Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is being done to learn more about a new medicine called PF-08634404 and how it works when used with other cancer medicines in people who have advanced solid tumors. An advanced solid tumor is a type of cancer that has spread beyond its original location and cannot be removed by surgery or cured with standard treatments. To join in the study, participants must: * Be 18 years or older * Participants with advanced non-small cell lung cancer (NSCLC), a type of lung cancer that has spread The study will look at: * Whether PF-08634404 is safe to use with other cancer medicines. * What side effects may happen. A side effect is anything the medicine does to your body that is not part of treating your disease. * Whether the combination of PF-08634404 and other cancer medicines can help treat solid tumors. The study has different parts, each testing PF-08634404 with a different cancer medicine: * Part A will test PF-08634404 with a medicine called sigvotatug vedotin. * Part B of the study will look at how well the new medicine PF-08634404 works when used together with another medicine. Participants will receive the study medicines through an intravenous (IV) infusion (injected into the vein) at the study clinic. All treatments will take place at clinical trial sites, where trained medical staff will monitor participants during and after each visit.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Zaawansowany rak płuca (rak rozprzestrzenił się poza początkowe miejsce)
- •Rak nie może być operacyjnie usunięty
- •Dostępny wynik badania statusu PD-L1
- •Można zmierzyć rozmiar nowotworu w badaniach obrazowych
- •Dobra ogólna kondycja zdrowotna (ocena ECOG 0 lub 1)
- •Prawidłowe funkcjonowanie wątroby, nerek i serca
✗ Disqualifies
- •Inne nowotwory zdiagnozowane w ciągu ostatnich 3 lat
- •Przerzuty do mózgu lub rdzenia kręgowego
- •Choroby autoimmunologiczne wymagające leczenia systemowego
- •Wcześniejsze chemioterapie dla tego raka
- •Poprzednia immunoterapia (z wyjątkiem specjalnych przypadków)
- •Wcześniejsze napromienianie klatki piersiowej w ostatnich 6 miesiącach
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (73)
Highlands Oncology Group, PA
Fayetteville, United States
Highlands Oncology Group, PA
Rogers, United States
Highlands Oncology Group, PA
Springdale, United States
Providence Medical Foundation
Fullerton, United States
Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion Center
Fullerton, United States
Providence St. Jude Medical Center
Fullerton, United States
Valkyrie Clinical Trials (Additional Site Pharmacy Storage Suite)
Los Angeles, United States
Valkyrie Clinical Trials
Los Angeles, United States
Mission Community Hospital (Satellite Site)
Panorama City, United States
Rocky Mountain Cancer Centers, LLP
Denver, United States
BRCR Medical Center Inc.
Coral Springs, United States
Mid Florida Hematology and Oncology Center
Orange City, United States
Orlando Health Ambulatory Care Center
Orlando, United States
Orlando Health Cancer Institute
Orlando, United States
Orlando Health Orlando Regional Medical Center
Orlando, United States
BRCR Global - Tamarac
Tamarac, United States
Hackensack University Medical Center
Hackensack, United States
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, United States
Newman Street Imaging
Hackensack, United States
John Theurer Cancer Center at JSUMC
Neptune City, United States
John Theurer Cancer Center at From Road
Paramus, United States
Heart Center Glenpointe
Teaneck, United States
Montefiore Medical Center- Montefiore Medical Park
The Bronx, United States
Oncology Associates of Oregon, P.C.
Eugene, United States
Dallas Cancer Specialists
Garland, United States
Southwest Oncology Associates
Houston, United States
Lumi Research
Houston, United States
US Oncology Investigational Products Center (IPC)
Irving, United States
Voyage Clinical
Sugar Land, United States
VCU Medical Center Gateway Building
Richmond, United States
Virginia Commonwealth University
Richmond, United States
VCU Health Stony Point
Richmond, United States
Massey Cancer Center Clinical & Translational Research Lab
Richmond, United States
Virginia Commonwealth University
Richmond, United States
VCU Health Community Memorial Hospital
South Hill, United States
VCU Health Tappahannock Hospital
Tappahannock, United States
Beijing Cancer hospital
Beijing, China
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China
Shanghai Chest Hospital
Shanghai, China
Taizhou Hospital of Zhejiang Province
Taizhou, China
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, France
Centre Georges François Leclerc
Dijon, France
Institut Paoli-Calmettes
Marseille, France
Marien Hospital Düsseldorf
Düsseldorf, Germany
Azienda Sanitaria Territoriale Pesaro Urbino (AST PU)
Fano, Italy
IRCCS Istituto Nazionale dei Tumori Regina Elena
Roma, Italy
Ospedale Isola Tiberina - Gemelli Isola
Roma, Italy
Kansai Medical University Hospital
Hirakata, Japan
Shizuoka Cancer Center
Nagaizumi-cho, Japan
Pan American Center for Oncology Trials, LLC
Rio Piedras, Puerto Rico
BRCR Global Puerto Rico - Hato Rey
San Juan, Puerto Rico
HT Médica Jaen LAs Nieves
Jaén, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Jerez de la Frontera
Jerez de la Frontera, Spain
Hospital Nuestra Señora del Rosario
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Spain
Clínica Radiólogica Mario Gallegos
Málaga, Spain
Fundación Instituto Valenciano de Oncología
Valencia, Spain
Hospital Universitario Puerta del Mar
Cadiz, Spain
Hospital Universitario San Cecilio
Granada, Spain
Hospital Universitario de Jaen
Jaén, Spain
Hospital Clinico San Carlos
Madrid, Spain
Cadpet Malaga
Málaga, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
VIVO Capuchinos
Seville, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung City, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Mackay Memorial Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Trial contact
Pfizer CT.gov Call Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.
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