RecruitingPhase IIEN originalLymphoma

A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (APEX-06)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This is a single-arm, multi-center, open-label, phase 2 study to evaluate the efficacy and safety of ICP-248 in subjects with relapsed or refractory mantle cell lymphoma.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek 18 lat lub więcej
  • Potwierdzony chłoniak z komórek płaszcza z mutacją Cyclin D1 lub translokacją t(11;14)
  • Wcześniejsze niepowodzenie co najmniej jednej linii terapii zawierającej anty-CD20
  • Wcześniejsze niepowodzenie co najmniej jednej linii terapii zawierającej inhibitor BTK
  • Brak odpowiedzi na ostatnią otrzymaną terapię
  • Co najmniej jeden zmierzalny guz widoczny w badaniach obrazowych
  • Ogólny stan zdrowia pozwalający na uczestnictwo (skala ECOG 0-2)

✗ Disqualifies

  • Historia chłoniaka w ośrodkowym układzie nerwowym
  • Wcześniejsze leczenie inhibitorami BCL-2 (np. venetoclax)
  • Przeszczep autologicznych komórek macierzystych lub terapia komórkowa w ciągu 3 miesięcy przed badaniem
  • Przeszczep allogenniczny szpiku kostnego w przeszłości

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 23, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (29)

The First Affiliated Hospital of Anhui Medical University

Hefei, China

Peking University Third Hospital

Beijing, China

West China Hospital of Sichuan University

Chengdu, China

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

Chongqing University Cancer Hospital

Chongqing, China

Fujian Medical University Union Hospital

Fuzhou, China

Sun Yat-sen University Cancer Center

Guangzhou, China

Guangdong Provincial People's Hospital

Guangzhou, China

Guangxi Medical University Cancer Hospital

Nanning, China

Henan Cancer Hospital

Zhengzhou, China

Henan Provincial People's Hospital

Zhengzhou, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, China

Hunan Cancer Hospital

Changsha, China

The First Affiliated Hospital of University of South China

Hengyang, China

Jiangsu Province Hospital

Nanjing, China

The First Affiliated Hospital of Nanchang University

Nanchang, China

The First Hospital of Jilin University

Changchun, China

Qilu Hospital of Shandong University

Jinan, China

Shandong Provincial Hospital Affiliated to Shandong First Medical University

Jinan, China

Shandong Cancer Hospital

Jinan, China

The Affiliated Hospital of Qingdao University

Qingdao, China

Fudan University Shanghai Cancer Center

Shanghai, China

The Second Affiliated Hospital of Xi'an Jiaotong University

Xian, China

Sichuan Provincial People's Hospital

Chengdu, China

The Second People's Hospital of Yibin

Yibin, China

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences

Tianjin, China

The Affiliated Cancer Hospital of Xinjiang Medical University

Xinjiang, China

The First Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, China

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/24/2026.

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