PET Guided Dose Reduction for InvOlved Site Radiotherapy In Early sTage Unfavourable Hodgkin Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The final analysis of GHSG HD11 study (not PET driven) showed that 30 Gy IFRT still remains the standard dose after 4 ABVD. Early PET negativity might allow safe radiation de-escalation in patients achieving a metabolic complete response after 2 ABVD. The aim of Priority trial is to explore whether radiotherapy could be safely deescalated to 20 Gy without loss of efficacy in patients treated with four cycles of ABVD who achieved complete metabolic response after the first two cycles.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Potwierdzona histologicznie choroba Hodgkina w stadium I lub II (niekorzystne)
- •Nie było wcześniejszego leczenia chłoniaka Hodgkina
- •Ogólny stan zdrowia pozwalający na uczestnictwo (0-2 w skali ECOG)
- •Pozytywny obraz w PET-CT pokazujący aktywne ogniska choroby
- •Prawidłowe wyniki badań krwi i funkcji nerek/wątroby
- •Zgoda na stosowanie skutecznej antykoncepcji przez 6 miesięcy po leczeniu (kobiety i mężczyźni)
- •U kobiet zdolnych do zajścia w ciążę - ujemny test ciążowy na początku badania
✗ Disqualifies
- •Stadium II B, III lub IV choroby
- •Specjalne podtypy histologiczne chłoniaka Hodgkina
- •Aktywne zakażenie wirusem zapalenia wątroby B lub C
- •Zakażenie wirusem HIV
- •Poprzednie leczenie chemioterapią lub radioterapią
- •Nowotwór złośliwy w ostatnich 5 latach (poza rakiem skóry)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (38)
A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia
Alessandria, Italy
A.O.R.N. G Moscati - U.O.C. Ematologia e Terapie cellulari avanzate
Avellino, Italy
IRCCS Centro Riferimento Oncologico - S.O.C. Oncologia medica e dei tumori immuno-correlati
Aviano, Italy
ASST Papa Giovanni XXIII - S.C. Ematologia
Bergamo, Italy
Clinica Humanitas Gavazzeni - U.O. Oncologia Medica
Bergamo, Italy
ASST Spedali Civili - S.C. Ematologia
Brescia, Italy
ARNAS "Brotzu" P.O. Businco - S.C. Ematologia e TMO
Cagliari, Italy
I.R.C.C.S. Istituto di Candiolo - FPO
Candiolo, Italy
ARNAS Garibaldi - U.O.C. Ematologia
Catania, Italy
A.O. S. Croce e Carle - S.C. Ematologia
Cuneo, Italy
A.S.L. Toscana Centro - SOC Oncoematologia
Florence, Italy
Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia
Florence, Italy
IRCCS Policlinico S. Martino - U.O. Ematologia e terapie cellulari
Genova, Italy
ASL Latina Ospedale S. Maria Goretti - UOC Ematologia con trapianto
Latina, Italy
ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia
Milan, Italy
IRCCS Fondazione Istituto Nazionale Tumori - S.C. Ematologia
Milan, Italy
A.O.U. Ospedale Maggiore della Carità - S.C.D.U. Ematologia
Novara, Italy
A.O.U. di Padova - U.O.C. Ematologia
Padova, Italy
I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1
Padova, Italy
A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia
Palermo, Italy
IRCCS Fondazione Policlinico S. Matteo - S.C. Ematologia 1
Pavia, Italy
A.O. Ospedale S. Maria della Misericordia - Ematologia
Perugia, Italy
AUSL di Piacenza Ospedale Guglielmo da Saliceto - U.O.C. Ematologia e centro trapianti
Piacenza, Italy
AUSL di Ravenna Osp. S. Maria delle Croci - U.O.C. Ematologia
Ravenna, Italy
AUSL IRCCS Arcispedale S. Maria Nuova - S.C. Ematologia
Reggio Emilia, Italy
A.O.U. Policlinico Umberto I - U.O.C Ematologia
Roma, Italy
A.O.U. Sant'Andrea - U.O.C. Ematologia
Roma, Italy
Fondazione Policlinico Campus Bio-Medico - U.O.C. Ematologia e trapianto di cellule staminali
Roma, Italy
IRCCS Humanitas - U.O. Ematologia
Rozzano, Italy
IRCCS Fondazione Casa Sollievo della Sofferenza - UOC Ematologia e Trapianto di Cellule Staminali Ematopoietiche
San Giovanni Rotondo, Italy
A.O.U. Senese - U.O.C. Ematologia
Siena, Italy
A.O. Santa Maria - S.C. Oncoematologia
Terni, Italy
A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia U
Torino, Italy
A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia
Torino, Italy
ULSS 2 Ospedale Ca' Foncello - U.O.C. Ematologia
Treviso, Italy
A.S.U. Giuliano Isontina - S.C. Ematologia
Trieste, Italy
A.S.U. Friuli Centrale - Clinica Ematologica
Udine, Italy
A.O.U.I. di Verona - U.O.C. Ematologia
Verona, Italy
Trial contact
Uffici Studi FIL
Uffici Studi FIL
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/28/2026.
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