RecruitingPhase III🇵🇱 PolandEN originalLung cancer

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation. The goal of this study is to learn if people who receive calderasib with SC pembrolizumab live longer without the cancer growing or spreading than in people who receive SC pembrolizumab with chemotherapy.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Rak płuca (NSCLC) innego typu niż płaskonabłonkowy, który nie kwalifikuje się do leczenia z intencją wyleczenia lub jest w zaawansowanym stadium (IV).
  • Osoby zakażone wirusem HIV, u których choroba jest dobrze kontrolowana przyjmowanymi lekami.

✗ Disqualifies

  • Rak płuca typu drobnokomórkowego.
  • Aktywne problemy jelitowe wymagające leków osłabiających odporność lub w przeszłości poważne choroby jelit (np. choroba Leśniowskiego-Crohna, wrzodziejące zapalenie jelita grubego).
  • Niekontrolowane choroby serca lub naczyń mózgowych.
  • Problemy z wchłanianiem w przewodzie pokarmowym.
  • Osoby zakażone wirusem HIV, które miały w przeszłości mięsaka Kaposiego lub wieloośrodkową chorobę Castlemana.
  • Przed rozpoczęciem badania przyjmowali już leki na zaawansowanego raka płuca.
  • Inny aktywny nowotwór, który postępuje lub był leczony w ciągu ostatnich 3 lat.
  • Aktywne przerzuty do mózgu lub zapalenie opon mózgowych spowodowane przez nowotwór.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 20, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (195)

Central Alabama Research ( Site 0108)

Birmingham, United States

University of Connecticut Health Center ( Site 0130)

Farmington, United States

Stamford Hospital ( Site 0126)

Stamford, United States

Mount Sinai Cancer Center ( Site 0137)

Miami Beach, United States

Indiana University Health Arnett Cancer Center ( Site 0116)

Lafayette, United States

New England Cancer Specialists ( Site 0139)

Westbrook, United States

New York Oncology Hematology, P.C. ( Site 0119)

Albany, United States

St. Charles Health System, Inc ( Site 0146)

Bend, United States

Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0111)

Lancaster, United States

Blue Ridge Cancer Care ( Site 0144)

Roanoke, United States

Instituto Alexander Fleming ( Site 0311)

Ciudad Autónoma de Buenos Aires, Argentina

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0300)

Mar del Plata, Argentina

Hospital Italiano de Cordoba ( Site 0308)

Córdoba, Argentina

CEMAIC ( Site 0309)

Córdoba, Argentina

Genesis Care- Campbelltown ( Site 2907)

Campbelltown, Australia

Northern Beaches Hospital ( Site 2905)

Frenchs Forest, Australia

The Prince Charles Hospital ( Site 2903)

Brisbane, Australia

Mater Hospital Brisbane ( Site 2906)

South Brisbane, Australia

Peninsula & South Eastern Haematology and Oncology Group ( Site 2908)

Frankston, Australia

Klinikum Klagenfurt am Wörthersee ( Site 1002)

Klagenfurt, Austria

Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 1005)

Graz, Austria

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1001)

Vienna, Austria

Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 3903)

Genk, Belgium

VITAZ ( Site 3902)

Sint-Niklaas, Belgium

CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0412)

Fortaleza, Brazil

Hospital Santa Rita de Cassia ( Site 0403)

Vitória, Brazil

Real Hospital Portugues ( Site 0418)

Recife, Brazil

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa ( Site 0400)

Porto Alegre, Brazil

CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0410)

Florianópolis, Brazil

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto USP ( Site 0419)

Ribeirão Preto, Brazil

Faculdade de Medicina do ABC ( Site 0411)

Santo André, Brazil

Hospital Alemao Oswaldo Cruz ( Site 0413)

São Paulo, Brazil

IBCC - Núcleo de Pesquisa e Ensino ( Site 0417)

São Paulo, Brazil

Cross Cancer Institute ( Site 0203)

Edmonton, Canada

Centro de Estudios Clínicos SAGA ( Site 0503)

Santiago, Chile

FALP ( Site 0500)

Santiago, Chile

Bradfordhill ( Site 0501)

Santiago, Chile

Anhui Provincial Cancer Hospital ( Site 2708)

Hefei, China

Beijing Cancer hospital-Thoracic Cancer Department A ( Site 2700)

