RecruitingPhase II/III🇵🇱 PolandEN originalLung cancerMetastatic / advanced

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The purpose of this study is to compare the clinical benefit of the combination of Navlimetostat (BMS-986504) (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Zaawansowany rak płuca (niedrobnokomórkowy) w stadium IV lub nawrotowy, bez wcześniejszego leczenia systemowego
  • Potwierdzona biopsją diagnoza raka płuca niedrobnokomórkowego z delecją lub utratą genu MTAP
  • Ogólny stan zdrowia: 0-1 w skali ECOG (móc wykonywać większość normalnych czynności)
  • Co najmniej jeden zmierzyć się dający się zmierzyć guz

✗ Disqualifies

  • Przerzuty do mózgu powodujące objawy lub ucisk na rdzeń kręgowy
  • Wcześniejsze leczenie systemowe (chemioterapia, immunoterapia, terapia celowana) zaawansowanego raka płuca
  • Problemy z połykaniem lub wchłanianiem leków w postaci tabletek
  • Pewne zmutacje genetyczne, dla których dostępna jest standardowa terapia pierwszego rzędu

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 20, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (318)

Alaska Oncology and Hematology

Anchorage, United States

Mayo Clinic in Arizona - Phoenix

Phoenix, United States

University of Arizona Cancer Center

Tucson, United States

Highlands Oncology Group

Springdale, United States

Local Institution - 0497

Los Alamitos, United States

USC/Norris Comprehensive Cancer Center

Los Angeles, United States

Local Institution - 0444

Los Angeles, United States

Local Institution - 0606

Newark, United States

Helios Clinical Research - Fort Lauderdale

Fort Lauderdale, United States

Mayo Clinic in Florida

Jacksonville, United States

Local Institution - 0430

St. Petersburg, United States

Local Institution - 0523

Tampa, United States

St. Luke's Cancer Institute: Boise

Boise, United States

Local Institution - 0605

Decatur, United States

Baptist Health Lexington

Lexington, United States

University of Kentucky Chandler Medical Center

Lexington, United States

Local Institution - 0127

Scarborough, United States

Dana-Farber Cancer Institute

Boston, United States

Local Institution - 0418

Ann Arbor, United States

Local Institution - 0405

Detroit, United States

Local Institution - 0420

Traverse City, United States

Mayo Clinic in Rochester, Minnesota

Rochester, United States

Oncology Hematology West P.C. dba Nebraska Cancer Specialists

Omaha, United States

Local Institution - 0467

Lebanon, United States

Local Institution - 0600

Manchester, United States

WMCHealth Advanced Physician Services

Hawthorne, United States

Local Institution - 0128

Rochester, United States

Local Institution - 0518

Schenectady, United States

Local Institution - 0514

Winston-Salem, United States

Local Institution - 0163

Cleveland, United States

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center

Columbus, United States

Providence Portland Medical Center

Portland, United States

Kaiser Permanente Interstate Medical Office Central

Portland, United States

Local Institution - 0559

Hershey, United States

Local Institution - 0608

Greenville, United States

Local Institution - 0515

Knoxville, United States

Local Institution - 0433

Dallas, United States

Renovatio Clinical - El Paso

El Paso, United States

University of Texas MD Anderson Cancer Center

Houston, United States

Local Institution - 0377

The Woodlands, United States

Huntsman Cancer Institute

Salt Lake City, United States

Local Institution - 0131

Fairfax, United States

Virginia Commonwealth University

Richmond, United States

Fred Hutchinson Cancer Center

Seattle, United States

Hospital Británico de Buenos Aires

CABA, Argentina

Instituto Alexander Fleming

