Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Ogólny stan zdrowia pozwala na codzienne aktywności.
- •Przewidywany czas życia wynosi co najmniej 6 miesięcy.
- •Rak jelita grubego z przerzutami potwierdzony badaniami.
- •Brak wcześniejszego leczenia raka jelita grubego z przerzutami.
- •Istnienie co najmniej jednej zmiany widocznej w badaniach, która może być mierzona.
✗ Disqualifies
- •Choroba z wysoką niestabilnością mikrosatelitarną (MSI-H) lub z deficytem naprawy niesparowanych zasad (dMMR).
- •Wykryta mutacja genu BRAF V600E.
- •Obecnie występujące znaczące problemy z powodu niedrożności jelit.
- •Płyn w jamie brzusznej wymagający nakłucia w ciągu ostatnich 30 dni.
- •Wcześniejsze leczenie immunoterapią lub lekami antyangiogennymi z powodu raka jelita grubego.
- •Choroba zapalna jelit (np. choroba Leśniowskiego-Crohna, wrzodziejące zapalenie jelita grubego lub przewlekła biegunka).
- •Rak, który można usunąć chirurgicznie.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (140)
Clinical Study Site
Mobile, United States
Clinical Study Site
Tuscaloosa, United States
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Goodyear, United States
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Beverly Hills, United States
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Beverly Hills, United States
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Cerritos, United States
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Corona, United States
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Duarte, United States
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Fountain Valley, United States
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Huntington Beach, United States
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Irvine, United States
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Irvine, United States
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Los Angeles, United States
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Los Angeles, United States
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Los Angeles, United States
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Murrieta, United States
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Orange, United States
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Pasadena, United States
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Torrance, United States
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Upland, United States
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West Hollywood, United States
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Hartford, United States
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New Haven, United States
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Norwich, United States
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Newark, United States
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Hialeah, United States
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Miami, United States
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Orlando, United States
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Plantation, United States
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Port Saint Lucie, United States
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St. Petersburg, United States
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Tamarac, United States
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Atlanta, United States
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Atlanta, United States
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Newnan, United States
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Chicago, United States
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Elmhurst, United States
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O'Fallon, United States
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Fort Wayne, United States
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Indianapolis, United States
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Westwood, United States
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Edgewood, United States
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New Orleans, United States
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Baltimore, United States
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Detroit, United States
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Saint Louis Park, United States
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Springfield, United States
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Billings, United States
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Lincoln, United States
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Lebanon, United States
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New Brunswick, United States
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Mineola, United States
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New York, United States
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Rochester, United States
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Syracuse, United States
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The Bronx, United States
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White Plains, United States
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Akron, United States
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Canton, United States
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Cincinnati, United States
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Cincinnati, United States
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Cleveland, United States
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Cleveland, United States
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Mayfield Heights, United States
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Oklahoma City, United States
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Lebanon, United States
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Philadelphia, United States
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Philadelphia, United States
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Pittsburgh, United States
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Providence, United States
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Greenville, United States
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Hermitage, United States
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Dallas, United States
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Dallas, United States
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Fort Worth, United States
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Tyler, United States
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Salt Lake City, United States
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Charlottesville, United States
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Fairfax, United States
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Spokane, United States
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Tacoma, United States
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Charleston, United States
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Madison, United States
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Brussels, Belgium
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Ghent, Belgium
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Haine-Saint-Paul, Belgium
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Kortrijk, Belgium
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Toronto, Canada
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Montreal, Canada
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Regina, Canada
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Hradec Králové, Czechia
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Prague, Czechia
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Lyon, France
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Montpellier, France
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Nantes, France
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Paris, France
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Paris, France
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Pierre-Bénite, France
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Poitiers, France
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Strasbourg, France
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Bonn, Germany
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Hamburg, Germany
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Hamburg, Germany
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Meldola, Italy
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Osaka, Japan
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Aichi, Japan
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Chiba, Japan
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Ehime, Japan
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Fukuoka, Japan
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Gifu, Japan
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Hiroshima, Japan
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Hokkaido, Japan
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Kawasaki, Japan
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Osaka, Japan
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Saitama, Japan
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Sendai, Japan
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Shizuoka, Japan
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Tokyo, Japan
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Tokyo, Japan
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Toyama, Japan
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Yokohama, Japan
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Rzeszów, Poland
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Warsaw, Poland
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Rio Piedras, Puerto Rico
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A Coruña, Spain
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Madrid, Spain
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Palma de Mallorca, Spain
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Santander, Spain
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Valencia, Spain
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Valencia, Spain
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Valencia, Spain
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Canterbury, United Kingdom
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London, United Kingdom
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Aberdeen, United Kingdom
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Edinburgh, United Kingdom
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Manchester, United Kingdom
Trial contact
Ning Chang, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.
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