Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this research is to test an investigational device using ultrasound along with an investigational drug to see if it is useful in treating glioblastoma following standard of care therapy surgery and chemoradiation. This study is evaluating an experimental treatment for glioblastoma that uses an investigational drug (5-ALA) combined with a non-invasive ultrasound device (LIDU) to target tumor cells. Patients meeting the entry requirements to be in the study, will be equally randomly assigned to receive the study device plus the active study drug plus active ultrasound, or to a "sham" procedure where the ultrasound is not being activated and the study drug is a placebo (looks the same but does not contain active drug). Neither the patient or the investigator will know who is in the active group or not. Both groups will continue to receive the standard therapy of oral Temozolomide.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek od 18 do 80 lat
- •Nowo rozpoznany glejak mózgu potwierddzony badaniem histologicznym
- •Przeprowadzona wcześniej operacja usunięcia guza (nie sama biopsja)
- •Ukończona chemioterapia i radioterapia bez objawów progresji choroby
- •Liczba trombocytów co najmniej 50 000 komórek na mm³
- •Prawidłowa funkcja wątroby i nerek
- •Kobieta: w okresie menopauzalnym, bezpłodna chirurgicznie lub stosująca skuteczną antykoncepcję
- •Chęć udziału i zrozumienie badania
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 80 Years
- Last updated (source)
- July 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (11)
Dana Farber Cancer Institute
Boston, United States
Mayo Clinic
Rochester, United States
Albany Medical Center
Albany, United States
Dent Neurologic Institute
Buffalo, United States
Northwell Health
Long Island City, United States
New York Langone
New York, United States
Columbia University
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
University of Rochester
Rochester, United States
Ohio State University
Columbus, United States
Penn State Milton S. Hershey Medical Center
Hershey, United States
Trial contact
Ann-Marie VP, Clinical Operations
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/18/2026.
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