BCD-236 in Combination With Chemotherapy in Patients With Relapsed and/or Metastatic Triple Negative Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
To study the efficacy, safety, pharmacokinetics and immunogenicity of BCD-236 in combination with chemotherapeutic agents (CHT) in 2nd and subsequent lines of therapy of subjects with relapsed and/or metastatic triple negative breast cancer (TNBC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Podpisana świadoma zgoda i zdolność do uczestniczenia w badaniu
- •Wiek od 18 do 74 lat
- •Potwierdzony rozpoznaniem raka piersi trójujemnego (TNBC) - brak receptorów na estrogen, progesteron i białko HER2
- •Nowotwór postępujący lub powracający mimo leczenia systemowego
- •Wcześniejsze leczenie systemowe (co najmniej jedno) lub nawrót choroby w ciągu 6 miesięcy po chemioterapii poadjuwantowej
- •Potwierdzona obecność białka AXL w komórkach nowotworu
- •Dostępne próbki guza do badań (świeże i archiwalne)
- •Co najmniej jeden mierzalny guz według kryteriów RECIST 1.1
✗ Disqualifies
- •Wskazania do zabiegu operacyjnego lub radioterapii kuracyjnej
- •Czynne przerzuty do mózgu lub zapalenie opon mózgowych; przerzuty mózgowe mogą być dopuszczone, jeśli były leczone i były stabilne przez co najmniej 4 tygodnie
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 74 Years
- Last updated (source)
- August 7, 2025
- Sex
- Female only
Therapies / drugs in trial
Locations (47)
Health Institution "Brest Regional Oncology Center"
Brest, Belarus
"Gomel Regional Clinical Oncology Dispensary"
Homyel, Belarus
Minsk City Oncology Center
Minsk, Belarus
State Budgetary Institution of Healthcare of the Arkhangelsk Region "Arkhangelsk Clinical Oncology Dispensary"
Arkhangelsk, Russia
Regional State Budgetary Healthcare Institution "Altai Regional Oncology Dispensary"
Barnaul, Russia
SBHI "Chelyabinsk regional clinical center Oncology and nuclear medicines"
Chelyabinsk, Russia
Budgetary healthcare institution of the Udmurt Republic "Republican clinical oncology dispensary named after Sergei Grigorievich Primushko of the Ministry of Health of the Udmurt Republic
Izhevsk, Russia
SBHI of the Kaluga Region "Kaluga Regional Clinical Oncology Center"
Kaluga, Russia
State Autonomous Institution of Health "Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan named after prof. M.Z.Sigal"
Kazan', Russia
SBHI "Clinical oncological Dispensary № 1" of the Ministry of Health of the Krasnodar Territory
Krasnodar, Russia
Branch of company "Hadassah Medical LCC"
Moscow, Russia
Federal State Budgetary Scientific Institution "Russian Scientific Center of Surgery named after Academician B.V. Petrovsky"
Moscow, Russia
FSAEI of Higher Education "First Moscow State Medical University named after I.M. Sechenov" of the Ministry of Health of the Russian Federation
Moscow, Russia
FSAEI of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Moscow, Russia
FSAI "National Medical Research Center for Therapeutic and Rehabilitation Center" of the Ministry of Health of the Russian Federation
Moscow, Russia
FSBI "Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency"
Moscow, Russia
FSBI "National Medical Research Center of Oncology named after N. N. Blokhin" of the Ministry of Health of the Russian Federation
Moscow, Russia
Joint Stock Company "Medsi Group of Companies"
Moscow, Russia
JSC "Modern medical technologies"
Moscow, Russia
Limited Liability Company "Moscow Center for Rehabilitation Treatment"
Moscow, Russia
SBHI of the City of Moscow "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Moscow City Health Department"
Moscow, Russia
State Budgetary Institution of Healthcare of the City of Moscow "City Clinical Hospital named after S.S. Yudin of the Moscow City Health Department
Moscow, Russia
State Budgetary Institution of Healthcare of the City of Moscow "Moscow City Oncology Hospital No. 62 of the Moscow City Healthcare Department"
Moscow, Russia
SAHI of the Nizhny Novgorod region "Research Institute of Clinical Oncology "Nizhny Novgorod Regional Clinical Oncological Dispensary"
Nizhny Novgorod, Russia
FBHI of the Novosibirsk Region "Novosibirsk Regional Clinical Oncological Dispensary"
Novosibirsk, Russia
FSBI "National Medical Research Center for Radiology" of the Ministry of Health of the Russian Federation
Obninsk, Russia
FSBI "National Medical Research Center of Radiology" of the Ministry of Health of the Russian Federation Medical Radiological Research Center named after A.F. Tsyb
Obninsk, Russia
Budget Healthcare Institution of the Omsk region "Clinical Oncological Dispensary"
Omsk, Russia
FSBI "National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation
Rostov-on-Don, Russia
State budgetary institution of the Ryazan region "Regional clinical oncology dispensary"
Ryazan, Russia
FSBEI of Higher Education "North-Western State Medical University named after I. I. Mechnikov" of the Ministry of Health of the Russian Federation
Saint Petersburg, Russia
FSBI "National medical research center of Oncology named after N.N. Petrov" Of Ministry of Health of the Russian Federation, Department of Breast Cancer Surgery
Saint Petersburg, Russia
FSBI "National medical research center of Oncology named after N.N. Petrov" Of Ministry of Health of the Russian Federation, Research Division of Innovative Techniques in Medical Oncology and Rehabilitation Medicine
Saint Petersburg, Russia
LLC "NRC Eco-Safety"
Saint Petersburg, Russia
LLC "VitaMed"
Saint Petersburg, Russia
Private healthcare institution "Clinical hospital "RZD-Medicine" of the city of St. Petersburg"
Saint Petersburg, Russia
Private medical institution "Euromedservice"
Saint Petersburg, Russia
SBHI "St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological) named after N.P. Napalkov"
Saint Petersburg, Russia
SBHI of St. Petersburg "City Clinical Oncology Dispensary"
Saint Petersburg, Russia
State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital
Saint Petersburg, Russia
Federal State Budgetary Educational Institution of Higher Education "National Research Mordovian State University named after N.P. Ogarev"
Saransk, Russia
SBHI Arkhangelsk Region "Severodvinsk City Clinical Hospital No. 2 for Emergency Medicine"
Severodvinsk, Russia
State Budgetary Healthcare Institution "Tambov Regional Oncology Clinical Dispensary"
Tambov, Russia
SAHI Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Bashkortostan
Ufa, Russia
SBHI "Volgograd Regional Clinical Oncological Dispensary"
Volgograd, Russia
SBHI of the Yaroslavl region "Regional Clinical Oncological Hospital"
Yaroslavl, Russia
SAHI of the Sverdlovsk region "Sverdlovsk Regional Oncological Center"
Yekaterinburg, Russia
Trial contact
Evgenia А Mikhailova
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.