Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This pilot study will assess the usefulness and potential effectiveness of using transcutaneous auricular vagus nerve stimulation (tVNS) for treating insomnia in adult survivors of childhood acute lymphoblastic leukemia (ALL). Participants will be randomized to receive either active (verum) or inactive (sham) nightly stimulation using a non-invasive earbud device over two time periods: 2 weeks and 8 weeks. The study will assess adherence to the intervention and estimate its effects on sleep quality, stress, and neurocognitive function. Primary Objective: Aim 1: To determine a) short-term and b) long-term feasibility of tVNS in terms of participation in ALL Survivors with moderate to severe insomnia. Aim 2: To estimate the effect size of tVNS on sleep quality, stress, and neurocognitive outcomes in ALL survivors with insomnia. Exploratory Objectives Aim 1: To investigate the onset of tVNS effect via actigraphy measures over the intervention epoch. Aim 2: To estimate the effect size of genetic variants on sleep quality within verum tVNS.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Przeżyłeś białaczkę (ALL) zdiagnozowaną przed 21. rokiem życia
- •Masz teraz 20-50 lat
- •Masz znaczące problemy ze snem (wynik w teście ≥8)
- •Masz dostęp do Wi-Fi i smartfona
- •Mówisz i rozumiesz angielski
- •Możesz świadomie wyrazić zgodę na uczestnictwo
✗ Disqualifies
- •Jesteś w ciąży lub planujesz ciążę
- •Masz wszczepiany rozrusznik serca lub inne urządzenie elektryczne w ciele
- •Bierzesz leki na zaburzenia poznawcze (np. stymulujące) lub na padaczkę
- •Miałeś problemy ze skórą podczas stymulacji ucha
- •Już używasz innego urządzenia na sen (np. CPAP)
- •Miałeś zaburzenia rytmu serca lub problemy z naczyniami krwionośnymi
- •W ciągu ostatniego roku miałeś napady padaczki
- •Uczestniczysz w innym badaniu na temat stymulacji mózgu
Simplified criteria — AI translation
Trial details
- Minimum age
- 20 Years
- Maximum age
- 50 Years
- Last updated (source)
- August 14, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
St. Jude Children's Research Hospital
Memphis, United States
Trial contact
Justin E Tanner, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/29/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.