A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study will evaluate the safety, efficacy, optimal dose, and pharmacokinetics (PK) of BNT326 as monotherapy (Part 1) and as combination treatment with immunotherapeutic agents (Part 2) in participants with histologically or cytologically confirmed solid tumors that are advanced (i.e., either metastatic or recurrent tumors with no further definitive treatment possible) and/or have relapsed/progressed after prior therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony zaawansowany nowotwór (przerzutowy lub nawracający) udokumentowany badaniem histologicznym lub cytologicznym
- •Mierzalne zmiany nowotworowe
- •Dobry stan ogólny (ECOG 0 lub 1)
- •Prawidłowa funkcja narządów i szpiku kostnego
- •W czerniaków: wcześniejsze leczenie lekami hamującymi PD-1 lub PD-L1 oraz (jeśli wymagane) lekami celowanymi na mutacje BRAF
- •W raku płuca: zaawansowana choroba niedająca się radykalnie leczyć
- •W raku płuca bez mutacji: brak zmian genetycznych, dla których dostępne są terapie celowane
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (67)
Mayo Clinic Arizona
Phoenix, United States
University of California San Francisco
San Francisco, United States
Hartford Healthcare
Hartford, United States
Yale University
New Haven, United States
Florida Cancer Specialists
Sarasota, United States
Moffitt Cancer Center
Tampa, United States
Dana Farber Cancer Institute
Boston, United States
Massachusetts General Hospital
Boston, United States
Brigitte Harris Cancer Pavilion BHCP
Detroit, United States
START Midwest, LLC
Grand Rapids, United States
Memorial Sloan Kettering Hospital
New York, United States
Duke Cancer Institute
Durham, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, United States
University of Pittsburgh Medical Center
Pittsburgh, United States
The University of Texas MD Anderson Cancer Center
Houston, United States
South Texas Accelerated Research Therapeutics (START), LLC
San Antonio, United States
START Mountain Region
West Valley City, United States
The Board of Regents of the University of Wisconsin
Madison, United States
Blacktown Hospital
Blacktown, Australia
St Vincent's Hospital Sydney
Darlinghurst, Australia
Melanoma Institute Australia
Wollstonecraft, Australia
Tasman Oncology Research Ltd
Southport, Australia
Cancer Research SA
Adelaide, Australia
Peninsula and South Eastern Haematology & Oncology Group
Frankston, Australia
Austin Health
Heidelberg, Australia
The Alfred Hospital
Melbourne, Australia
One Clinical Research Pty Ltd
Nedlands, Australia
Universitair Ziekenhuis Gent
Ghent, Belgium
Centre hospitalier universitaire de Liège
Liège, Belgium
Ziekenhuis Aan de Stroom ZAS vzw
Wilrijk, Belgium
Charité - Campus Charité Mitte
Berlin, Germany
Universitaetsklinikum Essen
Essen, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, Germany
Klinikum der Universität München Campus Grosshadern
München, Germany
Universitätsklinikum Tübingen
Tübingen, Germany
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
Meldola, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
IEO Istituto Europeo di Oncologia
Milan, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
Istituto Clinico Humanitas
Rozzano, Italy
Hospital Universitari Vall d'Hebron - VHIO
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
START Barcelona -HM Nou Delfos
Barcelona, Spain
Hospital de San Pedro
Logroño, Spain
Hospital Beata Maria Ana
Madrid, Spain
Hospital Clinico San Carlos
Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
Centro Integral Oncologico Clara Campal
Madrid, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Spain
Hospital Universitari i Politecnic La Fe
Valencia, Spain
Dr. Abdurrahman Yurtaslan Ankara Oncology Traning & Research
Ankara, Turkey (Türkiye)
Hacettepe Oncology Hospital
Ankara, Turkey (Türkiye)
Ankara Bilkent City Hospital Phase 1 Clinical Research Cente
Ankara, Turkey (Türkiye)
Yeditepe University Kosuyolu Hospital
Istanbul, Turkey (Türkiye)
Queen Elizabeth Hospital
Birmingham, United Kingdom
Velindre Cancer Centre
Cardiff, United Kingdom
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
The Clatterbridge Cancer Centre
Liverpool, United Kingdom
Royal Free Hospital
London, United Kingdom
Royal Marsden Hospital-London
London, United Kingdom
Imperial College London
London, United Kingdom
University College London Hospitals
London, United Kingdom
The Christie Hospital
Manchester, United Kingdom
Northern Centre for Cancer Care
Newcastle upon Tyne, United Kingdom
Southampton General Hospital
Southampton, United Kingdom
Royal Marsden Hospital
Sutton, United Kingdom
Trial contact
BioNTech clinical trials patient information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.