RecruitingPhase II🇵🇱 PolandEN originalLung cancerMetastatic / advanced

A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

Researchers want to know if intismeran autogene (the study treatment) given with pembrolizumab and chemotherapy can treat metastatic treatment-naive squamous non-small cell lung cancer (NSCLC). Intismeran autogene is designed to help a person's immune system attack their specific cancer. The goal of this study is to learn if people who receive intismeran autogene with pembrolizumab and chemotherapy live longer overall and without the cancer growing or spreading compared to people who receive placebo with pembrolizumab and chemotherapy. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of the study treatment.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony diagnoza raka płuca (zaawansowany, z przerzutami)
  • Widoczne zmiany nowotworu możliwe do zmierzenia na badaniach obrazowych
  • Dostarczona próbka tkanki nowotworu (pobrana przy diagnozie lub później)
  • Nieprzyjemne skutki uboczne poprzedniego leczenia muszą się cofnąć
  • Zakażeni HIV muszą mieć chorobę kontrolowaną lekami
  • Stan ogólny pacjenta oceniony w ostatnich 7 dniach
  • Oczekiwana przeżywalność co najmniej 3 miesiące
  • Prawidłowe funkcjonowanie narządów wewnętrznych

✗ Disqualifies

  • Zakażenie HIV z historią mięsaka Kaposiego lub choroby Castelmana
  • Poprzednie leczenie szczepionką przeciwnowotworową
  • Poprzednie systemowe leczenie raka

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 10, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (54)

Moffitt Cancer Center ( Site 0021)

Tampa, United States

Washington University School of Medicine ( Site 0024)

St Louis, United States

Valley Health Systems - Ridgewood Campus ( Site 0010)

Paramus, United States

New York Oncology Hematology (NYOH) - Albany Medical Center ( Site 9001)

Albany, United States

Cleveland Clinic - Ohio ( Site 0016)

Cleveland, United States

Good Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0025)

Corvallis, United States

Tennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 9000)

Nashville, United States

Texas Oncology - Central/South Texas ( Site 8002)

Austin, United States

Virginia Cancer Specialists ( Site 0003)

Fairfax, United States

Swedish Medical Center-Swedish Cancer Institute ( Site 0023)

Seattle, United States

Hospital Italiano de Buenos Aires ( Site 0200)

Ciudad Autonoma de Buenos Aires., Argentina

Instituto Alexander Fleming ( Site 0201)

Ciudad Autonoma de Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0205)

Mar del Plata, Argentina

Clinica Adventista Belgrano ( Site 0206)

Caba., Argentina

Fundacion Estudios Clinicos ( Site 0207)

Rosario, Argentina

Sanatorio Parque ( Site 0203)

Rosario, Argentina

Westmead Hospital ( Site 0400)

Westmead, Australia

Princess Alexandra Hospital ( Site 0403)

Woolloongabba, Australia

One Clinical Research ( Site 0402)

Nedlands, Australia

Centro de Estudios Clínicos SAGA ( Site 0307)

Santiago, Chile

FALP ( Site 0300)

Santiago, Chile

Bradfordhill ( Site 0301)

Santiago, Chile

Bradford Hill Norte ( Site 0308)

Antofagasta, Chile

Centre Georges François Leclerc ( Site 0805)

Dijon, France

Institut de Cancérologie de l'Ouest ( Site 0801)

Angers, France

CHU GABRIEL MONTPIED ( Site 0802)

Clermont-Ferrand, France

Ospedale Santa Maria delle Croci-Dipartimento Oncoematologico ( Site 1004)

Ravenna, Italy

Ospedale San Raffaele-Oncologia Medica ( Site 1002)

Milan, Italy

Fondazione IRCCS Istituto Nazionale Dei Tumori ( Site 1000)

Milan, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1001)

Roma, Italy

Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 1101)

Poznan, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 1100)

Warsaw, Poland

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1102)

Przemyśl, Poland

National Cancer Center ( Site 0504)

Goyang-si, South Korea

Seoul National University Bundang Hospital ( Site 0500)

Seongnam-si, South Korea

Chungbuk National University Hospital-Internal medicine ( Site 0501)

Cheongju-si, South Korea

Asan Medical Center ( Site 0503)

Seoul, South Korea

Samsung Medical Center ( Site 0502)

Seoul, South Korea

ICO L Hospitalet ( Site 1311)

Hospitalet, Spain

Hospital Jerez de la Frontera-UGC Oncología ( Site 1315)

Jerez de la Frontera, Spain

Hospital Universitari Vall d''Hebron ( Site 1310)

Barcelona, Spain

Hospital Ramon y Cajal ( Site 1314)

Madrid, Spain

Hospital Clinico San Carlos... ( Site 1313)

Madrid, Spain

Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 1312)

Seville, Spain

China Medical University Hospital ( Site 0606)

Taichung, Taiwan

National Cheng Kung University Hospital ( Site 0601)

Tainan, Taiwan

Mackay Memorial Hospital ( Site 0604)

Taipei, Taiwan

National Taiwan University Cancer Center (NTUCC) ( Site 0600)

Taipei, Taiwan

Taipei Veterans General Hospital ( Site 0602)

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch ( Site 0605)

Taoyuan, Taiwan

Hacettepe Universitesi Tıp Fakultesi ( Site 1400)

Ankara, Turkey (Türkiye)

Memorial Ankara Hastanesi ( Site 1401)

Ankara, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi ( Site 1402)

Ankara, Turkey (Türkiye)

Koç Üniversitesi Hastanesi ( Site 1403)

Istanbul, Turkey (Türkiye)

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/11/2026.

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