A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to compare the clinical benefit of the combination of Navlimetostat (BMS-986504) (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Zaawansowany rak płuca (niedrobnokomórkowy) w stadium IV lub nawrotowy, bez wcześniejszego leczenia systemowego
- •Potwierdzona biopsją diagnoza raka płuca niedrobnokomórkowego z delecją lub utratą genu MTAP
- •Ogólny stan zdrowia: 0-1 w skali ECOG (móc wykonywać większość normalnych czynności)
- •Co najmniej jeden zmierzyć się dający się zmierzyć guz
✗ Disqualifies
- •Przerzuty do mózgu powodujące objawy lub ucisk na rdzeń kręgowy
- •Wcześniejsze leczenie systemowe (chemioterapia, immunoterapia, terapia celowana) zaawansowanego raka płuca
- •Problemy z połykaniem lub wchłanianiem leków w postaci tabletek
- •Pewne zmutacje genetyczne, dla których dostępna jest standardowa terapia pierwszego rzędu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 20, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (318)
Alaska Oncology and Hematology
Anchorage, United States
Mayo Clinic in Arizona - Phoenix
Phoenix, United States
University of Arizona Cancer Center
Tucson, United States
Highlands Oncology Group
Springdale, United States
Local Institution - 0497
Los Alamitos, United States
USC/Norris Comprehensive Cancer Center
Los Angeles, United States
Local Institution - 0444
Los Angeles, United States
Local Institution - 0606
Newark, United States
Helios Clinical Research - Fort Lauderdale
Fort Lauderdale, United States
Mayo Clinic in Florida
Jacksonville, United States
Local Institution - 0430
St. Petersburg, United States
Local Institution - 0523
Tampa, United States
St. Luke's Cancer Institute: Boise
Boise, United States
Local Institution - 0605
Decatur, United States
Baptist Health Lexington
Lexington, United States
University of Kentucky Chandler Medical Center
Lexington, United States
Local Institution - 0127
Scarborough, United States
Dana-Farber Cancer Institute
Boston, United States
Local Institution - 0418
Ann Arbor, United States
Local Institution - 0405
Detroit, United States
Local Institution - 0420
Traverse City, United States
Mayo Clinic in Rochester, Minnesota
Rochester, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
Omaha, United States
Local Institution - 0467
Lebanon, United States
Local Institution - 0600
Manchester, United States
WMCHealth Advanced Physician Services
Hawthorne, United States
Local Institution - 0128
Rochester, United States
Local Institution - 0518
Schenectady, United States
Local Institution - 0514
Winston-Salem, United States
Local Institution - 0163
Cleveland, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
Columbus, United States
Providence Portland Medical Center
Portland, United States
Kaiser Permanente Interstate Medical Office Central
Portland, United States
Local Institution - 0559
Hershey, United States
Local Institution - 0608
Greenville, United States
Local Institution - 0515
Knoxville, United States
Local Institution - 0433
Dallas, United States
Renovatio Clinical - El Paso
El Paso, United States
University of Texas MD Anderson Cancer Center
Houston, United States
Local Institution - 0377
The Woodlands, United States
Huntsman Cancer Institute
Salt Lake City, United States
Local Institution - 0131
Fairfax, United States
Virginia Commonwealth University
Richmond, United States
Fred Hutchinson Cancer Center
Seattle, United States
Hospital Británico de Buenos Aires
CABA, Argentina
Instituto Alexander Fleming
Ciudad Autónoma de Buenos Aires, Argentina
Local Institution - 0568
Lujan de Cuyo, Argentina
Local Institution - 0463
Rosario, Argentina
Local Institution - 0618
Rosario, Argentina
Centro Oncologico Korben
Buenos Aires, Argentina
Local Institution - 0472
Buenos Aires, Argentina
Local Institution - 0432
Liverpool, Australia
Local Institution - 0591
St Leonards, Australia
Sunshine Coast University Hospital
Birtinya, Australia
Princess Alexandra Hospital
Brisbane, Australia
