A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is being conducted to learn more about the safety, tolerability, and effectiveness of an experimental treatment for metastatic prostate cancer called AZD6621. The study is split into different modules which will look at AZD6621 delivered by different methods. The study is also further split into 2 parts, Part A which will test different dose levels of AZD6621 to determine which doses are the best in terms of safety and side effects (dose escalation), and Part B will further test at least two AZD6621 doses in a larger group of participants (dose expansion).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent wyraża zgodę na udział w badaniu i przestrzega jego zasad.
- •Pacjent ma co najmniej 18 lat.
- •Zdiagnozowany rak prostaty z przerzutami.
- •Po kastracji chirurgicznej lub medycznej (poziom testosteronu poniżej określonego poziomu) lub przyjmuje terapię hormonalną.
- •Rak prostaty odporny na kastrację (postępujący mimo kastracji).
- •Poziom PSA (marker raka prostaty) powyżej określonego poziomu.
- •Próbka guza raka prostaty do badań jest wymagana.
- •Choroba postępowała w ciągu ostatnich 6 miesięcy (potwierdzona badaniami PSA lub obrazowymi).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 29, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (26)
Research Site
Orlando, United States
Research Site
Tampa, United States
Research Site
Boston, United States
Research Site
Grand Rapids, United States
Research Site
Commack, United States
Research Site
Providence, United States
Research Site
Brussels, Belgium
Research Site
Ghent, Belgium
Research Site
Toronto, Canada
Research Site
Québec, Canada
Research Site
Beijing, China
Research Site
Chengdu, China
Research Site
Guangzhou, China
Research Site
Nanjing, China
Research Site
Chūōku, Japan
Research Site
Hirakata-shi, Japan
Research Site
Kashiwa, Japan
Research Site
Amsterdam, Netherlands
Research Site
Maastricht, Netherlands
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Barcelona, Spain
Research Site
L'Hospitalet de Llobregat, Spain
Research Site
Madrid, Spain
Research Site
Cambridge, United Kingdom
Research Site
Manchester, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/31/2026.
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