This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is a first-in-human (FIH), Phase 1, multicenter, open-label study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and evaluate the preliminary anti-tumor activity of LTZ-301 administered as a single agent in adult subjects with relapsed or refractory B-cell non-Hodgkin lymphoma
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Wcześniejsze leczenie co najmniej 2 schematami chemioterapii bez ostatecznego efektu lub z nawrotem choroby
- •Widoczny guz o wymiarach co najmniej 1,5 cm
- •Dobry ogólny stan zdrowia (status performance 0 lub 1)
- •Prawidłowa funkcja szpiku kostnego, serca, płuc, nerek i wątroby
✗ Disqualifies
- •Białaczka limfocytarna lub transformacja Richtera
- •Przeszczep organu lub przeszczep komórek macierzystych
- •Transplantacja autologiczna komórek macierzystych w ciągu ostatnich 100 dni
- •Poprzednia terapia CAR-T w ciągu ostatnich 60 dni
- •Chłoniak ośrodkowego układu nerwowego
- •Zakażenie HIV
- •Aktywna choroba autoimmunologiczna
- •Historia zakrzepicy żyły głębokich w ostatnich 3 miesiącach
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (6)
City of Hope
Duarte, United States
Washington University School of Medicine
St Louis, United States
Roswell Park Cancer Institute
Buffalo, United States
Memorial Sloan Kettering Cancer Center - Bergen
New York, United States
Tennessee Oncology
Nashville, United States
Fred Hutchinson Cancer Center
Seattle, United States
Trial contact
Sherry Unabia
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/26/2026.
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