodzinie lub rakiem jelita w rodzinie
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 12, 2026
- Sex
- No restrictions
Locations (1)
Barts Health NHS Trust
London, United Kingdom
Trial contact
Valentin Butnari, MBBS, MSc
Eleanor McAlees
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/13/2026.
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