Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares the effect of immunotherapy (IO) with stereotactic body radiation therapy (SBRT) to IO alone in treating patients with liver cancer (hepatocellular cancer) that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). The usual approach is treatment with IO-based drug combinations, such as atezolizumab and bevacizumab, durvalumab and tremelimumab, or ipilimumab and nivolumab. IO with monoclonal antibodies, such as durvalumab, tremelimumab, atezolizumab, nivolumab and ipilimumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor cells. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Giving IO with SBRT may be more effective than IO alone in helping patients with advanced hepatocellular cancer live longer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak wątroby (najlepiej biopsją, ale dopuszczalne są badania obrazowe)
- •Nowotwór z naczyniami krwionośnymi w wątrobie
- •Maksymalnie 5 guzów w wątrobie, łącznie mniejszych niż 20 cm
- •Przerzuty poza wątrobę są dozwolone
- •Funkcja wątroby klasy A lub B7
- •Wiek co najmniej 18 lat
- •Stan ogólny pacjenta pozwalający na leczenie (ECOG 0-2)
- •Wystarczająca liczba komórek krwi do leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (139)
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, United States
Palo Alto Medical Foundation-Fremont
Fremont, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
Palo Alto Medical Foundation-Camino Division
Mountain View, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Palo Alto Medical Foundation Health Care
Palo Alto, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, United States
Sutter Roseville Medical Center
Roseville, United States
Sutter Medical Center Sacramento
Sacramento, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
California Pacific Medical Center-Pacific Campus
San Francisco, United States
Sutter Pacific Medical Foundation
Santa Rosa, United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, United States
UCHealth Memorial Hospital Central
Colorado Springs, United States
Memorial Hospital North
Colorado Springs, United States
Poudre Valley Hospital
Fort Collins, United States
Cancer Care and Hematology-Fort Collins
Fort Collins, United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction, United States
UCHealth Greeley Hospital
Greeley, United States
Medical Center of the Rockies
Loveland, United States
Smilow Cancer Hospital-Derby Care Center
Derby, United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, United States
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, United States
Smilow Cancer Hospital Care Center - Guilford
Guilford, United States
Smilow Cancer Hospital-Hamden Care Center
Hamden, United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, United States
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, United States
Yale University
New Haven, United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, United States
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
Christiana Care Health System-Christiana Hospital
Newark, United States
Christiana Care Health System-Wilmington Hospital
Wilmington, United States
Grady Health System
Atlanta, United States
Emory Proton Therapy Center
Atlanta, United States
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
University of Illinois
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Carle at The Riverfront
Danville, United States
Carle Physician Group-Effingham
Effingham, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, United States
University of Chicago Medicine-Orland Park
Orland Park, United States
Memorial Hospital East
Shiloh, United States
Carle Cancer Center
Urbana, United States
UChicago Medicine Northwest Indiana
Crown Point, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Mercy Cancer Center-West Lakes
Clive, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Greater Regional Medical Center
Creston, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
Mercy Medical Center-West Lakes
West Des Moines, United States
The Iowa Clinic PC
West Des Moines, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
Massachusetts General Hospital Cancer Center
Boston, United States
Henry Ford Cancer Institute-Downriver
Brownstown, United States
Henry Ford Medical Center-Fairlane
Dearborn, United States
Henry Ford Hospital
Detroit, United States
Allegiance Health
Jackson, United States
Henry Ford Medical Center-Columbus
Novi, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, United States
Henry Ford Wyandotte Hospital
Wyandotte, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Cancer Center
Duluth, United States
Essentia Health Saint Mary's Medical Center
Duluth, United States
Miller-Dwan Hospital
Duluth, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Essentia Health Sandstone
Sandstone, United States
Essentia Health Virginia Clinic
Virginia, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Nebraska Medicine-Bellevue
Bellevue, United States
Nebraska Medicine-Village Pointe
Omaha, United States
University of Nebraska Medical Center
Omaha, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
University of New Mexico Cancer Center
Albuquerque, United States
Northwell Health/Center for Advanced Medicine
Lake Success, United States
Mount Sinai Hospital
New York, United States
Montefiore Medical Center-Einstein Campus
The Bronx, United States
Montefiore Medical Center - Moses Campus
The Bronx, United States
Duke University Medical Center
Durham, United States
Duke Cancer Center Raleigh
Raleigh, United States
UH Seidman Cancer Center at UH Avon Health Center
Avon, United States
UHHS-Chagrin Highlands Medical Center
Beachwood, United States
Case Western Reserve University
Cleveland, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, United States
Clackamas Radiation Oncology Center
Clackamas, United States
Providence Newberg Medical Center
Newberg, United States
Providence Willamette Falls Medical Center
Oregon City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Christiana Care Health System-Concord Health Center
Chadds Ford, United States
Geisinger Medical Center
Danville, United States
Geisinger Cancer Center Dickson City
Dickson City, United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, United States
Inova Alexandria Hospital
Alexandria, United States
Inova Schar Cancer Institute
Fairfax, United States
Inova Fair Oaks Hospital
Fairfax, United States
Inova Fairfax Hospital
Falls Church, United States
Inova Loudoun Hospital
Leesburg, United States
Duluth Clinic Ashland
Ashland, United States
Northwest Wisconsin Cancer Center
Ashland, United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, United States
Essentia Health-Hayward Clinic
Hayward, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
ProHealth D N Greenwald Center
Mukwonago, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Drexel Town Square Health Center
Oak Creek, United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, United States
Marshfield Medical Center-Rice Lake
Rice Lake, United States
Essentia Health-Spooner Clinic
Spooner, United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, United States
Essentia Health Saint Mary's Hospital - Superior
Superior, United States
UW Cancer Center at ProHealth Care
Waukesha, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Marshfield Medical Center - Weston
Weston, United States
University Health Network-Princess Margaret Hospital
Toronto, Canada
Trial contact
Site Public Contact
Jorge A. Garcia-Young
PRINCIPAL_INVESTIGATOR
Site Public Contact
Caressa Hui
PRINCIPAL_INVESTIGATOR
Site Public Contact
Edward J. Kim
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Shahzad Siddique
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joshua H. Petit
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Lucas Gilbride
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Kevin L. Du
PRINCIPAL_INVESTIGATOR
Site Public Contact
Gregory A. Masters
PRINCIPAL_INVESTIGATOR
Site Public Contact
Soumon Rudra
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Mark C. Korpics
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joseph Franses
PRINCIPAL_INVESTIGATOR
Site Public Contact
Prem Sobti
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Benjamin R. Tan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Mark E. Bernard
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jennifer Y. Wo
PRINCIPAL_INVESTIGATOR
Site Public Contact
Parag J. Parikh
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Bret E. Friday
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Mridula Krishnan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Nirav S. Kapadia
PRINCIPAL_INVESTIGATOR
Site Public Contact
Benny J. Liem
PRINCIPAL_INVESTIGATOR
Site Public Contact
Baho U. Sidiqi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael H. Buckstein
PRINCIPAL_INVESTIGATOR
Site Public Contact
Byung-Han Rhieu
PRINCIPAL_INVESTIGATOR
Site Public Contact
Manisha Palta
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Lauren E. Henke
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Eric D. Miller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Dan S. Zuckerman
PRINCIPAL_INVESTIGATOR
Site Public Contact
Austin J. Iovoli
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Grace Lee
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Anderson A. Bauer
PRINCIPAL_INVESTIGATOR
Site Public Contact
William A. Hall
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Timothy R. Wassenaar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Aruz Mesci
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/18/2026.
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