Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd) compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2) positive advanced or metastatic lung cancer without actionable genomic alterations (AGA).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjenci z rakiem płuca (nie drobnokomórkowym) w zaawansowanym stadium (IIIB, IIIC lub IV), który rozprzestrzenił się lub jest nieoperacyjny.
- •Pacjenci, u których nie stwierdzono pewnych specyficznych zmian genetycznych w komórkach raka (np. EGFR, ALK, ROS1, NTRK, BRAF, RET, MET, KRAS G12C, HER2), które mogłyby być leczone innymi, dostępnymi lekami.
- •Pacjenci, u których poziom białka TROP2 w komórkach nowotworowych jest dodatni.
- •Pacjenci, u których choroba postąpiła pomimo lub po ostatnim leczeniu raka płuca.
- •Pacjenci, którzy otrzymali chemioterapię opartą na platynie w połączeniu z lekiem przeciw PD-1/PD-L1, lub te dwa rodzaje leczenia stosowane kolejno jako jedyne dotychczasowe terapie.
- •Pacjenci, którzy mogą dostarczyć próbkę tkanki guza do badań, aby potwierdzić poziom TROP2.
- •Pacjenci z co najmniej jedną zmianą widoczną w badaniach obrazowych (np. tomografia komputerowa), która nie była wcześniej leczona promieniowaniem i spełnia określone kryteria wielkości.
✗ Disqualifies
- •Pacjenci, u których zdiagnozowano drobnokomórkowego raka płuca.
- •Pacjenci, u których wykryto inne, możliwe do leczenia celowanymi terapiami zmiany genetyczne.
- •Pacjenci, którzy otrzymali w przeszłości określone rodzaje leczenia, które mogłyby wpłynąć na wyniki badania.
- •Pacjenci z innymi poważnymi chorobami, które mogłyby utrudnić udział w badaniu lub wpłynąć na jego wyniki.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (205)
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Chandler, United States
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Gilbert, United States
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Goodyear, United States
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Duarte, United States
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Irvine, United States
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La Jolla, United States
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Loma Linda, United States
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Los Angeles, United States
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San Diego, United States
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Grand Junction, United States
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Wheat Ridge, United States
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Newark, United States
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Washington D.C., United States
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Fort Myers, United States
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Jacksonville, United States
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St. Petersburg, United States
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Tampa, United States
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West Palm Beach, United States
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Marietta, United States
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Newnan, United States
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Chicago, United States
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Chicago, United States
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Niles, United States
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Zion, United States
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Louisville, United States
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South Portland, United States
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Baltimore, United States
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Brandywine, United States
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Boston, United States
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Detroit, United States
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Rochester, United States
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Bridgeton, United States
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Columbia, United States
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Lincoln, United States
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Albuquerque, United States
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East Syracuse, United States
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Portland, United States
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Hershey, United States
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Lancaster, United States
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Greenville, United States
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Memphis, United States
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Austin, United States
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Denton, United States
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Plano, United States
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Charlottesville, United States
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Fairfax, United States
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Williamsburg, United States
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Tacoma, United States
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Morgantown, United States
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Eau Claire, United States
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Gosford, Australia
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Kogarah, Australia
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South Brisbane, Australia
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St Albans, Australia
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Wollongong, Australia
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Graz, Austria
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Linz, Austria
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Rankweil, Austria
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Vienna, Austria
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Vienna, Austria
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Hasselt, Belgium
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La Louvière, Belgium
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Libramont-Chevigny, Belgium
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Sint-Niklaas, Belgium
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Yvoir, Belgium
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Salvador, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Vancouver, Canada
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Moncton, Canada
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Halifax, Canada
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Brampton, Canada
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Hamilton, Canada
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Toronto, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Jiamusi, China
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Jinan, China
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Nanchang, China
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Nanjing, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shantou, China
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Shenyang, China
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Tianjin, China
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Wuhan, China
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Wuhan, China
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Xuzhou, China
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Zhengzhou, China
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Zhengzhou, China
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Boulogne-Billancourt, France
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Lyon, France
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Marseille, France
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Saint-Herblain, France
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Toulouse, France
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Bad Saarow, Germany
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Bielefeld, Germany
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Bonn, Germany
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Cologne, Germany
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Essen, Germany
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Frankfurt, Germany
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Freiburg im Breisgau, Germany
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Gauting, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Krefeld, Germany
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Minden, Germany
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Oldenburg, Germany
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Stuttgart, Germany
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Troisdorf, Germany
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Velbert, Germany
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Debrecen, Hungary
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Gyöngyös - Mátraháza, Hungary
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Győr, Hungary
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Gyula, Hungary
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Kecskemét, Hungary
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Szolnok, Hungary
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Törökbálint, Hungary
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Bangalore, India
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Kolkata, India
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Mumbai, India
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Nashik, India
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New Delhi, India
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Milan, Italy
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Milan, Italy
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Monza, Italy
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Orbassano, Italy
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Padova, Italy
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Rozzano, Italy
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Chūōku, Japan
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Fukuoka, Japan
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Hiroshima, Japan
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Iwakuni-shi, Japan
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Kashiwa, Japan
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Kawasaki-shi, Japan
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Kyoto, Japan
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Matsuyama, Japan
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Nagoya, Japan
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Niigata, Japan
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Osaka, Japan
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Osakasayama-shi, Japan
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Sendai, Japan
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Sunto-gun, Japan
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Yokohama, Japan
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Lodz, Poland
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Olsztyn, Poland
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Poznan, Poland
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Warsaw, Poland
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Goyang-si, South Korea
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Incheon, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Suwon, South Korea
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A Coruña, Spain
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Barcelona, Spain
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L'Hospitalet de Llobregat, Spain
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Madrid, Spain
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Málaga, Spain
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Seville, Spain
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Zaragoza, Spain
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Hat Yai, Thailand
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Muang, Thailand
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Ankara, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Huddersfield, United Kingdom
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London, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Maidstone, United Kingdom
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Norwich, United Kingdom
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Stoke-on-Trent, United Kingdom
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Hanoi, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Vinh, Vietnam
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.