Ciudad Autónoma de Buenos Aires, Argentina

Local Institution - 0568

Lujan de Cuyo, Argentina

Local Institution - 0463

Rosario, Argentina

Local Institution - 0618

Rosario, Argentina

Centro Oncologico Korben

Buenos Aires, Argentina

Local Institution - 0472

Buenos Aires, Argentina

Local Institution - 0432

Liverpool, Australia

Local Institution - 0591

St Leonards, Australia

Sunshine Coast University Hospital

Birtinya, Australia

Princess Alexandra Hospital

Brisbane, Australia

Lyell McEwin Hospital

Elizabeth Vale, Australia

Royal Hobart Hospital

Hobart, Australia

Grampians Health

Ballarat Central, Australia

Local Institution - 0368

Garran, Australia

Ordensklinikum Linz GmbH Elisabethinen

Linz, Austria

Landeskrankenhaus Rankweil

Rankweil, Austria

Klinik Floridsdorf

Vienna, Austria

Antwerp University Hospital

Edegem, Belgium

Local Institution - 0225

Yvoir, Belgium

AZ Delta vzw

Roeselare, Belgium

UZ Brussel

Brussels, Belgium

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

Liège, Belgium

Local Institution - 0077

Fortaleza, Brazil

CEDOES

Vitória, Brazil

Liga Norte Riograndense Contra o Câncer

Natal, Brazil

Local Institution - 0576

Porto Alegre, Brazil

Hospital Nossa Senhora da Conceição

Porto Alegre, Brazil

Local Institution - 0080

Santa Cruz do Sul, Brazil

Clínica de Oncologia Reichow

Blumenau, Brazil

Fundação Pio XII - Hospital de Câncer de Barretos

Barretos, Brazil

NAIC - Instituto do Câncer

Bauru, Brazil

Centro de Pesquisa Sao Lucas

Campinas, Brazil

Centro de Oncologia - CEON+ - Unidade São Caetano do Sul

São Caetano do Sul, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto

São José do Rio Preto, Brazil

A. C. Camargo Cancer Center

São Paulo, Brazil

Instituto Nacional de Câncer - INCA

Rio de Janeiro, Brazil

Icesp - Instituto Do Câncer Do Estado de São Paulo

São Paulo, Brazil

Local Institution - 0315

Panagyurishte, Bulgaria

Specialized Hospital for Active Treatment of Oncology - Haskovo

Haskovo, Bulgaria

Complex Oncology Center - Ruse EOOD

Rousse, Bulgaria

University Multidisciplinary Hospital for Active Treatment "St. Ekaterina"

Sofia, Bulgaria

University Multiprofile Hospital for Active Treatment "Tsaritsa Yoanna-ISUL" EAD

Sofia, Bulgaria

Trakia Hospital

Stara Zagora, Bulgaria

Local Institution - 0473

Providencia, Chile

Local Institution - 0476

Recoleta, Chile

Local Institution - 0566

Antofagasta, Chile

Local Institution - 0475

Santiago, Chile

Local Institution - 0072

Hefei, China

Peking University People's Hospital

Beijing, China

Local Institution - 0049

Beijing, China

Local Institution - 0286

Beijing, China

Local Institution - 0621

Beijing, China

Local Institution - 0108

Chongqing, China

Fujian Cancer Hospital

Fuzhou, China

The First Affiliated hospital of Xiamen University

Xiamen, China

The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, China

Guangdong Provincial People's Hospital

Guangzhou, China

Local Institution - 0061

Guangzhou, China

Local Institution - 0281

Shenzhen, China

Guangxi Medical University Affiliated Cancer Hospital

Nanning, China

Local Institution - 0408

Guiyang, China

Local Institution - 0353

Shijiazhuang, China

Local Institution - 0106

Harbin, China

Local Institution - 0107

Zhengzhou, China

Local Institution - 0047

Zhengzhou, China

Wuhan Union Hospital Cancer Center

Wuhan, China

Hubei Cancer Hospital

Wuhan, China

Local Institution - 0057

Changsha, China

Local Institution - 0387

Changsha, China

Local Institution - 0050

Changsha, China

Local Institution - 0352

Nanjing, China

Local Institution - 0279

Nanjing, China

Nanjing First Hospital

Nanjing, China

The First affiliated hospital of Nanchang University (Xianghu campus)

