Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares the effect of vorasidenib to placebo in combination with usual treatment, temozolomide, in treating patients with newly diagnosed grade 3 astrocytoma after radiation. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid and may kill tumor cells and slow down or stop tumor growth. Vorasidenib citrate blocks the proteins made by the mutated IDH1 and IDH2 genes, which may help keep tumor cells from growing. It is a type of enzyme inhibitor and a type of targeted therapy. Adding vorasidenib to the usual treatment, temozolomide, may be more effective than temozolomide alone in treating patients with newly diagnosed grade 3 astrocytoma after radiation therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Diagnoza glejaka (astrocytoma) typu IDH-mutant, stopień 3.
- •Rak mózgu z potwierdzonymi specyficznymi mutacjami genetycznymi (IDH1 lub IDH2).
- •Brak usunięcia całego ramienia chromosomu 1p/19q (ważne dla określenia typu raka).
- •Brak przerzutów do rdzenia kręgowego lub opon mózgowo-rdzeniowych.
- •Pacjent nie przyjmował wcześniej chemioterapii ani innych celowanych terapii.
- •Wszczepienie lub biopsja wykonana nie wcześniej niż 6 miesięcy przed rozpoczęciem badania.
- •Zaplanowana radioterapia i późniejsza chemioterapia.
- •Wiek od 12 lat wzwyż.
✗ Disqualifies
- •Rak mózgu, który nie ma mutacji IDH.
- •Współistniejące inne poważne choroby, które mogą wpłynąć na wyniki leczenia.
- •Niewydolność narządów (np. wątroby, nerek) w znacznym stopniu.
- •Niewystarczające wyniki badań krwi (np. niskie białe krwinki, płytki krwi).
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (82)
City of Hope Comprehensive Cancer Center
Duarte, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
Yale University
New Haven, United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
OSF Saint Joseph Medical Center
Bloomington, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Illinois CancerCare-Carthage
Carthage, United States
University of Illinois
Chicago, United States
Illinois CancerCare-Eureka
Eureka, United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, United States
Illinois CancerCare-Galesburg
Galesburg, United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Illinois CancerCare-Macomb
Macomb, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, United States
OSF Saint Francis Medical Center
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Illinois CancerCare - Washington
Washington, United States
Midwestern Regional Medical Center
Zion, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Healthcare Mission Cancer and Blood - Pella
Pella, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
West Jefferson Medical Center
Marrero, United States
East Jefferson General Hospital
Metairie, United States
University Medical Center New Orleans
New Orleans, United States
Children's Hospital New Orleans
New Orleans, United States
MaineHealth Coastal Cancer Treatment Center
Bath, United States
MaineHealth Maine Medical Center - Portland
Portland, United States
MaineHealth Cancer Care Center of York County
Sanford, United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
University of Michigan - Brighton Center for Specialty Care
Brighton, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Northwell Health Imbert Cancer Center
Bay Shore, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Northwell Health/Center for Advanced Medicine
Lake Success, United States
Northern Westchester Hospital
Mount Kisco, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Stony Brook University Medical Center
Stony Brook, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
University of Cincinnati Cancer Center-West Chester
West Chester, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Christiana Care Health System-Concord Health Center
Chadds Ford, United States
UPMC Hillman Cancer Center Erie
Erie, United States
Forbes Hospital
Monroeville, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Allegheny General Hospital
Pittsburgh, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
UPMC-Shadyside Hospital
Pittsburgh, United States
Wexford Health and Wellness Pavilion
Wexford, United States
University of Vermont Medical Center
Burlington, United States
University of Vermont and State Agricultural College
Burlington, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
ProHealth D N Greenwald Center
Mukwonago, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Drexel Town Square Health Center
Oak Creek, United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, United States
UW Cancer Center at ProHealth Care
Waukesha, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Trial contact
Alexandra Alexandra LeVasseur
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.