KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers want to learn if using a study medicine called MK-1084 can help treat NSCLC. MK-1084 is a type of treatment called targeted therapy for the Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C gene change. The goal of this study is to learn about the safety of MK-1084 and to learn how many people have the cancer get smaller or go away during the study treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór płuc typu NSCLC, zaawansowany lub z przerzutami
- •Obecność mutacji KRAS G12C w tkance nowotworu lub we krwi
- •Możliwość pobrania próbki tkanki nowotworu do badania
- •Wyleczenie się z działań niepożądanych poprzednich terapii (stopień ≤1 lub powrót do stanu wyjściowego)
- •Jeśli zarażony HIV - virus kontrolowany lekami przeciwwirusowymi
- •Jeśli zarażony wirusem zapalenia wątroby B - bez wykrywanego wirusa, leczony co najmniej 4 tygodnie
- •Jeśli zarażony wirusem zapalenia wątroby C - bez wykrywanego wirusa
✗ Disqualifies
- •Diagnoza małokomórkowego raka płuca lub obecność małokomórkowych elementów w guzie
- •Zarażenie HIV z historią mięsaka Kaposiego lub choroby Castelmana
- •Aktywne zapalenie jelit wymagające leków immunosupresyjnych
- •Niekontrolowane poważne choroby serca lub naczyń mózgowych (niewydolność, arytmia, zawał w ostatnich 6 miesiącach)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (34)
Clermont Oncology Center ( Site 0041)
Clermont, United States
Sanford Health Roger Maris Cancer Center ( Site 0039)
Fargo, United States
Sanford Cancer Center Oncology Clinic ( Site 0038)
Sioux Falls, United States
Fundacion Arturo Lopez Perez ( Site 0167)
Santiago, Chile
Centro de Oncología de Precisión ( Site 0160)
Santiago, Chile
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 0318)
Nanjing, China
West China Hospital, Sichuan University ( Site 0315)
Chengdu, China
Kuopion Yliopistollinen Sairaala ( Site 0261)
Kuopio, Finland
Vaasan Keskussairaala ( Site 0263)
Vaasa, Finland
Turku University Hospital ( Site 0262)
Turku, Finland
HYKS Syöpätautien klinikka ( Site 0260)
Helsinki, Finland
Hong Kong Integrated Oncology Centre ( Site 0232)
Central, Hong Kong
Hong Kong United Oncology Centre ( Site 0231)
Kowloon, Hong Kong
Queen Mary Hospital ( Site 0230)
Pokfulam, Hong Kong
Fondazione IRCCS Istituto Nazionale Dei Tumori ( Site 0175)
Milan, Italy
Deventer Ziekenhuis ( Site 0272)
Deventer, Netherlands
Leids Universitair Medisch Centrum ( Site 0273)
Leiden, Netherlands
Severance Hospital Yonsei University Health System ( Site 0080)
Seoul, South Korea
Hospital Universitario Virgen de la Macarena ( Site 0093)
Seville, Spain
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 0351)
Bangkok, Thailand
Erciyes University ( Site 0145)
Talas, Turkey (Türkiye)
Baskent University Dr. Turgut Noyan Research and Training Center ( Site 0141)
Adana, Turkey (Türkiye)
Koç Üniversitesi Hastanesi ( Site 0142)
Adana, Turkey (Türkiye)
Liv Hospital Ankara ( Site 0146)
Ankara, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 0140)
Ankara, Turkey (Türkiye)
COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 0139)
Cherkasy, Ukraine
Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 0465)
Kryvyi Rih, Ukraine
Communal Non-Commercial Enterprise "Prykarpatski Clinical On-Surgery department #2 ( Site 0132)
Ivano-Frankivsk, Ukraine
Limited Liability Company Ukrainian Center of Tomotherapy-Department of Chemotherapy ( Site 0467)
Kropyvnytskyi, Ukraine
Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 0133)
Lviv, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncolog-Cardiothoracic department ( Site 0131)
Vinnitsya, Ukraine
Uzhhorod Municipal Multidisciplinary Clinical Hospital of Uzhhorod City Council ( Site 0137)
Uzhhorod, Ukraine
VISION PARTNER Medical Centre ( Site 0135)
Kyiv, Ukraine
LIMITED LIABILITY COMPANY "MEDICAL CENTER "DOBROBUT-CLINIC" ( Site 0138)
Kyiv, Ukraine
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/11/2026.
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