Lyell McEwin Hospital
Elizabeth Vale, Australia
Royal Hobart Hospital
Hobart, Australia
Grampians Health
Ballarat Central, Australia
Local Institution - 0368
Garran, Australia
Ordensklinikum Linz GmbH Elisabethinen
Linz, Austria
Landeskrankenhaus Rankweil
Rankweil, Austria
Klinik Floridsdorf
Vienna, Austria
Antwerp University Hospital
Edegem, Belgium
Local Institution - 0225
Yvoir, Belgium
AZ Delta vzw
Roeselare, Belgium
UZ Brussel
Brussels, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium
Local Institution - 0077
Fortaleza, Brazil
CEDOES
Vitória, Brazil
Liga Norte Riograndense Contra o Câncer
Natal, Brazil
Local Institution - 0576
Porto Alegre, Brazil
Hospital Nossa Senhora da Conceição
Porto Alegre, Brazil
Local Institution - 0080
Santa Cruz do Sul, Brazil
Clínica de Oncologia Reichow
Blumenau, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, Brazil
NAIC - Instituto do Câncer
Bauru, Brazil
Centro de Pesquisa Sao Lucas
Campinas, Brazil
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
São Caetano do Sul, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, Brazil
A. C. Camargo Cancer Center
São Paulo, Brazil
Instituto Nacional de Câncer - INCA
Rio de Janeiro, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, Brazil
Local Institution - 0315
Panagyurishte, Bulgaria
Specialized Hospital for Active Treatment of Oncology - Haskovo
Haskovo, Bulgaria
Complex Oncology Center - Ruse EOOD
Rousse, Bulgaria
University Multidisciplinary Hospital for Active Treatment "St. Ekaterina"
Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment "Tsaritsa Yoanna-ISUL" EAD
Sofia, Bulgaria
Trakia Hospital
Stara Zagora, Bulgaria
Local Institution - 0473
Providencia, Chile
Local Institution - 0476
Recoleta, Chile
Local Institution - 0566
Antofagasta, Chile
Local Institution - 0475
Santiago, Chile
Local Institution - 0072
Hefei, China
Peking University People's Hospital
Beijing, China
Local Institution - 0049
Beijing, China
Local Institution - 0286
Beijing, China
Local Institution - 0621
Beijing, China
Local Institution - 0108
Chongqing, China
Fujian Cancer Hospital
Fuzhou, China
The First Affiliated hospital of Xiamen University
Xiamen, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, China
Guangdong Provincial People's Hospital
Guangzhou, China
Local Institution - 0061
Guangzhou, China
Local Institution - 0281
Shenzhen, China
Guangxi Medical University Affiliated Cancer Hospital
Nanning, China
Local Institution - 0408
Guiyang, China
Local Institution - 0353
Shijiazhuang, China
Local Institution - 0106
Harbin, China
Local Institution - 0107
Zhengzhou, China
Local Institution - 0047
Zhengzhou, China
Wuhan Union Hospital Cancer Center
Wuhan, China
Hubei Cancer Hospital
Wuhan, China
Local Institution - 0057
Changsha, China
Local Institution - 0387
Changsha, China
Local Institution - 0050
Changsha, China
Local Institution - 0352
Nanjing, China
Local Institution - 0279
Nanjing, China
Nanjing First Hospital
Nanjing, China
The First affiliated hospital of Nanchang University (Xianghu campus)
Nanchang, China
Local Institution - 0075
Changchun, China
Local Institution - 0284
Shenyang, China
Local Institution - 0104
Shenyang, China
Liaoning Cancer Hospital
Shenyang, China
Local Institution - 0060
Xi'an, China
Local Institution - 0051
Jinan, China
LinYi Cancer Hospital
Linyi, China
Local Institution - 0068
Qingdao, China
Shanghai Chest Hospital
Shanghai, China
Zhongshan Hospital,Fudan University
Shanghai, China
Local Institution - 0283
Taiyuan, China
Sichuan Cancer hospital
Chengdu, China
West China Hospital Sichuan University
Chengdu, China
The first Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
Local Institution - 0069
Hangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
Local Institution - 0330
Medellín, Colombia
Local Institution - 0305
Bogotá, Colombia
Local Institution - 0306
Montería, Colombia
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia
Local Institution - 0614
Ostrava, Czechia
