Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial
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About the trial
This randomized phase III trial examines whether lengthening the dosage interval in an adaptive manner for the prostate cancer drug lutetium 177 Lu PSMA RLT improves quality of life without decreasing lifespan when compared to the standard way this medication is given. This study is for patients with hormone resistant prostate cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body. Hormone resistant prostate cancer often has many cells containing a protein called prostate-specific membrane antigen (PSMA) on their surface. The normal cells in the prostate do not normally express as much PSMA protein on their surface as cancer cells. Lutetium 177 Lu PSMA RLT binds to the PSMA protein on the tumor cells. It builds up in these cells and gives off radiation that may kill them. Typically, this medication is given at the same dose every 6 weeks for up to 6 doses. In this trial, researchers want to see if treatment following the first two doses of lutetium 177 Lu PSMA RLT can be delayed until there is evidence of disease activity. This may be an effective way to improve quality of life without decreasing lifespan in patients with advanced prostate cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak prostaty (gruczolak)
- •Badanie PET/CT z PSMA wskazujące na obecność białka PSMA na komórkach rakowych
- •Poziom PSA powyżej 2.0 ng/mL
- •Zaawansowany, oporny na hormony rak prostaty, który mógł się rozprzestrzenić
- •Wcześniejsze leczenie hormonalne lub usunięcie jąder
- •Pacjent przyjmował wcześniej lek blokujący receptory androgenowe (np. enzalutamid, abirateron) i zakończył go co najmniej 4 tygodnie przed badaniem
✗ Disqualifies
- •Pacjent nie może być wcześniej leczony chemioterapią z użyciem taksanów (np. docetakselu) z powodu zaawansowanego raka prostaty opornego na hormony.
- •Możliwe są wcześniejsze terapie docetakselem, jeśli były stosowane w leczeniu hormonowrażliwego raka prostaty lub w innych sytuacjach (nie w opornej fazie).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 2, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (102)
Providence Alaska Medical Center
Anchorage, United States
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
City of Hope at Irvine Lennar
Irvine, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
CTCA at Southeastern Regional Medical Center
Newnan, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
Northwestern University
Chicago, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
Midwestern Regional Medical Center
Zion, United States
Mary Greeley Medical Center
Ames, United States
McFarland Clinic - Ames
Ames, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
McFarland Clinic - Boone
Boone, United States
Saint Anthony Regional Hospital
Carroll, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, United States
McFarland Clinic - Jefferson
Jefferson, United States
McFarland Clinic - Marshalltown
Marshalltown, United States
UI Healthcare Mission Cancer and Blood - Pella
Pella, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
The Iowa Clinic PC
West Des Moines, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, United States
Henry Ford Hospital
Detroit, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
Minnesota Oncology - Burnsville
Burnsville, United States
Cambridge Medical Center
Cambridge, United States
Mercy Hospital
Coon Rapids, United States
Fairview Southdale Hospital
Edina, United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, United States
Saint John's Hospital - Healtheast
Maplewood, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Hennepin County Medical Center
Minneapolis, United States
New Ulm Medical Center
New Ulm, United States
Fairview Northland Medical Center
Princeton, United States
North Memorial Medical Health Center
Robbinsdale, United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Saint Francis Regional Medical Center
Shakopee, United States
Lakeview Hospital
Stillwater, United States
Ridgeview Medical Center
Waconia, United States
Rice Memorial Hospital
Willmar, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, United States
Fairview Lakes Medical Center
Wyoming, United States
Heartland Regional Medical Center
Saint Joseph, United States
Missouri Baptist Medical Center
St Louis, United States
Community Hospital of Anaconda
Anaconda, United States
Billings Clinic Cancer Center
Billings, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Great Falls Clinic
Great Falls, United States
Hi-Line Sletten Cancer Center
Havre, United States
Benefis Helena Specialty Center
Helena, United States
Logan Health Medical Center
Kalispell, United States
Community Medical Center
Missoula, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
AtlantiCare Health Park-Cape May Court House
Cape May Court House, United States
AtlantiCare Surgery Center
Egg Harbor, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Roswell Park Cancer Institute
Buffalo, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Montefiore Medical Center-Einstein Campus
The Bronx, United States
Montefiore Medical Center - Moses Campus
The Bronx, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Sanford Bismarck Medical Center
Bismarck, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
MetroHealth Medical Center
Cleveland, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
Swedish Medical Center-First Hill
Seattle, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Cancer Center of Western Wisconsin
New Richmond, United States
Drexel Town Square Health Center
Oak Creek, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Memorial Hospital of Laramie County
Cheyenne, United States
Billings Clinic-Cody
Cody, United States
Trial contact
Shiva Baghaie, MPH
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.