RecruitingPhase II/III🇵🇱 PolandEN originalLung cancerMetastatic / advanced

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Pacjenci z niedrobnokomórkowym rakiem płuca, który nie nadaje się do leczenia przyczynowego.
  • Potwierdzona mutacja EGFR (np. delecja w eksonie 19, mutacja L858R).
  • Choroba postępuje mimo stosowania leczenia ukierunkowanego na EGFR (tzw. terapii celowanych), jako ostatniej metody leczenia.
  • Pacjenci mogą otrzymać chemioterapię opartą na platynie w połączeniu z pemetreksedem.

✗ Disqualifies

  • Niewydolność narządów lub szpiku kostnego.
  • Przerzuty do opon mózgowo-rdzeniowych lub ucisk rdzenia kręgowego.
  • Niekontrolowane choroby ogólnoustrojowe.
  • Inne kryteria wykluczenia określone w protokole badania.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 29, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (186)

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care building

Irvine, United States

University of California, Irvine (UCI) Health - UC Irvine Medical Center

Orange, United States

Shaw Cancer Center

Edwards, United States

Local Institution - 0085

Gainesville, United States

Local Institution - 0142

Pembroke Pines, United States

Piedmont Healthcare

Atlanta, United States

John B Amos Cancer Center

Columbus, United States

Rush University Medical Center

Chicago, United States

Dana-Farber Cancer Institute

Boston, United States

Washington University School of Medicine

St Louis, United States

Renown Regional Medical Center

Reno, United States

Perlmutter Cancer Center at NYU Langone Hospital - Long Island

Mineola, United States

NYU Langone Health

New York, United States

Weill Cornell Medical College

New York, United States

Rochester General Hospital Infectious Disease

Rochester, United States

University Hospitals Cleveland Medical Center

Cleveland, United States

Local Institution - 0284

Columbus, United States

Providence Cancer Institute Franz Clinic

Portland, United States

Providence St. Vincent Medical Center

Portland, United States

Oregon Health and Science University

Portland, United States

Hospital of the University of Pennsylvania

Philadelphia, United States

West Penn Allegheny Health

Pittsburgh, United States

Local Institution - 0268

Chattanooga, United States

Tennessee Oncology

Nashville, United States

Local Institution - 0025

Houston, United States

Local Institution - 0173

San Antonio, United States

University of Virginia Health System

Charlottesville, United States

Virginia Commonwealth University (Vcu)