Beijing, China

Beijing Peking Union Medical College Hospital ( Site 2702)

Beijing, China

The First Affiliated Hospital of Fujian Medical University ( Site 2701)

Fujian, China

Fujian Provincial Cancer Hospital ( Site 2706)

Fuzhou, China

The First Affiliated Hospital of Xiamen University ( Site 2717)

Fuzhou, China

The First Affiliated Hospital.Sun Yat-sen University ( Site 2714)

Guangzhou, China

AFFILIATED CANCER HOSPITAL AND INSTITUTE OF GUANGZHOU MEDICAL UNIVERSITY ( Site 2743)

Guangzhou, China

Zhujiang Hospital of Southern Medical University ( Site 2744)

Guangzhou, China

Affiliated Cancer Hospital of Guangxi Medical University ( Site 2704)

Nanning, China

JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 2745)

Jiamusi, China

Henan Cancer Hospital ( Site 2746)

Zhengzhou, China

Tongji Hospital Tongji Medical,Science & Technology ( Site 2722)

Wuhan, China

Hubei Cancer Hospital ( Site 2721)

Wuhan, China

Xiangya Hospital Central South University ( Site 2741)

Changsha, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 2715)

Nanjing, China

Jiangxi Cancer Hospital ( Site 2725)

Nanchang, China

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 2729)

Xi'an, China

LinYi Cancer Hospital ( Site 2737)

Linyi, China

Shanghai Pulmonary Hospital-Oncology Department ( Site 2723)

Shanghai, China

Shanxi Cancer Hospital ( Site 2728)

Taiyuan, China

Sichuan Cancer Hospital. ( Site 2739)

Chengdu, China

West China Hospital Sichuan University ( Site 2735)

Chengdu, China

Chongqing University Cancer Hospital ( Site 2736)

Chongqing, China

Yunnan Province Cancer Hospital ( Site 2734)

Kunming, China

The First Affiliated Hospital, Zhejiang University ( Site 2716)

Hangzhou, China

Sir Run Run Shaw Hospital ( Site 2731)

Hangzhou, China

Zhejiang Cancer Hospital ( Site 2727)

Hangzhou, China

Taizhou Hospital of Zhejiang Province-Respiratory ( Site 2724)

Taizhou, China

Instituto De Cancerologia S.A. ( Site 0608)

Medellín, Colombia

Hospital Universitario San Ignacio ( Site 0604)

Bogotá, Colombia

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0607)

Bogotá, Colombia

Hopital Europeen Marseille ( Site 1207)

Marseille, France

CHU Caen ( Site 1212)

Caen, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 1209)

Vandœuvre-lès-Nancy, France

Centre Hospitalier de Pau ( Site 1217)

Pau, France

Centre Hospitalier Metropole Savoie Site de Chambery ( Site 1208)

Chambéry, France

Clinique de l'Europe ( Site 1213)

Amiens, France

Groupe Hospitalier Paris Saint Joseph ( Site 1215)

Paris, France

Hôpital Européen Georges Pompidou ( Site 1214)

Paris, France

Agios Andreas Hospital Patras ( Site 1407)

Pátrai, Greece

Errikos Dunant Hospital Center ( Site 1408)

Athens, Greece

General Hospital of Athens "Laiko" ( Site 1402)

Athens, Greece

Metropolitan General Hospital ( Site 1400)

Athens, Greece

Papageorgiou General Hospital of Thessaloniki ( Site 1403)

Thessaloniki, Greece

MEDI-K ( Site 3803)

Guatemala City, Guatemala

Centro Integral De Oncologia Gastrointestinal Y Hemato-Oncologia De Guatemala, S. A ( Site 3802)

Guatemala City, Guatemala

Servicios Médicos Oncológicos ( Site 3804)

Guatemala City, Guatemala

Orszagos Koranyi Pulmonologiai Intezet ( Site 1501)

Budapest, Hungary

Reformatus Pulmonologiai Centrum ( Site 1503)

Törökbálint, Hungary

Yitzhak Shamir Medical Center. ( Site 1709)

Beer Ya Akov, Israel

Shaare Zedek Medical Center ( Site 1706)

Jerusalem, Israel

Meir Medical Center. ( Site 1702)

Kfar Saba, Israel

Sheba Medical Center ( Site 1700)

Ramat Gan, Israel

Sourasky Medical Center ( Site 1705)

