Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic malignancies with KMT2Ar, NPM1m, or other genotypes associated with homeobox (HOX) overexpression.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie zaawansowanej białaczki ostrej lub zespołu mielodysplastycznego z określonymi zmianami genetycznymi
- •Choroba, która wróciła po leczeniu lub nie odpowiada na standardowe terapie
- •Wcześniejsze leczenie co najmniej dwoma cyklami chemioterapii lub lekami do leczenia zespołów mielodysplastycznych
- •Liczba białych krwinek poniżej 25 000 na mikroliter
- •Dobry stan ogólny pacjenta (skala ECOG ≤ 2)
- •Oczekiwana długość życia co najmniej 8 tygodni
- •Prawidłowa funkcja narządów wewnętrznych
- •Stosowanie antykoncepcji zgodne z lokalnymi przepisami
Simplified criteria — AI translation
Trial details
- Minimum age
- 16 Years
- Last updated (source)
- July 20, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (30)
Research Site
Decatur, United States
Research Site
New York, United States
Research Site
Chapel Hill, United States
Research Site
Durham, United States
Research Site
Portland, United States
Research Site
Houston, United States
Research Site
Fitzroy, Australia
Research Site
Perth, Australia
Research Site
Toronto, Canada
Research Site
Montreal, Canada
Research Site
Copenhagen, Denmark
Research Site
Dresden, Germany
Research Site
Frankfurt A. Main, Germany
Research Site
Halle, Germany
Research Site
Heidelberg, Germany
Research Site
München, Germany
Research Site
Ulm, Germany
Research Site
Bologna, Italy
Research Site
Ravenna, Italy
Research Site
Bunkyō City, Japan
Research Site
Kashiwa, Japan
Research Site
Okayama, Japan
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Edinburgh, United Kingdom
Research Site
London, United Kingdom
Research Site
London, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Newcastle, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
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