A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a multi-site, open-label, dose-finding study, consisting of Parts 1, 2a, and 2b to investigate the combination of BNT326 with pumitamig (also known as BNT327 or PM8002) in participants with relapsed, progressive as well as treatment-naïve, advanced/metastatic non-small cell lung cancer (NSCLC). This study will enroll adult participants with histologically or cytologically confirmed NSCLC that is advanced (i.e., either metastatic or recurrent tumors with no known curative treatment available). The main goals of this study are: 1. To find the best dose levels (DLs) for the combination of BNT326 and pumitamig. 2. To look at how well participants with advanced NSCLC tolerate the combination therapy (for example, which side effects participants experience and how severe they are). 3. To look at how well the combination therapy works to shrink the tumor in participants with advanced NSCLC.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Zaawansowany rak płuca (rozprzestrzeniony na inne narządy lub powracający lokalnie)
- •Guz widoczny na badaniach obrazowych
- •Dobra sprawność fizyczna oceniana przez lekarza
- •Prawidłowe funkcje narządów wewnętrznych i szpiku kostnego
- •Wcześniejsze leczenie (1-3 linie terapii w przypadku choroby zaawansowanej)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (85)
UCLA Hematology Oncology - Main Site
Los Angeles, United States
Stanford Cancer Institute
Stanford, United States
Yale University
New Haven, United States
Georgetown University - Lombardi Comprehensive Cancer Center
Washington D.C., United States
Moffit Cancer Center
Tampa, United States
Dana-Farber Cancer Institute
Boston, United States
Henry Ford Health System
Detroit, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center
Cleveland, United States
University of Texas M. D. Anderson Cancer Center
Houston, United States
NEXT Virginia
Fairfax, United States
Cancer Research SA
Adelaide, Australia
St George Private Hospital
Kogarah, Australia
Royal North Shore Hospital
Saint Leonards, Australia
Mater
South Brisbane, Australia
John Flynn Private Hospital
Tugun, Australia
Westmead Hospital
Westmead, Australia
Affiliated Hospital of Hebei University
Baoding, China
Beijing GoBroad Hospital
Beijing, China
The First Hospital of Jilin University
Changchun, China
West China Hospital, Sichuan University
Chengdu, China
Chongqing University Cancer Hospital
Chongqing, China
Fujian Provincial Cancer Hospital
Fuzhou, China
The First Affiliated Hospital School of Clinical Medicine of Guangdong Pharmaceutical University
Guangzhou, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Anhui Chest Hospital
Hefei, China
The First Affiliated Hospital of Anhui Medical University
Hefei, China
Anhui Provincial Cancer Hospital
Hefei, China
The Second Hospital of Anhui Medical University
Hefei, China
Jinan Central Hospital
Jinan, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Shanghai East Hospital
Shanghai, China
Shanghai GoBroad Cancer Hospital
Shanghai, China
The First Affiliated Hospital of Soochow University
Suzhou, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Hubei Cancer Hospital
Wuhan, China
Xiangyang Central Hospital
Xiangyang, China
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, China
Xuzhou Central Hospital
Xuzhou, China
Northern Jiangsu People's Hospital
Yangzhou, China
Universitätsklinikum Carl Gustav Carus TU Dresden
Dresden, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
Thoraxklinik Heidelberg gGmbH
Heidelberg, Germany
Azienda Ospedaliero - Universitaria Nazionale Santi Antonio e Biagio e Cesare Arrigo
Alessandria, Italy
Azienda Ospedaliero Universitaria Policlinico "Gaspare Rodolico - San Marco" (Presidio G. Rodolico)
Catania, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, Italy
IEO Istituto Europeo di Oncologia
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
Institute of Oncology, ARENSIA Exploratory Medicine
Chisinau, Moldova
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Pratia MCM Krakow
Krakow, Poland
Centrum Medyczne Pratia Poznan
Poznan, Poland
Med-Polonia Sp. z o.o.
Poznan, Poland
Provita Prolife
Tomaszów Mazowiecki, Poland
Hospital Universitari Dexeus
Barcelona, Spain
Hospital Universitari Vall d'Hebron - VHIO
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario HM Madrid Sanchinarro
Madrid, Spain
Pratia ES Hospital Universitario de Torrejon
Madrid, Spain
Clinica Universidad de Navarra
Madrid, Spain
Hospital Quironsalud Malaga
Málaga, Spain
Clinica Universidad de Navarra
Pamplona, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitari i Politecnic La Fe
Valencia, Spain
Medical Park Seyhan Hospital
Adana, Turkey (Türkiye)
Adana City Hospital
Adana, Turkey (Türkiye)
Baskent University Adana Application and Research Center
Adana, Turkey (Türkiye)
Hacettepe University Medical Faculty
Ankara, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Oncology Research and Training Hospital, Clinical Research Center
Ankara, Turkey (Türkiye)
Gazi University Medical Faculty
Ankara, Turkey (Türkiye)
Ankara Memorial Hospital
Ankara, Turkey (Türkiye)
Memorial Antalya Hastanesi
Antalya, Turkey (Türkiye)
Yeditepe University Medical School Hospital
Istanbul, Turkey (Türkiye)
Koc University Hospital
Istanbul, Turkey (Türkiye)
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul, Turkey (Türkiye)
Mersin City Education and Research Hospital
Mersin, Turkey (Türkiye)
Sakarya Training and Research Hospital
Sakarya, Turkey (Türkiye)
Royal Free Hospital
London, United Kingdom
Royal Marsden Hospital
London, United Kingdom
Northern Centre for Cancer Care
Newcastle upon Tyne, United Kingdom
Royal Marsden Hospital-Sutton
Sutton, United Kingdom
Trial contact
BioNTech clinical trials patient information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/6/2026.
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