AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to measure the efficacy and safety of R-mini-CHOP × 2 followed by AZD0486 compared with R-mini-CHOP × 6 in elderly or unfit participants newly diagnosed with LBCL.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 80 lat lub więcej, albo 65-79 lat i uznany za słabego stanu do pełnego leczenia standardowego
- •Potwierdzona histologicznie diagnoza chłoniaka z dużych komórek B, nigdy wcześniej nie leczony
- •Widoczne guzy na badaniach PET i możliwe do zmierzenia
- •Stadium I-IV choroby
- •Ogólny stan zdrowia pozwalający na uczestnictwo (ECOG 0-2)
- •Prawidłowa funkcja szpiku, wątroby, nerek i serca
✗ Disqualifies
- •Inne choroby wykluczające udział w badaniu według lekarza
- •Chłoniak po przeszczepieniu, plazmoblastowy lub inne typy wyłączone z protokołu
- •Przerzuty do mózgu lub poważne choroby ośrodkowego układu nerwowego
- •Historia hemofagocytarnego chłoniaka lub aktywnego zapalenia
- •Aktywna lub niekontrolowana infekcja
- •Poważne nieprawidłowości serca
- •Wcześniejsze leczenie przeciwko chłoniakowi (poza kortykosteroidami)
- •Wymaganie stałego leczenia immunosupresyjnego z powodu autoimunologicznej choroby
Simplified criteria — AI translation
Trial details
- Minimum age
- 65 Years
- Maximum age
- 130 Years
- Last updated (source)
- October 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (82)
Research Site
Clayton, Australia
Research Site
Macquarie University, Australia
Research Site
Melbourne, Australia
Research Site
Nedlands, Australia
Research Site
Waratah, Australia
Research Site
Antwerp, Belgium
Research Site
Brussels, Belgium
Research Site
Ghent, Belgium
Research Site
Leuven, Belgium
Research Site
Roeselare, Belgium
Research Site
Yvoir, Belgium
Research Site
Porto Alegre, Brazil
Research Site
São Paulo, Brazil
Research Site
Calgary, Canada
Research Site
Victoria, Canada
Research Site
Hamilton, Canada
Research Site
Oshawa, Canada
Research Site
Ottawa, Canada
Research Site
Toronto, Canada
Research Site
Chicoutimi, Canada
Research Site
Beijing, China
Research Site
Changchun, China
Research Site
Chengdu, China
Research Site
Chongqing, China
Research Site
Fuzhou, China
Research Site
Guangzhou, China
Research Site
Guangzhou, China
Research Site
Guiyang, China
Research Site
Haikou, China
Research Site
Harbin, China
Research Site
Hefei, China
Research Site
Jinan, China
Research Site
Kunming, China
Research Site
Nanchang, China
Research Site
Nanning, China
Research Site
Nantong, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shenyang, China
Research Site
Wuhan, China
Research Site
Xiamen, China
Research Site
Berlin, Germany
Research Site
Dresden, Germany
Research Site
Rostock, Germany
Research Site
Hong Kong, Hong Kong
Research Site
Hong Kong, Hong Kong
Research Site
Lai Chi Kok, Hong Kong
Research Site
Akashi, Japan
Research Site
Bunkyō City, Japan
Research Site
Himeji-shi, Japan
Research Site
Kōtoku, Japan
Research Site
Kumamoto, Japan
Research Site
Matsumoto-shi, Japan
Research Site
Matsuyama, Japan
Research Site
Meguro-ku, Japan
Research Site
Nagoya, Japan
Research Site
Nagoya, Japan
Research Site
Okayama, Japan
Research Site
Osaka, Japan
Research Site
Osaka, Japan
Research Site
Otaki-Shi, Japan
Research Site
Sapporo, Japan
Research Site
Sunto-gun, Japan
Research Site
Yamagata, Japan
Research Site
Yokohama, Japan
Research Site
Kielce, Poland
Research Site
Krakow, Poland
Research Site
Lodz, Poland
Research Site
Lublin, Poland
Research Site
Wroclaw, Poland
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Ankara, Turkey (Türkiye)
Research Site
Antalya, Turkey (Türkiye)
Research Site
Istanbul, Turkey (Türkiye)
Research Site
Izmir, Turkey (Türkiye)
Research Site
Kocaeli, Turkey (Türkiye)
Research Site
Glasgow, Scotland, United Kingdom
Research Site
London, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Newcastle upon Tyne, United Kingdom
Research Site
Nottingham, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/10/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.