Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is being done to answer the main question of: Do patients with colorectal cancer that cannot be removed by surgery, that is treated with two new immunotherapy drugs, botensilimab and balstilimab, live longer? Other important questions include: Is their quality of life better? Do their tumours slow in growth or possibly shrink in size? Are there markers in their tumour or blood that can predict whether they achieve any of these benefits? In addition, the study is done to confirm the safety of these immunotherapy drugs and to determine how long it takes for the body to metabolize them.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak jelita grubego potwierdzony badaniem.
- •Choroba jest nieoperacyjna i standardowe leczenie zawiodło.
- •Pacjent jest w dobrym ogólnym stanie zdrowia (typowa ocena 0 lub 1).
- •Istnieją widoczne lub ocenialne zmiany chorobowe.
- •Przewidywana długość życia wynosi co najmniej 12 tygodni.
- •Pacjent ma co najmniej 18 lat.
- •Zgoda na pobranie fragmentu guza do dalszych badań.
- •Organy i szpik kostny działają prawidłowo.
✗ Disqualifies
- •Wcześniejsze lub obecne inne choroby nowotworowe, które mogą wpłynąć na wyniki badania.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (55)
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Canada
BCCA - Prince George
Prince George, Canada
BCCA - Vancouver
Vancouver, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Canada
Kingston Health Sciences Centre
Kingston, Canada
Waterloo Regional Health Network (WRHN)
Kitchener, Canada
London Health Sciences Centre Research Inc.
London, Canada
Lakeridge Health Oshawa
Oshawa, Canada
Ottawa Hospital Research Institute
Ottawa, Canada
Niagara Health System
St. Catharines, Canada
North York General Hospital
Toronto, Canada
St. Michael's Hospital
Toronto, Canada
Sinai Health System
Toronto, Canada
University Health Network
Toronto, Canada
Centre Integre de Sante et de Services Sociaux
Greenfield Park, Canada
CIUSSS de l'Est-de-I'lle-de-Montreal
Montreal, Canada
CHUM-Centre Hospitalier de l'Universite de Montreal
Montreal, Canada
The Jewish General Hospital
Montreal, Canada
Hotel-Dieu de Quebec
Québec, Canada
CIUSSS de l'Estrie - Centre hospitalier
Sherbrooke, Canada
Allan Blair Cancer Centre
Regina, Canada
Saskatoon Cancer Centre
Saskatoon, Canada
ICO Angers
Angers, France
Institut du Cancer Avignon Sainte Catherine
Avignon, France
CHU de Besançon
Besançon, France
Institut Bergonié
Bordeaux, France
Centre François Baclesse
Caen, France
Centre Jean Perrin
Clermont-Ferrand, France
CHU Estaing de Clermont-Ferrand
Clermont-Ferrand, France
Centre Georges François Leclerc
Dijon, France
GH Mutualiste de Grenoble
Grenoble, France
CHD de Vendée
La Roche-sur-Yon, France
Hôpital Franco-Britannique - fondation Cognacq-Jay
Levallois-Perret, France
CHU de Lille
Lille, France
CHU Dupuytren
Limoges, France
Centre Léon Bérard
Lyon, France
Hôpital Privé Jean Mermoz
Lyon, France
Institut Paoli Calmettes
Marseille, France
Institut Régional du Cancer de Montpellier
Montpellier, France
CHU de Nantes
Nantes, France
Hôpital Privé du Confluent
Nantes, France
GH Diaconesses Croix Saint Simon
Paris, France
Hôpital Européen Georges Pompidou
Paris, France
CHU de Perpignan
Perpignan, France
CHU de Bordeaux - Hôpital Haut Leveque
Pessac, France
CHU de Poitiers
Poitiers, France
CHU de Reims
Reims, France
Centre Eugène Marquis
Rennes, France
Centre Hospitalier Privé Saint Grégoire
Saint-Grégoire, France
ICO Saint Herblain
Saint-Herblain, France
Centre Paul Strauss
Strasbourg, France
Hôpital Foch
Suresnes, France
CHU de Toulouse
Toulouse, France
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France
Gustave Roussy
Villejuif, France
Trial contact
Chris O'Callaghan
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.