Nanchang, China

Local Institution - 0075

Changchun, China

Local Institution - 0284

Shenyang, China

Local Institution - 0104

Shenyang, China

Liaoning Cancer Hospital

Shenyang, China

Local Institution - 0060

Xi'an, China

Local Institution - 0051

Jinan, China

LinYi Cancer Hospital

Linyi, China

Local Institution - 0068

Qingdao, China

Shanghai Chest Hospital

Shanghai, China

Zhongshan Hospital,Fudan University

Shanghai, China

Local Institution - 0283

Taiyuan, China

Sichuan Cancer hospital

Chengdu, China

West China Hospital Sichuan University

Chengdu, China

The first Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, China

Local Institution - 0069

Hangzhou, China

Zhejiang Cancer Hospital

Hangzhou, China

Local Institution - 0330

Medellín, Colombia

Local Institution - 0305

Bogotá, Colombia

Local Institution - 0306

Montería, Colombia

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia

Local Institution - 0614

Ostrava, Czechia

Fakultni nemocnice Olomouc

Olomouc, Czechia

Local Institution - 0356

Copenhagen, Denmark

CHU Bordeaux Haut-Leveque

Pessac, France

Centre François Baclesse

Caen, France

Centre Georges François Leclerc

Dijon, France

Chu Jean Minjoz

Besançon, France

CHRU de Brest

Brest, France

CHU de Toulouse - Hopital Larrey

Toulouse, France

Local Institution - 0220

Montpellier, France

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou

Rennes, France

Local Institution - 0215

Saint-Herblain, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois

Vandœuvre-lès-Nancy, France

Institut Paoli-Calmettes

Marseille, France

Chu Gabriel Montpied

Clermont-Ferrand, France

Hospices Civils de Lyon - Hopital Louis Pradel

Bron, France

Local Institution - 0213

Créteil, France

Local Institution - 0599

Villejuif, France

Local Institution - 0583

Nice, France

Institut Curie

Paris, France

Local Institution - 0586

Reims, France

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau

Tours, France

Groupe hospitalier Paris saint Joseph

Paris, France

Local Institution - 0461

Göppingen, Germany

Robert Bosch Krankenhaus GmbH

Stuttgart, Germany

Local Institution - 0580

Tübingen, Germany

Bundeswehrkrankenhaus Ulm

Ulm, Germany

Local Institution - 0617

Donauwörth, Germany

TUM Klinikum

München, Germany

Krankenhaus Barmherzige Brüder Regensburg

Regensburg, Germany

Pius Hospital Oldenburg

Oldenburg, Germany

Local Institution - 0551

Bonn, Germany

Local Institution - 0582

Hemer, Germany

Local Institution - 0198

Berlin, Germany

LungenClinic Grosshansdorf

Großhansdorf, Germany

Lungenfachklinik Immenhausen

Immenhausen, Germany

Klinik Löwenstein

Löwenstein, Germany

University Hospital of Patras

Pátrai, Greece

Errikos Dunant Hospital Center

Athens, Greece

Thoracic General Hospital of Athens "I Sotiria"

