Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests the addition of chemotherapy, with carboplatin and paclitaxel, or chemo-immunotherapy, with carboplatin, paclitaxel and cemiplimab to standard salvage surgery followed by post operative radiation therapy and cisplatin for high risk patients, for the treatment of patients with PD-L1 positive head and neck squamous cell carcinoma that has come back and spread to nearby tissue or lymph nodes after a period of improvement (locally recurrent) or is persistent. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Salvage surgery is surgery that takes place to remove tumor tissue after a failure of other treatment. High risk patients also receive radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding chemotherapy or chemo-immunotherapy to standard salvage surgery may kill more tumor cells than salvage surgery alone in patients with PD-L1 positive locally recurrent or persistent head and neck squamous cell carcinoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak płaskonabłonkowy głowy i szyi (w jamie ustnej, gardle, krtani), który powrócił lub się utrzymuje po leczeniu.
- •Rak posiada cechę PD-L1 (oznaczone w certyfikowanym laboratorium).
- •Pacjent kwalifikuje się do operacji z możliwością usunięcia guza.
- •Choroba jest widoczna w badaniach obrazowych i daje możliwość oceny leczenia (zgodnie z kryteriami RECIST 1.1).
- •Wiek powyżej 18 lat.
- •Ogólny stan zdrowia pozwala na leczenie (według skali ECOG 0-2).
✗ Disqualifies
- •Rak rozsiany do innych części ciała (przerzuty).
- •Znaczne zaangażowanie naczyń krwionośnych w okolicy guza, uniemożliwiające operację.
- •Brak wcześniejszej operacji w przypadku raka jamy ustnej, jeśli nastąpił nawrót lub utrzymywanie się choroby.
- •Niepowodzenie poprzedniego leczenia, które uniemożliwiałoby stosowanie obecnych terapii.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (87)
Banner University Medical Center - Tucson
Tucson, United States
University of Arizona Cancer Center-North Campus
Tucson, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, United States
Sutter Medical Center Sacramento
Sacramento, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
Emory Proton Therapy Center
Atlanta, United States
Emory University Hospital Midtown
Atlanta, United States
Rush MD Anderson Cancer Center
Chicago, United States
Rush MD Anderson Cancer Center at Rush Lisle
Lisle, United States
Memorial Hospital East
Shiloh, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Methodist Jennie Edmundson Hospital
Council Bluffs, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
University of Kansas Cancer Center
Kansas City, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
LSU Health Baton Rouge-North Clinic
Baton Rouge, United States
Our Lady of the Lake Physician Group
Baton Rouge, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
University of Michigan - Brighton Center for Specialty Care
Brighton, United States
Henry Ford Hospital
Detroit, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
University of Kansas Cancer Center - Briarcliff
Kansas City, United States
University of Kansas Cancer Center - North
Kansas City, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, United States
Nebraska Methodist Hospital
Omaha, United States
Cooper Hospital University Medical Center
Camden, United States
Jersey City Medical Center
Jersey City, United States
Monmouth Medical Center
Long Branch, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, United States
Rutgers New Jersey Medical School
Newark, United States
Community Medical Center
Toms River, United States
Stony Brook University Medical Center
Stony Brook, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
ProMedica Flower Hospital
Sylvania, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Clackamas Radiation Oncology Center
Clackamas, United States
Legacy Mount Hood Medical Center
Gresham, United States
Providence Newberg Medical Center
Newberg, United States
Providence Willamette Falls Medical Center
Oregon City, United States
Legacy Good Samaritan Hospital and Medical Center
Portland, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Legacy Meridian Park Hospital
Tualatin, United States
UPMC Hillman Cancer Center Erie
Erie, United States
Saint Vincent Hospital
Erie, United States
UPMC Cancer Center at UPMC Horizon
Farrell, United States
IRMC Cancer Center
Indiana, United States
Jefferson Hospital
Jefferson Hills, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, United States
Forbes Hospital
Monroeville, United States
UPMC Cancer Center - Monroeville
Monroeville, United States
UPMC Hillman Cancer Center - Monroeville
Monroeville, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Allegheny General Hospital
Pittsburgh, United States
UPMC-Saint Margaret
Pittsburgh, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
UPMC-Shadyside Hospital
Pittsburgh, United States
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, United States
UPMC Cancer Center at UPMC Northwest
Seneca, United States
UPMC Cancer Center-Washington
Washington, United States
UPMC Washington Hospital Radiation Oncology
Washington, United States
Wexford Health and Wellness Pavilion
Wexford, United States
Asplundh Cancer Pavilion
Willow Grove, United States
Medical University of South Carolina
Charleston, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, United States
Legacy Salmon Creek Hospital
Vancouver, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Drexel Town Square Health Center
Oak Creek, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Trial contact
Site Public Contact
Ricklie A. Julian
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jacob S. Thomas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christopher U. Jones
PRINCIPAL_INVESTIGATOR
Site Public Contact
Andrew C. Birkeland
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jennifer Gross
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Michael J. Jelinek
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brendan J. Knapp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Omar A. Karadaghy
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sagar G. Kansara
PRINCIPAL_INVESTIGATOR
Site Public Contact
Paul L. Swiecicki
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Samantha H. Tam
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Yungpo B. Su
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Brian Swendseid
PRINCIPAL_INVESTIGATOR
Site Public Contact
Dylan F. Roden
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Achuta K. Guddati
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mihir R. Patel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Chang Xia
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christina Henson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Dan S. Zuckerman
PRINCIPAL_INVESTIGATOR
Site Public Contact
Andrew Y. Kee
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Steven B. Chinn
PRINCIPAL_INVESTIGATOR
Site Public Contact
Larisa Greenberg
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Jennifer M. Johnson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Alexandra E. Kejner
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jennifer H. Choe
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Justine Yang-Bruce
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jennifer D. Bruening
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.