A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The NSABP FC-13 study is being done to determine if using immunotherapies alone or in combination with other drugs will delay or prevent colorectal cancer from coming back in patients with colorectal cancer who are ctDNA-positive after their treatment. Immunotherapeutic drugs (immunotherapies) act on different proteins on the surface of cells of the immune system and trigger the immune system to destroy cancer cells. The drugs being studied in NSABP FC-13 are cemiplimab, fianlimab, and REGN7075.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Dobry stan ogólny (ECOG 0-1)
- •Potwierdzona operacyjnie II lub III stopień zaawansowania raka jelita grubego
- •Zupełne usunięcie guza pierwotnego i przerzutów (jeśli były)
- •Ukończona chemioterapia (co najmniej 3 miesiące)
- •Obecność śladów nowotworu w badaniu krwi (ctDNA) w ciągu 2 tygodni do 12 miesięcy po leczeniu
- •Potwierdzony typ nowotworu (MSS/pMMR)
- •Podpisana zgoda na uczestnictwo w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 3, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (13)
University of Florida
Gainesville, United States
University of Iowa - Holden Comprehensive Cancer Center
Iowa City, United States
University of Kansas Cancer Center
Kansas City, United States
University of Maryland Greenbaum
Baltimore, United States
Missouri Baptist
St Louis, United States
First Health of the Carolinas
Pinehurst, United States
Allegheny General Hospital
Pittsburgh, United States
Magee-Womens Hospital of UPMC
Pittsburgh, United States
Ballad Health Cancer Center - Kingsport
Kingsport, United States
Huntsman Cancer Institute - University of Utah
Salt Lake City, United States
University of Virginia Health
Charlottesville, United States
Bon Secours St. Francis Medical Center
Midlothian, United States
Virginia Commonwealth University - Massey
Richmond, United States
Trial contact
Department of Site and Study Management (DSSM)
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/4/2026.
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