Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial compares the effect of time-restricted eating (TRE) and glucagon-like peptide-1 (GLP1) receptor agonists (RA), semaglutide and tirzepatide, to an American Heart Association (AHA) heart healthy diet (HHD) intervention on heart and blood vessel health (cardiovascular system) and how the body processes food for energy (metabolic system) in prostate cancer patients undergoing androgen deprivation therapy (ADT). Prostate cancer patients who are receiving hormonal therapy (ADT) are at an increased risk of cardiovascular disease. This is thought to be due to treatment-related metabolic changes which may result in increased weight, body fat, insulin resistance and an increased risk of heart attack, stroke or other heart and blood vessel problems. TRE (also known as intermittent fasting) is an eating plan that alternates between fasting and non-fasting periods. This approach limits calorie intake to a specific window of time each day. GLP1-RAs, semaglutide and tirzepatide are in a class of medications called incretin mimetics. They work by helping the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. They also slow the movement of food through the stomach and may decrease appetite and cause weight loss. The AHA HHD guidelines may be an effective method to help people learn about following a heart healthy eating plan. This may lower their risk of cardiovascular disease. Metabolic interventions, TRE and GLP1-RA, may be more effective than an AHA HHD intervention alone in improving cardiovascular and metabolic health in prostate cancer patients undergoing ADT.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Mężczyzna w wieku 30-79 lat
- •Zgoda na uczestnictwo w badaniu i użycie materiału tkankowego z biopsji
- •Rak prostaty - pośredni stopień zagrożenia lub nawrót raka po operacji, z planem terapii hormonalnej przez 6 miesięcy
- •Wskaźnik BMI co najmniej 30 lub BMI co najmniej 27 z towarzyszącą chorobą (cukrzyca, nadciśnienie, zaburzenia lipidowe)
- •Dobrze ogólny stan zdrowia umożliwiający uczestnictwo w badaniu
- •Posługiwanie się angielskim, hiszpańskim lub mandaryńskim
✗ Disqualifies
- •Aktualnie stosowanie specjalnych diet (ketogeniczna, niskow??glowodanowa, paleo lub inne)
- •Aktualnie przyjmowanie leków GLP1
- •Niekontrolowana cukrzyca
- •Niemożliwość stosowania intermittent fasting
- •Przeciwwskazania do leków GLP1 (uczulenie, historia zapalenia trzustki, rak tarczycy w rodzinie)
- •Inne aktywne nowotwory lub choroby wykluczające uczestnictwo wg lekarza
Simplified criteria — AI translation
Trial details
- Minimum age
- 30 Years
- Maximum age
- 79 Years
- Last updated (source)
- August 17, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (1)
City of Hope Medical Center
Duarte, United States
Trial contact
Rose Li
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/18/2026.
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