Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests the effect of giving pembrolizumab in combination with radiation therapy after chemotherapy in preventing surgery to remove the bladder in patients with muscle invasive bladder cancer. Standard of care therapy includes chemotherapy before surgery (neoadjuvant) to shrink or get rid of the tumor. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Photon beam radiation therapy is a type of radiation therapy that uses x-rays or gamma rays that come from a special machine called a linear accelerator. The radiation dose is delivered at the surface of the body and goes into the tumor and through the body. Giving pembrolizumab in combination with radiation therapy after neoadjuvant chemotherapy may help prevent surgical removal of the bladder in patients with muscle invasive bladder cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak pęcherza o potwierdzonym badaniem histologicznym, który nacieka mięśnie (stadium cT2-T4aN0M0), zdiagnozowany w ciągu ostatnich 6 miesięcy przed leczeniem początkowym.
- •Przed rozpoczęciem leczenia początkowego wykonano badania obrazowe (np. TK, MRI, PET) pozwalające ocenić stadium raka.
- •Po zakończeniu leczenia początkowego wykonano zabieg TURBT (przezcewkowa resekcja guza pęcherza) z pobraniem wycinków, aby sprawdzić, czy nowotwór zniknął.
- •Wykonano badania obrazowe klatki piersiowej, jamy brzusznej i miednicy (np. TK, MRI, PET-TK) po zakończeniu leczenia początkowego.
✗ Disqualifies
- •Rak pęcherza, który po leczeniu początkowym nacieka głębiej niż na stadium T2, lub nacieka węzły chłonne (N1-3), lub dał przerzuty (M1).
- •Wykrycie raka o cechach małego komórkowego lub neuroendokrynnego, lub wariantu plazmacytoidalnego.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (159)
University of Alabama at Birmingham Cancer Center
Birmingham, United States
Banner MD Anderson Cancer Center
Gilbert, United States
Mayo Clinic Hospital in Arizona
Phoenix, United States
Highlands Oncology Group - Fayetteville
Fayetteville, United States
Highlands Oncology Group - Rogers
Rogers, United States
Highlands Oncology Group
Springdale, United States
Tower Cancer Research Foundation
Beverly Hills, United States
City of Hope Corona
Corona, United States
City of Hope Comprehensive Cancer Center
Duarte, United States
City of Hope at Irvine Lennar
Irvine, United States
City of Hope Antelope Valley
Lancaster, United States
Los Angeles General Medical Center
Los Angeles, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, United States
Cedars-Sinai Medical Center
Los Angeles, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
City of Hope South Pasadena
South Pasadena, United States
Cedars-Sinai Cancer - Tarzana
Tarzana, United States
City of Hope Upland
Upland, United States
UCHealth University of Colorado Hospital
Aurora, United States
UCHealth - Cherry Creek
Denver, United States
Shaw Cancer Center
Edwards, United States
Poudre Valley Hospital
Fort Collins, United States
Cancer Care and Hematology-Fort Collins
Fort Collins, United States
UCHealth Greeley Hospital
Greeley, United States
UCHealth Highlands Ranch Hospital
Highlands Ranch, United States
UCHealth Lone Tree Health Center
Lone Tree, United States
Medical Center of the Rockies
Loveland, United States
Mayo Clinic in Florida
Jacksonville, United States
Moffitt Cancer Center at SouthShore
Ruskin, United States
Moffitt Cancer Center-International Plaza
Tampa, United States
Moffitt Cancer Center - McKinley Campus
Tampa, United States
Moffitt Cancer Center
Tampa, United States
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel, United States
CTCA at Southeastern Regional Medical Center
Newnan, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
Rush-Copley Medical Center
Aurora, United States
OSF Saint Joseph Medical Center
Bloomington, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Illinois CancerCare-Carthage
Carthage, United States
Northwestern University
Chicago, United States
Carle at The Riverfront
Danville, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
Illinois CancerCare-Dixon
Dixon, United States
Carle Physician Group-Effingham
Effingham, United States
Crossroads Cancer Center
Effingham, United States
Illinois CancerCare-Eureka
Eureka, United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, United States
Illinois CancerCare-Galesburg
Galesburg, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, United States
Northwestern Medicine Glenview Outpatient Center
Glenview, United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, United States
Illinois CancerCare-Macomb
Macomb, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Northwestern Medicine Oak Brook
Oak Brook, United States
Northwestern Medicine Orland Park
Orland Park, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, United States
OSF Saint Francis Medical Center
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Carle Cancer Center
Urbana, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
Illinois CancerCare - Washington
Washington, United States
Mary Greeley Medical Center
Ames, United States
McFarland Clinic - Ames
Ames, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
McFarland Clinic - Boone
Boone, United States
Mercy Cancer Center-West Lakes
Clive, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, United States
McFarland Clinic - Jefferson
Jefferson, United States
McFarland Clinic - Marshalltown
Marshalltown, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
The Iowa Clinic PC
West Des Moines, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, United States
UofL Health Medical Center Northeast
Louisville, United States
University Medical Center New Orleans
New Orleans, United States
Ochsner Medical Center Jefferson
New Orleans, United States
Tufts Medical Center
Boston, United States
Dana-Farber Cancer Institute
Boston, United States
UMass Memorial Medical Center - University Campus
Worcester, United States
Sanford Joe Lueken Cancer Center