Fakultni nemocnice Olomouc
Olomouc, Czechia
Local Institution - 0356
Copenhagen, Denmark
CHU Bordeaux Haut-Leveque
Pessac, France
Centre François Baclesse
Caen, France
Centre Georges François Leclerc
Dijon, France
Chu Jean Minjoz
Besançon, France
CHRU de Brest
Brest, France
CHU de Toulouse - Hopital Larrey
Toulouse, France
Local Institution - 0220
Montpellier, France
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, France
Local Institution - 0215
Saint-Herblain, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
Vandœuvre-lès-Nancy, France
Institut Paoli-Calmettes
Marseille, France
Chu Gabriel Montpied
Clermont-Ferrand, France
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, France
Local Institution - 0213
Créteil, France
Local Institution - 0599
Villejuif, France
Local Institution - 0583
Nice, France
Institut Curie
Paris, France
Local Institution - 0586
Reims, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, France
Groupe hospitalier Paris saint Joseph
Paris, France
Local Institution - 0461
Göppingen, Germany
Robert Bosch Krankenhaus GmbH
Stuttgart, Germany
Local Institution - 0580
Tübingen, Germany
Bundeswehrkrankenhaus Ulm
Ulm, Germany
Local Institution - 0617
Donauwörth, Germany
TUM Klinikum
München, Germany
Krankenhaus Barmherzige Brüder Regensburg
Regensburg, Germany
Pius Hospital Oldenburg
Oldenburg, Germany
Local Institution - 0551
Bonn, Germany
Local Institution - 0582
Hemer, Germany
Local Institution - 0198
Berlin, Germany
LungenClinic Grosshansdorf
Großhansdorf, Germany
Lungenfachklinik Immenhausen
Immenhausen, Germany
Klinik Löwenstein
Löwenstein, Germany
University Hospital of Patras
Pátrai, Greece
Errikos Dunant Hospital Center
Athens, Greece
Thoracic General Hospital of Athens "I Sotiria"
Athens, Greece
Alexandra General Hospital of Athens
Athens, Greece
"Theagenio" Cancer Hospital of Thessaloniki
Thessaloniki, Greece
Local Institution - 0585
Marousi, Greece
University General Hospital of Larissa
Larissa, Greece
Local Institution - 0481
Thessaloniki, Greece
Queen Mary Hospital
Hksar, Hong Kong
Local Institution - 0323
Shatin, Hong Kong
Local Institution - 0290
Gyula, Hungary
Local Institution - 0291
Gyöngyös, Hungary
Farkasgyepui Tudogyogyintezet
Farkasgyepű, Hungary
Local Institution - 0288
Budapest, Hungary
Local Institution - 0263
Bangalore, India
Local Institution - 0344
Bengaluru, India
Local Institution - 0345
Mumbai, India
Local Institution - 0266
Mumbai, India
Local Institution - 0620
Nashik, India
Local Institution - 0267
New Delhi, India
Local Institution - 0265
Hyderabad, India
Local Institution - 0264
Varanasi, India
Meir Medical Center
Kfar Saba, Israel
Sheba Medical Center
Ramat Gan, Israel
Local Institution - 0017
Jerusalem, Israel
Hadassah Medical Center
Jerusalem, Israel
Local Institution - 0016
Afula, Israel
Rambam Health Care Campus
Haifa, Israel
Local Institution - 0546
Beersheba, Israel
AOU della Campania Luigi Vanvitelli
Naples, Italy
Ospedale Santa Maria delle Croci
Ravenna, Italy
Cro-Irccs
Aviano, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Italy
Local Institution - 0485
Candiolo, Italy
Local Institution - 0486
Siena, Italy
AO Santa Maria della Misericordia
Perugia, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
Ospedale San Raffaele
Milan, Italy
Local Institution - 0483
Rome, Italy
Local Institution - 0468
Verona, Italy
Local Institution - 0243
Nagoya, Japan
Local Institution - 0236
Kashiwa, Japan
Local Institution - 0334
Otashi, Japan
Hokkaido University Hospital
Sapporo, Japan
Local Institution - 0336
Himeji, Japan
Local Institution - 0247
Kobe, Japan
Local Institution - 0335
Shiwa-gun Yahaba-cho, Japan
Local Institution - 0257
Kawasaki, Japan
Local Institution - 0238
Yokohama, Japan
Local Institution - 0241
Nankoku, Japan
Local Institution - 0237
Matsusaka, Japan
Local Institution - 0232
Sendai, Japan
Local Institution - 0240
Hirakata, Japan
Local Institution - 0245
Hidaka, Japan
Local Institution - 0235
Shimotsuga, Japan
Local Institution - 0234