Tel Aviv, Israel

Azienda Santiaria dell'Alto Adige, comprensorio di Bolzano ( Site 1818)

Bolzano, Italy

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1807)

Meldola, Italy

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 1811)

Bergamo, Italy

Istituto Clinico Humanitas ( Site 1812)

Rozzano, Italy

Ospedale San Giuseppe Moscati ( Site 1816)

Statte, Italy

AOU Careggi ( Site 1801)

Florence, Italy

AOU Renato Dulbecco ( Site 1804)

Catanzaro, Italy

ASST Grande Ospedale Metropolitano Niguarda ( Site 1817)

Milan, Italy

A.O.R.N. Antonio Cardarelli ( Site 1810)

Naples, Italy

Policlinico San Matteo ( Site 1802)

Pavia, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 1809)

Verona, Italy

Aichi Cancer Center ( Site 2813)

Nagoya, Japan

Fujita Health University Hospital ( Site 2807)

Toyoake, Japan

Hirosaki University Hospital ( Site 2818)

Hirosaki, Japan

Ehime University Hospital ( Site 2800)

Tōon, Japan

Kurume University Hospital ( Site 2815)

Kurume, Japan

Gunma Prefectural Cancer Center ( Site 2802)

Ōta, Japan

National Hospital Organization Himeji Medical Center ( Site 2827)

Himeji, Japan

Kobe City Medical Center General Hospital ( Site 2811)

Kobe, Japan

Takarazuka City Hospital ( Site 2828)

Takarazuka, Japan

Kanazawa University Hospital ( Site 2805)

Kanazawa, Japan

St. Marianna University Hospital ( Site 2814)

Kawasaki, Japan

Yokohama Municipal Citizen's Hospital ( Site 2824)

Yokohama, Japan

Kanagawa Cancer Center ( Site 2820)

Yokohama, Japan

Saiseikai Matsusaka Municipal Hospital ( Site 2808)

Matsusaka, Japan

Tohoku University Hospital ( Site 2804)

Sendai, Japan

Kansai Medical University Hospital ( Site 2809)

Hirakata, Japan

National Hospital Organization Kinki-chuo Chest Medical Center ( Site 2822)

Sakai, Japan

Osaka Medical and Pharmaceutical University Hospital ( Site 2810)

Takatsuki, Japan

National Hospital Organization Ureshino Medical Center ( Site 2817)

Ureshino, Japan

Nippon Medical School Hospital ( Site 2819)

Bunkyo, Japan

Tokyo Metropolitan Komagome Hospital ( Site 2823)

Bunkyo, Japan

Tokyo Medical University Hospital ( Site 2829)

Shinjuku, Japan

National Center for Global Health and Medicine ( Site 2806)

Shinjuku, Japan

Chiba University Hospital ( Site 2812)

Chiba, Japan

National Hospital Organization Kyushu Medical Center ( Site 2801)

Fukuoka, Japan

Hiroshima City Hiroshima Citizens Hospital ( Site 2821)

Hiroshima, Japan

Saiseikai Kumamoto Hospital ( Site 2816)

Kumamoto, Japan

Osaka Metropolitan University Hospital ( Site 2826)

Osaka, Japan

Sultan Ismail Hospital ( Site 3103)

Johor Bahru, Malaysia

University Malaya Medical Centre ( Site 3107)

Wilayah Persekutuan, Malaysia

Hospital Tengku Ampuan Afzan ( Site 3109)

Kuantan, Malaysia

Hospital Pulau Pinang ( Site 3108)

George Town, Malaysia

Hospital Wanita and Kanak Kanak Sabah ( Site 3110)

Kota Kinabalu, Malaysia

Sarawak General Hospital ( Site 3101)

Kuching, Malaysia

Sunway Medical Centre ( Site 3106)

Petaling Jaya, Malaysia

Cengild G.I. Medical Centre ( Site 3112)

Kuala Lumpur, Malaysia

CANCER TREAMTENT CLINIC AND CLINICAL TRIALS SA DE CV ( Site 0801)

Guadalajara, Mexico

Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 0800)

Monterrey, Mexico

Scientia Investigacion Clinica S.C. ( Site 0804)

Chihuahua City, Mexico

Grupo Médico ASSET ( Site 0811)

