Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to adults with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing type of lung cancer that has spread widely in the body. To join the study, participants must meet the following conditions: * Be 18 years or older. * Have extensive-stage small cell lung cancer confirmed by lab tests. * Have not received chemotherapy or radiation for this type of lung cancer. * Be in good physical condition and have healthy organs based on medical tests. The study has two parts: * In the first part, researchers will check how safe the study medicine is and how well people tolerate it when given with chemotherapy. * In the second part, they will compare study medicine plus chemotherapy to another approved treatment (atezolizumab plus chemotherapy) to see which works better. Participants will receive the treatment through IV infusions (medicine given directly into a vein). The treatment will be given in repeated time periods called cycles. Some participants will continue receiving the study medicine alone after the initial treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza zaawansowanego raka płuc typu małokomórkowego
- •Wiek 18 lat lub więcej
- •Wcześniej nie otrzymywał chemioterapii ani napromieniania na tego typu raka
- •Przerwa co najmniej 6 miesięcy od ostatniej chemioterapii/napromieniania (jeśli wcześniej leczył się na wczesnym stadium)
- •Ma co najmniej jeden widoczny guz możliwy do pomiaru
- •Ogólny stan zdrowia pozwala na udział w badaniu
- •Prawidłowe funkcjonowanie wewnętrznych organów
✗ Disqualifies
- •Przerzuty raka do mózgu lub rdzenia kręgowego
- •Choroba opon mózgowych
- •Znaczne ryzyko krwawienia lub powstania nieprawidłowego prześwitu
- •Inne nowotwory w ciągu ostatnich 3 lat
- •Aktywne choroby autoimmunologiczne wymagające leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (73)
Highlands Oncology Group
Fayetteville, United States
Highlands Oncology Group
Rogers, United States
Highlands Oncology Group
Springdale, United States
BRCR Coral Springs
Coral Springs, United States
Mid Florida Hematology and Oncology Center
Orange City, United States
BRCR Global - Tamarac
Tamarac, United States
University Hospitals Cleveland Medical Center
Cleveland, United States
Texas Oncology - DFW
Arlington, United States
Texas Oncology - DFW
Arlington, United States
Texas Oncology - Gulf Coast
Beaumont, United States
Texas Oncology - DFW
Bedford, United States
Texas Oncology - DFW
Dallas, United States
Texas Oncology - DFW
Dallas, United States
Texas Oncology - DFW
Dallas, United States
Texas Oncology - DFW
Dallas, United States
Texas Oncology - DFW
Dallas, United States
Texas Oncology - DFW
Fort Worth, United States
Texas Oncology - San Antonio
Fredericksburg, United States
Texas Oncology - DFW
Grapevine, United States
Texas Oncology - Gulf Coast
Houston, United States
Texas Oncology - Gulf Coast
Houston, United States
US Oncology Investigational Product Center (IPC)
Irving, United States
US Oncology Investigational Products Center (IPC)
Irving, United States
US Oncology Investigational Products Center (IPC)
Irving, United States
Texas Oncology - San Antonio
New Braunfels, United States
Texas Oncology - Gulf Coast
Pearland, United States
Texas Oncology - DFW
Plano, United States
Texas Oncology - DFW
Plano, United States
Texas Oncology - San Antonio
San Antonio, United States
Texas Oncology - San Antonio
San Antonio, United States
Texas Oncology - San Antonio
San Antonio, United States
Texas Oncology - Gulf Coast
Sugar Land, United States
Texas Oncology - Gulf Coast
The Woodlands, United States
Texas Oncology - Gulf Coast
Webster, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Blacksburg, United States
Virginia Oncology Associates
Chesapeake, United States
Virginia Oncology Associates
Hampton, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Low Moor, United States
Virginia Oncology Associates
Newport News, United States
Virginia Oncology Associates
Norfolk, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Roanoke, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Salem, United States
Virginia Oncology Associates
Virginia Beach, United States
Virginia Oncology Associates
Williamsburg, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Wytheville, United States
Westmead Hospital
Westmead, Australia
Sunshine Coast University Hospital
Birtinya, Australia
Guangdong Provincial People's Hospital
Guangzhou, China
Fudan University Shanghai Cancer Center
Shanghai, China
Gustave Roussy
Villejuif, France
Hôpital Ambroise Paré
Boulogne-Billancourt, France
Marien Hospital Düsseldorf
Düsseldorf, Germany
Krankenhaus Nordwest GmbH
Frankfurt am Main, Germany
Centro di Riferimento Oncologico (CRO) IRCCS
Aviano, Italy
IRCCS Istituto Nazionale dei Tumori Regina Elena
Roma, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Italy
Kansai Medical University Hospital
Hirakata, Japan
Shizuoka Cancer Center
Nagaizumi-cho, Japan
Japanese Foundation for Cancer Research
Kotoku, Japan
Doctor's Center Hematology & Oncology Group
Manati, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office Mayaguez Medical Center
Mayagüez, Puerto Rico
Pan American Center for Oncology Trials, LLC
San Juan, Puerto Rico
Hospital Oncologico Dr. Isaac Gonzalez-Martinez
San Juan, Puerto Rico
HT Médica Jaen LAs Nieves
Jaén, Spain
Hospital Jerez de la Frontera
Jerez de la Frontera, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Parc de Salut Mar - Hospital del Mar
Barcelona, Spain
CETIR
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario de Jaen
Jaén, Spain
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Medical University Hospital
Taipei, Taiwan
Trial contact
Pfizer CT.gov Call Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.
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