ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to investigate whether adjuvant chemotherapy can prevent disease recurrence in patients with high-risk rectal cancer who have detectable ctDNA after surgery. The main research question the REACT study aims to answer is: \- Does adjuvant chemotherapy improve disease-free survival in patients with high-risk rectal cancer with detectable ctDNA after surgery? Interventions: \- Patients with detectable ctDNA after surgery and randomised to the experimental group will be offered adjuvant chemotherapy (4 cycles CAPOX/6 cycles FOLFOX) within 12 weeks after surgery.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wykryto cząsteczki ctDNA we krwi po operacji.
- •Wiek 18 lat lub więcej.
- •Ogólny stan zdrowia dobry (niezależność od pomocy innych osób w codziennych czynnościach).
- •Pacjent świadomie zgadza się na udział w badaniu.
- •Rak odbytnicy potwierdzony badaniem histologicznym, wymagający leczenia.
- •Lekarz ocenia, że pacjent może otrzymać chemioterapię.
✗ Disqualifies
- •Rak odbytnicy z przerzutami do innych narządów.
- •Inny nowotwór w ciągu ostatnich 5 lat (z pewnymi wyjątkami).
- •Niewystarczające usunięcie guza pierwotnego podczas operacji.
- •Przeciwwskazania do stosowania leków w chemioterapii.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (25)
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
Ziekenhuisgroep Twente
Almelo, Netherlands
Meander Medisch Centrum
Amersfoort, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
Amphia
Breda, Netherlands
Reinier de Graaf Ziekenhuis
Delft, Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
Catharina Ziekenhuis
Eindhoven, Netherlands
Admiraal De Ruyter Ziekenhuis
Goes, Netherlands
Martini Ziekenhuis
Groningen, Netherlands
Dijklander Ziekenhuis
Hoorn, Netherlands
Frisius MC
Leeuwarden, Netherlands
Leids Universitair Medisch Centrum (LUMC)
Leiden, Netherlands
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Radboud Universitair Medisch Centrum
Nijmegen, Netherlands
Bravis Ziekenhuis
Roosendaal, Netherlands
Erasmus MC
Rotterdam, Netherlands
Franciscus
Rotterdam, Netherlands
Ikazia Ziekenhuis
Rotterdam, Netherlands
Maasstad Ziekenhuis
Rotterdam, Netherlands
Antonius Ziekenhuis Sneek
Sneek, Netherlands
ZorgSaam
Terneuzen, Netherlands
Haaglanden Medisch Centrum
The Hague, Netherlands
Elisabeth-Tweesteden Ziekenhuis
Tilburg, Netherlands
Bernhoven
Uden, Netherlands
Trial contact
Mirthe Ubink, MD
Cornelis Verhoef, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/3/2026.
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