Bemidji, United States
Fairview Southdale Hospital
Edina, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
University of Mississippi Medical Center
Jackson, United States
Saint Francis Medical Center
Cape Girardeau, United States
Billings Clinic Cancer Center
Billings, United States
Community Medical Center
Missoula, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
Jefferson Cherry Hill Hospital
Cherry Hill, United States
Hunterdon Medical Center
Flemington, United States
Jersey City Medical Center
Jersey City, United States
Saint Barnabas Medical Center
Livingston, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, United States
Sidney Kimmel Cancer Center Washington Township
Sewell, United States
The New York Hospital Medical Center of Queens
Flushing, United States
NYP/Weill Cornell Medical Center
New York, United States
Stony Brook University Medical Center
Stony Brook, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, United States
University of Cincinnati Cancer Center-West Chester
West Chester, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Asplundh Cancer Pavilion
Willow Grove, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
The West Clinic - Wolf River
Germantown, United States
Parkland Memorial Hospital
Dallas, United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, United States
University of Texas Health Science Center at San Antonio
San Antonio, United States
Scott and White Memorial Hospital
Temple, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
Dartmouth Cancer Center - North
Saint Johnsbury, United States
VCU Massey Cancer Center at Stony Point
Richmond, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Swedish Medical Center-First Hill
Seattle, United States
West Virginia University Healthcare
Morgantown, United States
Camden Clark Medical Center
Parkersburg, United States
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
Appleton, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
Brookfield, United States
Ascension Calumet Hospital-Chilton
Chilton, United States
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
Franklin, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, United States
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
Mequon, United States
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
Milwaukee, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, United States
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
Oshkosh, United States
Ascension All Saints Hospital-Spring Street-Racine
Racine, United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
Wauwatosa, United States
Trial contact
Site Public Contact
Charles C. Peyton
PRINCIPAL_INVESTIGATOR
Site Public Contact
Chinedu Mmeje
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mark D. Tyson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joseph T. Beck
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Leslie Ballas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Abhishek Tripathi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Siamak Daneshmand
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Mamta Parikh
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Tyler Robin
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Erin Schwab
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
George D. Grass
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bamidele A. Adesunloye
PRINCIPAL_INVESTIGATOR
Site Public Contact
Priyank P. Patel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sean Sachdev
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Nicklas R. Pfanzelter
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
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Site Public Contact
Site Public Contact
Joseph J. Merchant
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Insija Ilyas Selene
PRINCIPAL_INVESTIGATOR
Site Public Contact
Scott R. Silva
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Rajasree P. Chowdry
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kyle Rose
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brett Diamond
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kent W. Mouw
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kriti Mittal
PRINCIPAL_INVESTIGATOR
Site Public Contact
Daniel Almquist
PRINCIPAL_INVESTIGATOR
Site Public Contact
David M. King
PRINCIPAL_INVESTIGATOR
Site Public Contact
John C. Henegan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
John M. Schallenkamp
PRINCIPAL_INVESTIGATOR
Site Public Contact
James B. Yu
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joseph M. Caster
PRINCIPAL_INVESTIGATOR
Site Public Contact
Myron E. Bednar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lara Hathout
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Leen Khoury
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rohit Jain
PRINCIPAL_INVESTIGATOR
Site Public Contact
Judy Huang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Bailey A. Nelson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kelly L. Stratton
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ronac Mamtani
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Daniel A. Vaena
PRINCIPAL_INVESTIGATOR
Site Public Contact
Suzanne M. Cole
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Daniel A. Hamstra
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Chul S. Ha
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lucas Wong
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bogdana Schmidt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Alfredo I. Urdaneta
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Charles W. Drescher
PRINCIPAL_INVESTIGATOR
Site Public Contact
Muhammad Mohsin Fareed
PRINCIPAL_INVESTIGATOR
Site Public Contact
Francis J. Cuevas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Matthew L. Ryan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.
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