RecruitingPhase IIEN original

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

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This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The purpose of this study is to see if zanidatamab is safe and effective, when combined with chemotherapy, in treating people who has Human Epidermal Growth Factor Receptor 2 (HER2)-positive, early-stage breast cancer

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Rak piersi w stadium II lub III, potwierdzony badaniem histologicznym
  • Rak piersi dodatni na HER2, potwierdzony badaniem histologicznym
  • Znany status receptorów hormonalnych guza pierwotnego
  • Zgoda na poddanie się operacji piersi (całkowitej lub oszczędzającej) po chemioterapii przed operacją
  • Dobry ogólny stan zdrowia (ECOG 0 lub 1)
  • Prawidłowe funkcjonowanie organów wewnętrznych
  • Funkcja serca na poziomie co najmniej 50% (badanie echokardiograficzne lub MUGA)
  • Zastosowanie odpowiednich środków antykoncepcyjnych

✗ Disqualifies

  • Rak piersi w stadium IV (przerzuty odległe)
  • Rak piersi obustronny
  • Poważne problemy zdrowotne lub stany mogące wpłynąć na udział w badaniu
  • Niekontrolowane wysokie ciśnienie krwi
  • Znaczące objawy uszkodzenia nerwów (neuropatia)
  • Aktywna niekontrolowana infekcja
  • Historia ciężkich alergicznych reakcji na przeciwciała monoklonalne lub białka
  • Aktywne zakaźenie wirusem hepatitis B lub C

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 2, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (30)

Oncology Institute

Long Beach, United States

Cancer & Blood Research Center

Los Alamitos, United States

Rocky Mountain Cancer Centers

Denver, United States

Holy Cross Hospital

Fort Lauderdale, United States

The Oncology Institute

Lakeland, United States

Accellacare of McFarland

Ames, United States

LSU Health Sciences Center

Shreveport, United States

New England Cancer Specialists

Scarborough, United States

Maryland Oncology Hematology

Laurel, United States

Cancer Partners of Nebraska

Lincoln, United States

Nebraska Cancer Specialists

Omaha, United States

Astera Cancer Care (Formerly Regional Cancer Care Associates)

East Brunswick, United States

Medical Oncology Hematology Associates

Newark, United States

Hematology Oncology Associates of Central New York

Camillus, United States

Sarah Cannon Research Institute (Nashville)

Nashville, United States

Texas Oncology DFW

Dallas, United States

The University of Texas Southwestern Medical Center

Dallas, United States

Texas Oncology Gulf Coast

Houston, United States

Virginia Cancer Specialists

Fairfax, United States

Virginia Oncology Associates

Norfolk, United States

Shenandoah Oncology

Winchester, United States

Northwest Medical Specialties

Puyallup, United States

Northwest Cancer Specialists

Vancouver, United States

University of Wisconsin

Madison, United States

Ospedale San Raffaele

Milan, Italy

Hospital Clínico San Cecilio

Granada, Spain

Álvaro Cunqueiro Hospital

Vigo, Spain

Hospital Universitario Vall d'Hebron

Barcelona, Spain

Hospital Universitario Clinico San Cecilio,

Granada, Spain

Hosp Beata María Ana de Jesús

Madrid, Spain

Trial contact

Clinical Trial Disclosure & Transparency

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.