Athens, Greece

Alexandra General Hospital of Athens

Athens, Greece

"Theagenio" Cancer Hospital of Thessaloniki

Thessaloniki, Greece

Local Institution - 0585

Marousi, Greece

University General Hospital of Larissa

Larissa, Greece

Local Institution - 0481

Thessaloniki, Greece

Queen Mary Hospital

Hksar, Hong Kong

Local Institution - 0323

Shatin, Hong Kong

Local Institution - 0290

Gyula, Hungary

Local Institution - 0291

Gyöngyös, Hungary

Farkasgyepui Tudogyogyintezet

Farkasgyepű, Hungary

Local Institution - 0288

Budapest, Hungary

Local Institution - 0263

Bangalore, India

Local Institution - 0344

Bengaluru, India

Local Institution - 0345

Mumbai, India

Local Institution - 0266

Mumbai, India

Local Institution - 0620

Nashik, India

Local Institution - 0267

New Delhi, India

Local Institution - 0265

Hyderabad, India

Local Institution - 0264

Varanasi, India

Meir Medical Center

Kfar Saba, Israel

Sheba Medical Center

Ramat Gan, Israel

Local Institution - 0017

Jerusalem, Israel

Hadassah Medical Center

Jerusalem, Israel

Local Institution - 0016

Afula, Israel

Rambam Health Care Campus

Haifa, Israel

Local Institution - 0546

Beersheba, Israel

AOU della Campania Luigi Vanvitelli

Naples, Italy

Ospedale Santa Maria delle Croci

Ravenna, Italy

Cro-Irccs

Aviano, Italy

Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano, Italy

Local Institution - 0485

Candiolo, Italy

Local Institution - 0486

Siena, Italy

AO Santa Maria della Misericordia

Perugia, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola

Bologna, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Italy

Ospedale San Raffaele

Milan, Italy

Local Institution - 0483

Rome, Italy

Local Institution - 0468

Verona, Italy

Local Institution - 0243

Nagoya, Japan

Local Institution - 0236

Kashiwa, Japan

Local Institution - 0334

Otashi, Japan

Hokkaido University Hospital

Sapporo, Japan

Local Institution - 0336

Himeji, Japan

Local Institution - 0247

Kobe, Japan

Local Institution - 0335

Shiwa-gun Yahaba-cho, Japan

Local Institution - 0257

Kawasaki, Japan

Local Institution - 0238

Yokohama, Japan

Local Institution - 0241

Nankoku, Japan

Local Institution - 0237

Matsusaka, Japan

Local Institution - 0232

Sendai, Japan

Local Institution - 0240

Hirakata, Japan

Local Institution - 0245

Hidaka, Japan

Local Institution - 0235

Shimotsuga, Japan

Local Institution - 0234

Bunkyo-ku, Japan

Local Institution - 0242

Ube, Japan

Local Institution - 0246

Fukuoka, Japan

National Hospital Organization Okayama Medical Center

Okayama, Japan

Osaka City General Hospital

Osaka, Japan

University Malaya Medical Centre

Lembah Pantai, Malaysia

Local Institution - 0390

Kuching, Malaysia

Cancer Treamtent Clinic and Clinical Trials Sa de Cv

Guadalajara, Mexico

Local Institution - 0610

Guadalajara, Mexico

Local Institution - 0326

Guadalajara, Mexico

Local Institution - 0615

Zapopan, Mexico

Local Institution - 0294

Mexico City, Mexico

Local Institution - 0609

Mexico City, Mexico

Local Institution - 0624

Monterrey, Mexico

Local Institution - 0298

Monterrey, Mexico

Local Institution - 0297

Oaxaca City, Mexico

Local Institution - 0327

Chihuahua City, Mexico

CENEIT Oncologicos

Mexico City, Mexico

Local Institution - 0331

Puebla City, Mexico

Local Institution - 0328

Querétaro, Mexico

Local Institution - 0574

Heerlen, Netherlands

Local Institution - 0445

Veldhoven, Netherlands

Local Institution - 0230

Arnhem, Netherlands

University Medical Center Groningen

Groningen, Netherlands

Local Institution - 0096

Drammen, Norway

Local Institution - 0604

Elverum, Norway

Local Institution - 0603

Oslo, Norway

Centrum Medyczne Pratia Poznań

Poznan, Poland

Local Institution - 0259

Krakow, Poland

Local Institution - 0612

Jelenia Góra, Poland

Local Institution - 0594

Warsaw, Poland

Local Institution - 0261

Warsaw, Poland

Local Institution - 0458

Wieliszew, Poland

Szpital Specjalistyczny w Prabutach Spolka z o.o.

Prabuty, Poland

Centrum Onkologii im. Prof. Franciszka Lukaszczyka

Bydgoszcz, Poland

Local Institution - 0607

Oradea, Romania

Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"

Bucharest, Romania

Local Institution - 0619

Cluj-Napoca, Romania

SC Radiotherapy Center Cluj SRL

Florești, Romania

Centrul de Oncologie "Sfântul Nectarie"

Craiova, Romania

Radiology Therapeutic Center

Otopeni, Romania

Centrul de Diagnostic si Tratament Provita

Bucharest, Romania

Institutul Oncologic Cluj

Cluj-Napoca, Romania

Institutul Oncologic Cluj

Cluj-Napoca, Romania

S.C. Centrul de Oncologie Euroclinic S.R.L.

Iași, Romania

Institutul Regional de Oncologie

Iași, Romania

Spitalul Municipal Schuller Ploiești

Ploieşti, Romania

Chungbuk National University Hospital

Cheongju-si, South Korea

National Cancer Center

Goyang-si, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Local Institution - 0571

Suwon, South Korea

Local Institution - 0270

Seoul, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Local Institution - 0573

Seoul, South Korea

Local Institution - 0471

Seoul, South Korea

Hospital Universitari Vall d'Hebron

Barcelona, Spain

Local Institution - 0248

Hospitalet, Spain

Local Institution - 0253

Barcelona, Spain

Hospital General Universitario Gregorio Marañon

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Spain

Local Institution - 0480

Madrid, Spain

H.R.U Málaga - Hospital General

Málaga, Spain

Hospital Universitario Virgen Del Rocio

Seville, Spain

Local Institution - 0255

Valencia, Spain

Sahlgrenska Universitetssjukhuset

Gothenburg, Sweden

Chi Mei Hospital - Liouying Branch

Tainan, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Medical University Hospital

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch

Taoyuan, Taiwan

Local Institution - 0411

Bangkok, Thailand

Local Institution - 0412

Bangkok, Thailand

Local Institution - 0349

Izmir, Karsiyaka, Turkey (Türkiye)

Local Institution - 0318

Adana, Turkey (Türkiye)

Local Institution - 0317

Adana, Turkey (Türkiye)

Local Institution - 0321

Ankara, Turkey (Türkiye)

Local Institution - 0593

Ankara, Turkey (Türkiye)

Local Institution - 0350

Antalya, Turkey (Türkiye)

Local Institution - 0320

Bursa, Turkey (Türkiye)

Local Institution - 0319

Edirne, Turkey (Türkiye)

Local Institution - 0595

Istanbul, Turkey (Türkiye)

Leicester Royal Infirmary

Leicester, United Kingdom

Sarah Cannon Research Institute UK

London, United Kingdom

Trial contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

First line of the email MUST contain NCT # and Site #.

Contact information from ClinicalTrials.gov. Contact in English.

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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.

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