Mazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The LIGHT-COG study is a 76-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial evaluating the efficacy and safety of mazdutide in 420 participants with type 2 diabetes (T2D) and early-stage cognitive impairment, defined as mild cognitive impairment (MCI) or mild dementia. Participants are randomized 1:1 to receive once-weekly subcutaneous mazdutide, with dose escalation according to the protocol, or matching placebo, in addition to background glucose-lowering therapy. The primary objective is to determine whether 76 weeks of mazdutide treatment can slow cognitive and functional decline compared with placebo in this population.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznana cukrzyca typu 2
- •Wiek 50-75 lat
- •Wczesne zaburzenia pamięci lub myślenia (łagodne zaburzenia poznawcze lub łagodna demencja)
- •Stabilna kontrola poziomu cukru we krwi przez ostatnie 3 miesiące
- •Poziom HbA1c (średnia cukru z ostatnich 3 miesięcy) między 7,0 a 9,0%
- •Waga stabilna przez ostatnie 3 miesiące (zmiana mniejsza niż 5%)
- •Stała terapia problemów z pamięcią przez co najmniej 3 miesiące
- •Zgoda na uczestnictwo i możliwość wykonania testów pamięci
✗ Disqualifies
- •Podejrzenie innych chorób neurodegeneracyjnych, które mogą powodować zaburzenia pamięci
- •Inne warunki zdrowotne mogące zakłócić ocenę zaburzeń poznawczych
Simplified criteria — AI translation
Trial details
- Minimum age
- 50 Years
- Maximum age
- 75 Years
- Last updated (source)
- September 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (8)
Department of Endocrinology, Xiangya Hospital of Central South University
Changsha, China
Department of Endocrinology, Changzhou No.2 People's Hospital
Changzhou, China
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University
Nanjing, China
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Nanjing, China
Department of Endocrinology, Jiangsu Province Hospital of Traditional Chinese Medicine
Nanjing, China
The Second Affiliated Hospital of Dalian Medical University
Dalian, China
Department of Endocrinology, Shanghai General Hospital
Shanghai, China
Department of Endocrinology, Huadong Hospital Affiliated to Fudan University
Shanghai, China
Trial contact
Yan Bi, MD, PhD
Zhou Zhang, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/3/2026.
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