Richmond, United States

Instituto Alexander Fleming

Ciudad Autónoma de Buenos Aires, Argentina

Local Institution - 0004

ABB, Argentina

Hospital Privado Universitario de Córdoba

Córdoba, Argentina

Local Institution - 0280

Wilrijk, Belgium

Local Institution - 0161

Auderghem, Belgium

Local Institution - 0022

Yvoir, Belgium

Local Institution - 0023

Ghent, Belgium

Local Institution - 0024

Sint-Niklaas, Belgium

Arthur J. E. Child Comprehensive Cancer Centre

Calgary, Canada

Princess Margaret Cancer Centre

Toronto, Canada

Local Institution - 0184

Chicoutimi, Canada

Local Institution - 0185

Montreal, Canada

Local Institution - 0006

Santiago, Chile

Local Institution - 0005

Santiago, Chile

Local Institution - 0007

Santiago, Chile

Local Institution - 0244

Beijing, China

Local Institution - 0259

Chongqing, China

Fujian Cancer Hospital

Fuzhou, China

Jiangmen Center Hospital

Jiangmen, China

Local Institution - 0271

Anyang, China

Local Institution - 0261

Luoyang, China

Local Institution - 0267

Jingzhou, China

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology

Wuhan, China

Local Institution - 0255

Changsha, China

Local Institution - 0256

Xuzhou, China

Local Institution - 0247

Nanchang, China

Local Institution - 0246

Changchun, China

Local Institution - 0257

Shenyang, China

Local Institution - 0248

Jinan, China

Local Institution - 0250

Shanghai, China

Local Institution - 0249

Shanghai, China

Shanxi Cancer Hospital

Taiyuan, China

Local Institution - 0252

Hangzhou, China

Local Institution - 0251

Linhai, China

Local Institution - 0260

Nanning, China

Local Institution - 0229

Valledupar, Colombia

Local Institution - 0228

Bogotá, Colombia

Local Institution - 0227

Montería, Colombia

Local Institution - 0226

Cali, Colombia

Local Institution - 0014

Strasbourg, France

Local Institution - 0017

Toulouse, France

Local Institution - 0010

Lille, France

Local Institution - 0018

La Tronche, France

Local Institution - 0170

Saint-Herblain, France

Local Institution - 0162

Bron, France

Local Institution - 0019

Villejuif, France

Local Institution - 0012

Marseille, France

Local Institution - 0278

Nantes, France

Local Institution - 0011

Paris, France

Local Institution - 0015

Paris, France

Local Institution - 0207

Esslingen am Neckar, Germany

Local Institution - 0238

Esslingen am Neckar, Germany

Local Institution - 0212

Stuttgart, Germany

Local Institution - 0236

Donauwörth, Germany

Local Institution - 0209

Oldenburg, Germany

Local Institution - 0213

Cologne, Germany

Local Institution - 0208

Chemnitz, Germany

Local Institution - 0274

Kiel, Germany

Local Institution - 0211

Berlin, Germany

Local Institution - 0215

Gauting, Germany

Local Institution - 0242

Hamburg, Germany

Local Institution - 0210

Heidelberg, Germany

Local Institution - 0239

Kassel, Germany

Local Institution - 0241

Ulm, Germany

Local Institution - 0054

Athens, Greece

Local Institution - 0060

Chaïdári, Greece

Local Institution - 0056

Thessaloniki, Greece

Local Institution - 0062

Thessaloniki, Greece

Local Institution - 0083

Ahmedabad, India

Local Institution - 0073

Ahmedabad, India

Local Institution - 0072

Gurugram, India

Local Institution - 0069

Bengaluru, India

Local Institution - 0077

Mumbai, India

Local Institution - 0071

Mumbai, India

Local Institution - 0097

Nagpur, India

Local Institution - 0070

New Delhi, India

Local Institution - 0078

Howrah, India

Local Institution - 0028

Ravenna, Italy

Local Institution - 0036

Aviano, Italy

Local Institution - 0031

Orbassano, Italy

Local Institution - 0277

Candiolo, Italy

Local Institution - 0137

Avellino, Italy

Local Institution - 0032

Milan, Italy

Local Institution - 0034

Naples, Italy

Local Institution - 0029

Parma, Italy

Local Institution - 0196

Nagoya, Japan

Local Institution - 0191

Kashiwa, Japan

Local Institution - 0203

Tōon, Japan

Local Institution - 0201

Kurume, Japan

Local Institution - 0217

Sapporo, Japan

Local Institution - 0199

Nishinomiya, Japan

Local Institution - 0193

Yokohama, Japan

Local Institution - 0192

Sendai, Japan

Local Institution - 0200

Kurashiki, Japan

Local Institution - 0198

Hirakata, Japan

Local Institution - 0204

Ōsaka-sayama, Japan

Local Institution - 0194

Ina-machi, Japan

Local Institution - 0197

Hamamatsu, Japan

Local Institution - 0195

Nagaizumi-cho,Sunto-gun, Japan

Local Institution - 0202

Koto-ku, Japan

Local Institution - 0225

Mexico City, Mexico

Local Institution - 0224

Oaxaca City, Mexico

Local Institution - 0222

Chihuahua City, Mexico

Local Institution - 0223

Mexico City, Mexico

Local Institution - 0163

Harderwijk, Netherlands

Local Institution - 0216

Amsterdam, Netherlands

Local Institution - 0164

Amsterdam, Netherlands

Local Institution - 0103

Drammen, Norway

Local Institution - 0106

Bergen, Norway

Local Institution - 0105

Oslo, Norway

Local Institution - 0220

Lublin, Poland

Local Institution - 0231

Gdynia, Poland

Local Institution - 0219

Bydgoszcz, Poland

Local Institution - 0120

Bucharest, Romania

Local Institution - 0123

Bucharest, Romania

Local Institution - 0132

Florești, Romania

Local Institution - 0130

Craiova, Romania

Local Institution - 0115

Bucharest, Romania

Local Institution - 0133

Cluj-Napoca, Romania

Local Institution - 0124

Iași, Romania

Local Institution - 0119

Iași, Romania

Local Institution - 0263

Singapore, Singapore

Local Institution - 0262

Singapore, Singapore

Local Institution - 0089

Cheongju-si, South Korea

Local Institution - 0043

Goyang-si, South Korea

Local Institution - 0044

Seongnam, South Korea

Local Institution - 0046

Suwon, South Korea

Local Institution - 0095

Seoul, South Korea

Local Institution - 0045

Seoul, South Korea

Local Institution - 0092

Seoul, South Korea

Local Institution - 0042

Seoul, South Korea

Local Institution - 0218

Barcelona, Spain

Local Institution - 0177

Barcelona, Spain

Local Institution - 0175

Madrid, Spain

Local Institution - 0206

Madrid, Spain

Local Institution - 0176

Madrid, Spain

Local Institution - 0181

Majadahonda, Spain

Local Institution - 0178

Málaga, Spain

Local Institution - 0182

Seville, Spain

Local Institution - 0180

Valencia, Spain

Local Institution - 0179

Zaragoza, Spain

Kantonsspital Baden

Baden, Switzerland

Cantonal Hospital St.Gallen

Sankt Gallen, Switzerland

Local Institution - 0189

Bellinzona, Switzerland

E-Da hospital

Kaohsiung City, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Medical University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Local Institution - 0265

Bangkok, Thailand

Local Institution - 0272

Mueng, Thailand

Local Institution - 0264

Bangkok, Thailand

Local Institution - 0266

Songkhla, Thailand

Local Institution - 0110

Glasgow, United Kingdom

Local Institution - 0061

London, United Kingdom

Local Institution - 0140

London, United Kingdom

Local Institution - 0281

Sulton, Surrey, United Kingdom

Trial contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

First line of the email MUST contain NCT # and Site #.

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/31/2026.

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