Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to learn about the effects of study medicine (PF-08634404) when given alone or with another antibody (ipilimumab) for the treatment of a type of liver cancer called hepatocellular carcinoma (HCC) that is either locally advanced (spread to nearby tissues) or has spread to other parts of the body. To join the study, participants must meet the following conditions: * Be 18 years or older. * Have locally advanced or metastatic HCC. * Is not a candidate for complete surgical or loco-regional therapies. * Have not received any whole-body treatment for HCC. Participants will receive PF-08634404 either alone or in combination with ipilimumab. The medicine will be given through intravenous (IV) infusions, which means it will be administered directly into a vein. All treatments will take place at clinical trial sites, where trained medical staff will monitor participants during and after each visit.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Masz co najmniej 18 lat.
- •Masz zaawansowanego raka wątroby, który rozprzestrzenił się na inne części ciała lub sąsiednie tkanki.
- •Nie możesz być operowany lub poddany innym miejscowym leczeniom.
- •Nie otrzymałeś wcześniej żadnego ogólnoustrojowego leczenia raka wątroby.
- •Masz co najmniej jedną zmianę chorobową, którą można zmierzyć.
- •Twoje narządy (wątroba, nerki) działają wystarczająco dobrze.
✗ Disqualifies
- •Masz wodobrzusze (nadmiar płynu w jamie brzusznej) o umiarkowanym lub ciężkim nasileniu.
- •Miałeś w przeszłości encefalopatię wątrobową (zaburzenia mózgu związane z chorobą wątroby).
- •Masz aktywne przerzuty do mózgu lub rdzenia kręgowego.
- •Masz znaczące ryzyko krwawienia lub powstawania przetok (nienormalnych połączeń między narządami).
- •Chorowałeś na innego raka w ciągu ostatnich 3 lat.
- •Miałeś przeszczep narządu lub komórek macierzystych.
- •Masz aktywne choroby autoimmunologiczne wymagające leczenia w ciągu ostatnich 2 lat.
- •Miałeś poważne problemy z sercem lub naczyniami krwionośnymi w ciągu ostatnich 6 miesięcy.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (49)
Keck Hospital of USC
Los Angeles, United States
Los Angeles General Medical Center
Los Angeles, United States
USC/Norris Comprehensive Cancer Center / Investigational Drug Services
Los Angeles, United States
USC/Norris Comprehensive Cancer Center
Los Angeles, United States
Keck Medical Center of USC Pasadena
Pasadena, United States
Moffitt Cancer Center at Speros
Land O' Lakes, United States
Moffitt Cancer Center at SouthShore
Ruskin, United States
Moffitt Cancer Center - International Plaza
Tampa, United States
Moffitt Cancer Center - McKinley Campus
Tampa, United States
Moffitt Cancer Center
Tampa, United States
Moffitt McKinley Hospital
Tampa, United States
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel, United States
Memorial Hospital
Shiloh, United States
Siteman Cancer Center - Shiloh
Shiloh, United States
Allina Health Cancer Institute - Mercy Hospital
Coon Rapids, United States
Allina Health Cancer Institute - Abbott Northwestern Hospital
Minneapolis, United States
Allina Health Cancer Institute - United Hospital
Saint Paul, United States
Siteman Cancer Center - St. Peters
City of Saint Peters, United States
Siteman Cancer Center - West County
Creve Coeur, United States
Siteman Cancer Center - North County
Florissant, United States
Saint Luke's Cancer Institute
Kansas City, United States
Saint Luke's Hospital of Kansas City
Kansas City, United States
Siteman Cancer Center
St Louis, United States
Barnes-Jewish Hospital
St Louis, United States
Washington University School of Medicine - Siteman Cancer Center
St Louis, United States
Siteman Cancer Center - South County
St Louis, United States
Renown Health Medical Oncology
Reno, United States
Renown Office of Clinical Research
Reno, United States
Renown Regional Medical Center
Reno, United States
Duke Cancer Center Cary
Cary, United States
Duke Cancer Center - Investigational Chemotherapy Service
Durham, United States
Duke Cancer Center
Durham, United States
Duke University - Main Hospital and Clinics
Durham, United States
Duke Cancer Center Raleigh
Raleigh, United States
Virginia Mason Medical Center
Seattle, United States
Fred Hutchinson Cancer Center
Seattle, United States
University of Washington Medical Center- Montlake
Seattle, United States
Aichi Cancer Center
Nagoya, Japan
National Cancer Center Hospital East
Kashiwa, Japan
Kindai University Hospital- Osaka Medical Campus
Sakai, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
Pan American Center for Oncology Trials, LLC - Dorado Office
Dorado, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office
Mayagüez, Puerto Rico
Pan American Center for Oncology Trials, LLC - Ponce Office
Ponce, Puerto Rico
Pan American Center for Oncology Trials, LLC
San Juan, Puerto Rico
Taichung Veterans General Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Trial contact
Pfizer CT.gov Call Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.