Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This research study is for people who have locally advanced esophageal adenocarcinoma and are expected to receive chemotherapy. The purpose of this study is to compare the effectiveness of Liquid Nitrogen Spray Cryotherapy (LNSC) in addition to chemotherapy versus chemotherapy alone in the treatment of esophageal adenocarcinoma. LNSC is an FDA approved device that works by using liquid nitrogen to rapidly cool cancerous tissue causing cell damage. Participants in this study will be randomly assigned to either the "LNSC group" or the "No-LNSC group." Participants in the "LNSC group" will undergo 2 sessions of LNSC through an upper endoscopy. Participants in the "No-LNSC group," may undergo an endoscopy if needed for symptoms such as difficulty swallowing. Participation in the research will last about 4 months.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dorośli pacjenci z zaawansowanym rakiem przełyku typu gruczolakowatego
- •Pacjenci, którzy będą otrzymywać chemioterapię (schemat FLOT z opcjonalnym Durvalumabem)
- •Rak zaawansowany potwierdzony badaniami USG i PET-CT
✗ Disqualifies
- •Niemożliwość przeprowadzenia tuby do żołądka
- •Zaburzenia krzepnięcia krwi (wysokie INR lub niskie płytki krwi)
- •Niemożliwość wyrażenia świadomej zgody na udział
- •Zły ogólny stan zdrowia (wskaźnik wydolności ECOG powyżej 2)
- •Zbyt wysokie ryzyko powikłań związanych z zatrzymaniem leków przeciwzakrzepowych
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Cleveland Clinic Florida
Weston, United States
Trial contact
Tilak Shah, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/22/2026.
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