Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer with Disease Progression on or After Immunotherapy
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjenci z potwierdzonym histopatologicznie zaawansowanym rakiem pęcherza moczowego.
- •Pacjenci, którzy kwalifikują się do leczenia chemioterapią.
- •Pacjenci, którzy wcześniej otrzymywali leki z grupy anty-PD-(L)1 i u których choroba postępowała.
- •Pacjenci z przynajmniej jedną widoczną zmianą nowotworową, którą można zmierzyć.
- •Pacjenci, których ogólny stan zdrowia pozwala na aktywne działania (skala 0-1 ECOG).
✗ Disqualifies
- •Pacjenci, którzy otrzymywali chemioterapię w ciągu ostatnich 12 miesięcy.
- •Pacjenci, którzy otrzymali więcej niż dwa wcześniejsze różne schematy leczenia.
- •Pacjenci z aktywnymi, nieleczonymi przerzutami do mózgu.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 7, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (163)
Local Institution - 0167
Gilbert, United States
Local Institution - 0162
Fullerton, United States
Palo Alto Center-Palo Alto Medical Foundation Research Institute
Palo Alto, United States
Sutter Health - Sutter Institute for Medical Research
Sacramento, United States
University of California Davis (UC Davis) Comprehensive Cancer Center
Sacramento, United States
Pacific Hematology Oncology Associates
San Francisco, United States
Sutter Santa Rosa
Santa Rosa, United States
Rocky Mountain Cancer Centers, LLP
Denver, United States
Local Institution - 0245
Dillon, United States
Shaw Cancer Center
Edwards, United States
Sibley Memorial Hospital
Washington D.C., United States
Local Institution - 0247
Miami, United States
University of Kentucky Chandler Medical Center
Lexington, United States
Johns Hopkins Hospital
Baltimore, United States
Local Institution - 0195
Boston, United States
Karmanos Cancer Institute
Detroit, United States
Local Institution - 0248
Buffalo, United States
Icahn School of Medicine at Mount Sinai
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Fairview Hospital
Cleveland, United States
Cleveland Clinic
Cleveland, United States
The James Outpatient Care West Campus
Columbus, United States
Cleveland Clinic - Hillcrest Hospital
Mayfield Heights, United States
Local Institution - 0141
Portland, United States
SCRI Oncology Partners
Nashville, United States
Local Institution - 0084
Nashville, United States
Texas Oncology - West Texas
Abilene, United States
Local Institution - 0187
Austin, United States
Intermountain Medical Center
Murray, United States
St George Regional Hospital Cancer Center
St. George, United States
University of Virginia Health System
Charlottesville, United States
Local Institution - 0188
Norfolk, United States
Local Institution - 0200
Seattle, United States
Fred Hutchinson Cancer Center
Seattle, United States
Local Institution - 0259
Seattle, United States
Instituto Alexander Fleming
Caba, Argentina
Hospital Británico de Buenos Aires
CABA, Argentina
Asociación de Beneficencia Hospital Sirio Libanés
Ciudad Autonoma de Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
ABB, Argentina
IONC Instituto Oncologico de Cordoba - Fundacion Richardet Longo
Córdoba, Argentina
Fundacion Centro Oncologico de Integración Regional
Mendoza, Argentina
Macquarie University
Macquarie University, Australia
GenesisCare North Shore
St Leonards, Australia
Austin Health
Heidelberg, Australia
Medizinische Universität Wien
Vienna, Austria
Klinik Ottakring
Vienna, Austria
Medizinische Universitaet Innsbruck
Innsbruck, Austria
ZAS Augustinus
Wilrijk, Belgium
AZ Maria Middelares
Ghent, Belgium
UZ Gent
Ghent, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium
Local Institution - 0129
Salvador, Brazil
Local Institution - 0121
Porto Alegre, Brazil
Local Institution - 0130
Rio de Janeiro, Brazil
Local Institution - 0124
São Paulo, Brazil
Local Institution - 0020
Edmonton, Canada
The Ottawa Hospital Cancer Centre
Ottawa, Canada
Princess Margaret Cancer Centre
Toronto, Canada
McGill University Health Centre
Montreal, Canada
Local Institution - 0050
Beijing, China
Local Institution - 0224
Beijing, China
Local Institution - 0048
Fuzhou, China
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, China
Local Institution - 0056
Xiamen, China
Sun Yat-sen University Cancer Center
