A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of the study is to explore the safety and effects of the study drug (PF-08046876) in people diagnosed with advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas. PF-08046876 is an investigational anticancer therapy called an 'antibody drug conjugate' or 'ADC'. ADCs are anticancer drugs designed to stick to cancer cells and kill them. The study drug will be given to participants through a needle in a vein (intravenous infusion). This study includes multiple parts. In the first part of the study, there will be different groups of people receiving different doses of the study drug. The study may also test different schedules.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Zaawansowany rak pęcherza, płuc, głowy i szyi, przełyku lub trzustki
- •Możliwość zmierzenia zmian nowotworowych
- •Ogólny stan zdrowia odpowiedni do udziału (ECOG 0-1)
- •Rak powrócił lub zmienił się po wcześniejszych leczeniach
- •Ustąpienie objawów ubocznych z poprzedniego leczenia
- •Zgoda na dostarczenie próbki guza przed rozpoczęciem badania
✗ Disqualifies
- •Wcześniejsze leczenie podobnym lekiem (z camptotecyną)
- •Brak apetytu, nudności, wymioty lub objawy niedrożności jelit
- •Poważne choroby płuc
- •Inne poważne zaburzenia zdrowia dyskwalifikujące z badania
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (30)
City of Hope National Medical Center
Duarte, United States
City of Hope at Irvine Lennar
Irvine, United States
Ronald Reagan UCLA Medical Center
Los Angeles, United States
UCLA Department of Medicine-Hematology/Oncology
Los Angeles, United States
Santa Monica UCLA Medical Center & Orthopaedic Hospital
Santa Monica, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, United States
Smilow Cancer Hospital - Yale New Haven Health
New Haven, United States
Yale - New Haven Hospital - Yale Cancer Center
New Haven, United States
Smilow Cancer Hospital Phase 1 Unit
New Haven, United States
Smilow Cancer Hospital - Trumbull
Trumbull, United States
Brigham and Women's Hospital
Boston, United States
Dana-Farber Cancer Institute
Boston, United States
Dana-Farber Cancer Institute - Chestnut Hill
Newton, United States
Sarah Cannon Research Institute - Pharmacy
Nashville, United States
SCRI Oncology Partners
Nashville, United States
The University of Texas MD Anderson Cancer Center - Conroe
Conroe, United States
University of Texas MD Anderson Cancer Center
Houston, United States
The University of Texas, MD Anderson Cancer Center - West Houston
Houston, United States
The University of Texas, MD Anderson Cancer Center - League City
League City, United States
NEXT Oncology
San Antonio, United States
The University of Texas, MD Anderson Cancer Center - Sugar Land
Sugar Land, United States
Princess Margaret Cancer Centre
Toronto, Canada
Princess Margaret Cancer Centre
Toronto, Canada
McGill University Health Centre
Montreal, Canada
Pan American Center for Oncology Trials, LLC
Rio Piedras, Puerto Rico
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Barts Cancer Centre at St. Bartholomew's Hospital; Queen Mary University of London
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Trial contact
Pfizer CT.gov Call Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.