Bunkyo-ku, Japan
Local Institution - 0242
Ube, Japan
Local Institution - 0246
Fukuoka, Japan
National Hospital Organization Okayama Medical Center
Okayama, Japan
Osaka City General Hospital
Osaka, Japan
University Malaya Medical Centre
Lembah Pantai, Malaysia
Local Institution - 0390
Kuching, Malaysia
Cancer Treamtent Clinic and Clinical Trials Sa de Cv
Guadalajara, Mexico
Local Institution - 0610
Guadalajara, Mexico
Local Institution - 0326
Guadalajara, Mexico
Local Institution - 0615
Zapopan, Mexico
Local Institution - 0294
Mexico City, Mexico
Local Institution - 0609
Mexico City, Mexico
Local Institution - 0624
Monterrey, Mexico
Local Institution - 0298
Monterrey, Mexico
Local Institution - 0297
Oaxaca City, Mexico
Local Institution - 0327
Chihuahua City, Mexico
CENEIT Oncologicos
Mexico City, Mexico
Local Institution - 0331
Puebla City, Mexico
Local Institution - 0328
Querétaro, Mexico
Local Institution - 0574
Heerlen, Netherlands
Local Institution - 0445
Veldhoven, Netherlands
Local Institution - 0230
Arnhem, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Local Institution - 0096
Drammen, Norway
Local Institution - 0604
Elverum, Norway
Local Institution - 0603
Oslo, Norway
Centrum Medyczne Pratia Poznań
Poznan, Poland
Local Institution - 0259
Krakow, Poland
Local Institution - 0612
Jelenia Góra, Poland
Local Institution - 0594
Warsaw, Poland
Local Institution - 0261
Warsaw, Poland
Local Institution - 0458
Wieliszew, Poland
Szpital Specjalistyczny w Prabutach Spolka z o.o.
Prabuty, Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka
Bydgoszcz, Poland
Local Institution - 0607
Oradea, Romania
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
Bucharest, Romania
Local Institution - 0619
Cluj-Napoca, Romania
SC Radiotherapy Center Cluj SRL
Florești, Romania
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Romania
Radiology Therapeutic Center
Otopeni, Romania
Centrul de Diagnostic si Tratament Provita
Bucharest, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
S.C. Centrul de Oncologie Euroclinic S.R.L.
Iași, Romania
Institutul Regional de Oncologie
Iași, Romania
Spitalul Municipal Schuller Ploiești
Ploieşti, Romania
Chungbuk National University Hospital
Cheongju-si, South Korea
National Cancer Center
Goyang-si, South Korea
Seoul National University Bundang Hospital
Seongnam, South Korea
Local Institution - 0571
Suwon, South Korea
Local Institution - 0270
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Local Institution - 0573
Seoul, South Korea
Local Institution - 0471
Seoul, South Korea
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Local Institution - 0248
Hospitalet, Spain
Local Institution - 0253
Barcelona, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain
Local Institution - 0480
Madrid, Spain
H.R.U Málaga - Hospital General
Málaga, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Local Institution - 0255
Valencia, Spain
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden
Chi Mei Hospital - Liouying Branch
Tainan, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Medical University Hospital
Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, Taiwan
Local Institution - 0411
Bangkok, Thailand
Local Institution - 0412
Bangkok, Thailand
Local Institution - 0349
Izmir, Karsiyaka, Turkey (Türkiye)
Local Institution - 0318
Adana, Turkey (Türkiye)
Local Institution - 0317
Adana, Turkey (Türkiye)
Local Institution - 0321
Ankara, Turkey (Türkiye)
Local Institution - 0593
Ankara, Turkey (Türkiye)
Local Institution - 0350
Antalya, Turkey (Türkiye)
Local Institution - 0320
Bursa, Turkey (Türkiye)
Local Institution - 0319
Edirne, Turkey (Türkiye)
Local Institution - 0595
Istanbul, Turkey (Türkiye)
Leicester Royal Infirmary
Leicester, United Kingdom
Sarah Cannon Research Institute UK
London, United Kingdom
Trial contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
First line of the email MUST contain NCT # and Site #.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.