Guangzhou, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Zhujiang Hospital
Guangzhou, China
Local Institution - 0064
Zhengzhou, China
Local Institution - 0059
Changsha, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, China
Local Institution - 0046
Nanjing, China
Local Institution - 0114
Nantong, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
Shandong Cancer Hospital
Jinan, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Yantai Yuhuangding Hospital
Yantai, China
Local Institution - 0042
Shanghai, China
Sichuan Cancer hospital
Chengdu, China
West China Hospital, Sichuan University
Chengdu, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Local Institution - 0227
Tianjin, China
Local Institution - 0157
Hangzhou, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China
Local Institution - 0115
Brno, Czechia
Local Institution - 0146
Hradec Králové, Czechia
Local Institution - 0041
Prague, Czechia
Centre Antoine-Lacassagne
Nice, France
CHU Strasbourg-Hautepierre
Strasbourg, France
CHU de Bordeaux Hop St ANDRE
Bordeaux, France
Centre Leon Berard
Lyon Cedex08, France
CHRU de Brest
Brest, France
Hôpital Foch
Suresnes, France
Institut de Cancérologie de l'Ouest
Saint-Herblain, France
Local Institution - 0005
Marseille, France
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne
Clermont-Ferrand, France
Gustave Roussy
Villejuif, France
Hôpital Européen Georges Pompidou
Paris, France
Groupe hospitalier Paris saint Joseph
Paris, France
NCT
Heidelberg, Germany
Studienpraxis Urologie
Nürtingen, Germany
TUM Klinikum
Munich, Germany
Klinikum Nürnberg Nord
Nuremberg, Germany
Caritas-Krankenhaus St. Josef
Regensburg, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, Germany
Universitätsklinikum Jena
Jena, Germany
Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin
Berlin, Germany
Universitaetsklinikum Duesseldorf
Düsseldorf, Germany
Krankenhaus Nordwest GmbH
Frankfurt, Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, Germany
Marienhospital Herne
Herne, Germany
Universitaetsklinikum Ulm
Ulm, Germany
Local Institution - 0238
Cork, Ireland
Tallaght University Hospital
Dublin, Ireland
Rabin Medical Center
Petah Tikva, Israel
Yitzhak Shamir Medical Center
Ẕerifin, Israel
Hadassah Medical Center
Jerusalem, Israel
Rambam Health Care Campus
Haifa, Israel
A.O.U.C. Policlinico di Bari
Bari, Italy
IRCCS AOM Azienda Ospedaliera Metropolitana
Genoa, Italy
Istituto Nazionale Tumori Regina Elena
Rome, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
Istituto Oncologico Veneto IRCCS
Castelfranco Veneto, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
Ospedale San Raffaele
Milan, Italy
Azienda Ospedaliera Universitaria Federico II
Naples, Italy
Azienda Ospedaliero Universitaria di Parma
Parma, Italy
Local Institution - 0183
Kawasaki, Japan
Local Institution - 0171
Bunkyo-ku, Japan
Local Institution - 0169
Koto-ku, Japan
Local Institution - 0179
Toyoma, Japan
Local Institution - 0036
Breda, Netherlands
Local Institution - 0033
Amsterdam, Netherlands
Local Institution - 0031
Leeuwarden, Netherlands
Akershus Universitetssykehus
Lørenskog, Norway
Sykehuset i Vestfold
Tønsberg, Norway
Sykehuset Østfold Kalnes
Sarpsborg, Norway
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
Institutul Regional de Oncologie
Iași, Romania
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Fundación Instituto Valenciano de Oncología
Valencia, Spain
Hospital Infanta Cristina
Badajoz, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Clinico San Carlos
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Karolinska Universitetssjukhuset Solna
Solna, Sweden
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden
Local Institution - 0241
Malmö, Sweden
Cantonal Hospital St.Gallen
Sankt Gallen, Switzerland
Ospedale Regionale Bellinzona e Valli
Bellinzona, Switzerland
Kantonsspital Graubünden
Chur, Switzerland
UniversitätsSpital Zürich
Zurich, Switzerland
Local Institution - 0243
Glasgow, United Kingdom
St Bartholomew's Hospital
London, United Kingdom
Royal Marsden Hospital (Sutton)
London, United Kingdom
Local Institution - 0230
Sheffield, United Kingdom
Trial contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
First line of the email MUST contain NCT # and Site #.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
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