Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to learn if histotripsy plus chemotherapy works to treat unresectable, bilobar liver- confined colorectal cancer liver metastasis (CRLM). The main question this clinical trial aims to answer is: • Does the management of this condition with uninterrupted palliative chemotherapy and histotripsy demonstrate improved progression-free survival? Participants will: * Receive chemotherapy treatment per standard procedure. * Undergo histotripsy treatment according to current standard procedures at Cleveland Clinic. * Occasionally receive Computerized Tomography (CT) scan with and without contrast, give biopsy of treated and untreated liver lesions, and participate in a blood draw of up to 3 teaspoons at each in-person visit. * Participate in genetic testing, as a part of the standard of care for the treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Przerzuty raka jelita grubego do wątroby, które nie można operacyjnie usunąć
- •Wiek 18 lat i więcej
- •Otrzymywanie chemioterapii pierwszej linii lub rozpoczęcie jej w ciągu 3 miesięcy
- •Możliwość poddania się znieczuleniu ogólnemu
- •Przeszłe leczenie wątroby (np. ablacja, embolizacja)
✗ Disqualifies
- •Przerzuty, które można usunąć chirurgicznie
- •Przerzuty poza wątrobą i płucami (np. do kości)
- •Niezdolność do tolerowania znieczulenia ogólnego
- •Zaawansowana marskość wątroby (klasa C)
- •Inne nowotwory w ciągu ostatnich 2 lat
- •Zbyt niski poziom białych krwinek
- •Ciąża
- •Wiek poniżej 18 lat
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, United States
Trial contact
Federico Aucejo, MD
Erlind Allkushi
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/16/2026.
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