A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to investigate the efficacy and safety of fixed-duration sonrotoclax (also known as BGB-11417) plus zanubrutinib (also known as BGB-3111) (SZ) compared with fixed-duration of venetoclax plus acalabrutinib (AV) in participants with previously untreated chronic lymphocytic leukemia (CLL).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dorosły pacjent z potwierdzonym rozpoznaniem przewlekłej białaczki limfocytowej wymagający leczenia
- •Ogólny stan zdrowia oceniony na 0, 1 lub 2 w skali ECOG
- •Mierzalna choroba widoczna w tomografii CT lub rezonansie MRI
- •Prawidłowe funkcjonowanie szpiku kostnego i organów wewnętrznych
✗ Disqualifies
- •Poprzednie leczenie systemowe białaczki limfocytowej
- •Podejrzenie lub historia transformacji Richtera (przemiany nowotworu)
- •Przerzuty do układu nerwowego
- •Historia potwierdzonych zakaźnych zmian w mózgu (PML)
- •Niekontrolowane wysokie ciśnienie krwi lub znaczne choroby serca
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 23, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (91)
Stanford Cancer Institute
Palo Alto, United States
Northwestern University
Chicago, United States
Fred Hutchinson Cancer Research Center
Seattle, United States
Blacktown Cancer and Haematology Centre
Blacktown, Australia
Concord Repatriation General Hospital
Concord, Australia
Genesiscare North Shore
St Leonards, Australia
Princess Alexandra Hospital
Woolloongabba, Australia
Monash Health
Clayton, Australia
Austin Health
Heidelberg, Australia
Cabrini Hospital Malvern
Malvern, Australia
The Alfred Hospital
Melbourne, Australia
Instituto Dor de Pesquisa E Ensino Distrito Federal
Brasília, Brazil
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
Porto Alegre, Brazil
Instituto Dor de Pesquisa E Ensino Sao Paulo
São Paulo, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, Brazil
Bc Cancer Victoria
Victoria, Canada
Juravinski Cancer Centre
Hamilton, Canada
Ciusss Nim Hscm
Montreal, Canada
Jewish General Hospital
Montreal, Canada
Ciusss de Lestrie Chus
Sherbrooke, Canada
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
Québec, Canada
Peking Union Medical College Hospital
Beijing, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, China
Zhujiang Hospital of Southern Medical University
Guangzhou, China
Sun Yat Sen University Cancer Center Huangpu Branch
Guangzhou, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, China
Guizhou Provincial Peoples Hospital
Guiyang, China
Harbin Medical University Cancer Hospital
Harbin, China
Henan Cancer Hospital
Zhengzhou, China
The Second Xiangya Hospital of Central South University
Changsha, China
Jiangsu Province Hospital
Nanjing, China
Affiliated Hospital of Nantong University
Nantong, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
The Second Affiliated Hospital of Xian Jiaotong University
Xi'an, China
Shandong Provincial Hospital
Jinan, China
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital
Chengdu, China
Institute of Hematology and Hospital of Blood Disease
Tianjin, China
First Affiliated Hospital of Kunming Medical University
Kunming, China
The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan
Hangzhou, China
Fakultni Nemocnice Brno
Brno, Czechia
Fakultni Nemocnice Hradec Kralove
Hradec Králové, Czechia
Fakultni Nemocnice Olomouc
Olomouc, Czechia
Fakultni Nemocnice Ostrava
Ostrava, Czechia
Fakultni Nemocnice Plzen
PLZE, Czechia
Vseobecna Fakultni Nemocnice V Praze
Prague, Czechia
Centre de Lutte Contre Le Cancer Institut Bergonie
Bordeaux, France
Chu Clermont Ferrand Therapie Cellulaire and Hematolo
ClermontFerrand, France
Centre Hospitalier Le Mans
Le Mans, France
Hopital Claude Huriez Chu Lille
Lille, France
Centre Leon Berard
Lyon, France
Chu Montpellier Hopital Saint Eloi
Montpellier, France
Iuc Toulouse Oncopole
Toulouse, France
Donauisar Klinikum Deggendorf Klinik Fur Onkologie Und Hamatologie
Deggendorf, Germany
Centrum Fur Haematologie Und Onkologie Bethanien
Frankfurt am Main, Germany
Klinikum St Elisabeth Straubing Gmbh Mvz Klinikum Straubing Gmbh
Straubing, Germany
Irccs Azienda Ospedaliero Universitaria Bologna
Bologna, Italy
Aou Careggi, Servizio Sanitario Toscana
Florence, Italy
Ospedale San Raffaele
Milan, Italy
Azienda Ospedaliera Di Padova
Padova, Italy
Fondazione Policlinico Universitario Agostino Gemelli
Roma, Italy
Flevoziekenhuis
Almere Stad, Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
Hagaziekenhuis
Sgravenhage, Netherlands
North Shore Hospital
Auckland, New Zealand
Auckland City Hospital
Auckland, New Zealand
Health New Zealand Canterbury
Christchurch, New Zealand
Dunedin Hospital
Dunedin, New Zealand
Wellington Regional Hospital (Ccdhb)
Wellington, New Zealand
Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny
Brzozów, Poland
Pratia Onkologia Katowice
Katowice, Poland
Pratia McM Krakow
Krakow, Poland
Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie
Lublin, Poland
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
Wroclaw, Poland
Coltea Clinical Hospital
Bucharest, Romania
Institutul Clinic Fundeni
Bucureti, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
ClujNapoca, Romania
Seoul National University Bundang Hospital
Seongnam-si, South Korea
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, South Korea
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center
SongpaGu, South Korea
Hospital Universitario Virgen de Las Nieves
Granada, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain
Hospital Clinico Universitario Virgen de La Arrixaca
Murcia, Spain
Karolinska Universitetssjukhuset Solna
Stockholm, Sweden
University Hospitals Dorset Royal Bournemouth Hospital
Bournemouth, United Kingdom
Kings College Hospital
London, United Kingdom
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Norwich, United Kingdom
Trial contact
Study Director
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/11/2026.
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