Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Masz co najmniej 18 lat i wyraziłeś zgodę na udział.
- •Twój ogólny stan zdrowia pozwala na leczenie (punktacja 0 lub 1 w skali ECOG).
- •Masz potwierdzony w badaniu histologicznym rak trzustki, który został w całości usunięty operacyjnie (R0/R1) i nie ma oznak nawrotu choroby ani przerzutów.
- •Otrzymałeś chemioterapię przed lub po operacji (lub obie).
- •Zakończyłeś ostatnie leczenie w ciągu ostatnich 12 tygodni.
- •Twoje narządy (szpik kostny, wątroba, nerki) działają prawidłowo.
- •Badania wykazały obecność konkretnej mutacji RAS w guzie.
- •Możesz przyjmować leki doustnie.
✗ Disqualifies
- •Otrzymałeś wcześniej leczenie celowane w mutację RAS.
- •Masz schorzenia, które mogą utrudniać przyjmowanie lub wchłanianie leku z badania.
- •Miałeś dużą operację w ciągu ostatnich 28 dni.
- •Nie możesz lub nie chcesz przyjeżdżać na wizyty kontrolne wymagane w badaniu.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 23, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (78)
Mayo Clinic
Phoenix, United States
HonorHealth Research Institute
Scottsdale, United States
UC San Diego Moores Cancer Center
La Jolla, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, United States
University of California, Los Angeles
Los Angeles, United States
Stanford Cancer Institute
Palo Alto, United States
University of California, Davis Comprehensive Cancer Center
Sacramento, United States
University of California, San Francisco
San Francisco, United States
Rocky Mountain Cancer Centers, LLP
Lakewood, United States
Hartford Healthcare
Hartford, United States
Mayo Clinic
Jacksonville, United States
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center
Miami, United States
Florida Cancer Specialists
St. Petersburg, United States
Piedmont Physicians Medical Oncology Atlanta
Atlanta, United States
Winship Cancer Institute, Emory University
Atlanta, United States
Community Health Network
Indianapolis, United States
University of Kansas Medical Center Research Institute, Inc.
Lawrence, United States
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital
Baltimore, United States
Massachusetts General Hospital
Boston, United States
Dana Farber Cancer Institute (DFCI)
Boston, United States
Mayo Clinic Cancer Center
Rochester, United States
Saint Luke's Cancer Institute
Kansas City, United States
University of Nebraska Medical Center
Omaha, United States
Comprehensive Cancer Centers of Nevada
Las Vegas, United States
Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center
New York, United States
Icahn School of Medicine at Mount Sinai
New York, United States
Columbia University Medical Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
University of Rochester Medical Center
Rochester, United States
Duke Cancer Center
Durham, United States
Taylor Cancer Research Center
Maumee, United States
University of Pennsylvania, Abramson Cancer Center
Philadelphia, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
Avera Cancer Institute
Sioux Falls, United States
SCRI Oncology Partners
Nashville, United States
Texas Oncology - DFW
Dallas, United States
University of Texas, Southwestern Medical Center
Dallas, United States
University of Texas MD Anderson Cancer Center
Houston, United States
Texas Oncology - Northeast Texas
Longview, United States
University of Utah, Huntsman Cancer Institute
Salt Lake City, United States
Virginia Cancer Specialists
Fairfax, United States
Fred Hutchison Cancer Center
Seattle, United States
Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, United States
Hopital Claude Huriez - CHU Lille
Lille, France
CRLCC Eugene Marquis
Rennes, France
Hôpital Paul Brousse
Villejuif, France
Institut Gustave Roussy
Villejuif, France
Institut Paoli Calmettes
Marseille, France
Krankenhaus Nordwest GmbH
Frankfurt, Germany
Universitaetsklinikum Heidelberg
Heidelberg, Germany
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
IEO - Instituto Europeo di Oncologia
Milan, Italy
IOV - Istituto Oncologico Veneto IRCCS
Padova, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
Centro Ricerche Cliniche di Verona s.r.l.
Verona, Italy
Kanagawa Cancer Center
Yokohama, Japan
National Cancer Center Hospital East
Chiba, Japan
Kyushu University Hospital
Fukuoka, Japan
Kyoto University Hospital
Kyoto, Japan
National Cancer Center Hospital
Tokyo, Japan
Cancer Institute Hospital of JFCR
Tokyo, Japan
Pan American Oncology Trials, LLC
San Juan, Puerto Rico
Dong-A University Hospital
Busan, South Korea
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Clinica Universidad de Navarra
Pamplona, Spain
Hospital Universitari Vall d'Hebron - VHIO
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Virgen del Rocio
Seville, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain
University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre
Birmingham, United Kingdom
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool, United Kingdom
The Royal Marsden NHS Foundation Trust, Royal Marsden Hospital-London
London, United Kingdom
Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Trial contact
Revolution Medicines Study Director
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
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