Mexico City, Mexico

Amphia Ziekenhuis, locatie Breda Molengracht ( Site 1907)

Breda, Netherlands

Elisabeth-TweeSteden Ziekenhuis ( Site 1906)

Tilburg, Netherlands

Universitair Medisch Centrum Utrecht ( Site 1901)

Utrecht, Netherlands

IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0902)

Lima, Peru

Oncosalud ( Site 0901)

Lima, Peru

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2008)

Przemyśl, Poland

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2012)

Gliwice, Poland

Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2004)

Olsztyn, Poland

Spitalul Clinic Colțea ( Site 2102)

Bucharest, Romania

Institutul Oncologic Prof. Dr. I Chiricuta ( Site 2103)

Cluj-Napoca, Romania

SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2101)

Florești, Romania

Centrul de Oncologie "Sfântul Nectarie" ( Site 2107)

Craiova, Romania

Spitalul Municipal Schuller Ploiești ( Site 2106)

Ploieşti, Romania

SC ONCO CARD SRL ( Site 2109)

Brasov, Romania

SC MNT Healthcare Europe SRL ( Site 2105)

Bucharest, Romania

Delta Health Care SRL ( Site 2108)

Bucharest, Romania

Chonnam National University Hwasun Hospital ( Site 3502)

Jeollanam-do, South Korea

Pusan National University Yangsan Hospital ( Site 3504)

Yangsan, South Korea

Pusan National University Hospital ( Site 3501)

Busan, South Korea

Chungnam National University Hospital ( Site 3503)

Daejeon, South Korea

Kyung Hee University Medical Center ( Site 3500)

Seoul, South Korea

Korea University Guro Hospital ( Site 3505)

Seoul, South Korea

Institut Català d'Oncologia (ICO) - Badalona ( Site 2200)

Badalona, Spain

HOSPITAL CLÍNIC DE BARCELONA ( Site 2201)

Barcelona, Spain

Complejo Hospitalario Universitario A Coruna ( Site 2207)

A Coruña, Spain

HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 2202)

Majadahonda, Spain

Hospital General Universitario de Valencia ( Site 2204)

Valencia, Spain

Hospital Universitario Ramon y Cajal ( Site 2203)

Madrid, Spain

Hospital Universitario Virgen de Valme ( Site 2205)

Seville, Spain

Chang Gung Memorial Hospital- Chiayi ( Site 3611)

Chiayi City, Taiwan

Taipei Medical University Shuang Ho Hospital ( Site 3602)

New Taipei City, Taiwan

National Cheng Kung University Hospital ( Site 3604)

Tainan, Taiwan

MacKay Memorial Hospital ( Site 3609)

Taipei, Taiwan

National Taiwan University Cancer Center (NTUCC) ( Site 3601)

Taipei, Taiwan

Tri-Service General Hospital ( Site 3603)

Taipei, Taiwan

Adana Medical Park Seyhan Hastanesi ( Site 2407)

Seyhan, Turkey (Türkiye)

Hacettepe Universite Hastaneleri ( Site 2400)

Altindağ, Turkey (Türkiye)

Gazi Universitesi Tip Fakultesi ( Site 2404)

Ankara, Turkey (Türkiye)

Ankara Bilkent Sehir Hastanesi ( Site 2401)

Ankara, Turkey (Türkiye)

Trakya Universitesi Tip Fakultesi ( Site 2406)

Edirne, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 2403)

Istanbul, Turkey (Türkiye)

Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2504)

Chernivtsi, Ukraine

Communal noncommercial enterprise of Lviv regional council "Lviv oncological regional therapeutical ( Site 2507)

Lviv, Ukraine

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 2518)

Odesa, Ukraine

ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2517)

Rivne, Ukraine

Zhytomyr Regional Oncology Center ( Site 2519)

Zhytomyr, Ukraine

Shalimov Institute of Surgery and Transplantation Oncology department ( Site 2512)

Kyiv, Ukraine

Universal Clinic Oberig ( Site 2506)

Kyiv, Ukraine

Royal Cornwall Hospital ( Site 2614)

Truro, United Kingdom

Royal Free Hospital ( Site 2601)

London, United Kingdom

Queen Elizabeth Hospital Birmingham ( Site 2612)

Birmingham, United Kingdom

Leicester Royal Infirmary ( Site 2610)

Leicester, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.

You can help another person

We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.