A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
START-lung is an international, multicentre, single-arm phase II trial. Protocol treatment consists of tarlatamab administered as an intravenous infusion until disease progression according to RECIST v1.1 criteria, unacceptable toxicity, or patient decision, whichever comes first. The primary objective of the trial is to assess the clinical efficacy of tarlatamab, in terms of 12-month OS rate, in patients with ES-SCLC and ECOG PS 2 who have previously received only one line of platinum-etoposide doublet chemotherapy with immune-checkpoint inhibition and whose disease has progressed.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony zaawansowany rak płuc typu drobnokomórkowego
- •Poprzednia chemioterapia (tylko jedno leczenie) złożona z platyny i etopozidu wraz z immunoterapią
- •Choroba postępuje lub powróciła po pierwszym leczeniu
- •Wiek co najmniej 18 lat
- •Dobra funkcja nerek, wątroby i układu krwiotwórczego
- •Saturacja tlenu powyżej 90% bez dodatkowego tlenu
- •Wysyp musi być złożony i podpisany przed udziałem w badaniu
✗ Disqualifies
- •Przerzuty do mózgu powodujące objawy
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (19)
CHU Angers
Angers, France
Institut Bergonie
Bordeaux, France
Lyon - Centre Léon Bérard
Lyon, France
Hôpital Nord de Marseille
Marseille, France
Henry Dunant Hospital Center
Athens, Greece
Irccs Irst
Meldola, Italy
Instituto Europeo di Oncologia (IEO)
Milan, Italy
Santa Maria della Misericordia Hospital
Perugia, Italy
AO San Giovanni Addolorata
Roma, Italy
Istituto Nazionale Tumori "Regina Elena"
Roma, Italy
Hospital General Universitario Alicante
Alicante, Spain
Hospital de la Santa Creu I Sant Pau
Barcelona, Spain
Hospital Universitatrio Vall d'Hebron
Barcelona, Spain
ICO Hospitalet H. Duran I Reynals / H. Bellvitge
Barcelona, Spain
Hospital Universitatrio Puerta del Hierro
Madrid, Spain
Kantonsspital Baden
Baden, Switzerland
HFR - Hôpital cantonal
Fribourg, Switzerland
Geneva University Hospitals
Geneva, Switzerland
Kantonsspital St.Gallen
Sankt Gallen, Switzerland
Trial contact
Heidi Roschitzki, PhD
Susanne Roux
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/10/2026.
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