A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients with non-small cell lung cancer (NSCLC) who have remaining lymph node cancer after surgery. Radiation therapy uses high-energy X-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Intensity-modulated radiation therapy is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Adding I²-PORT radiation therapy to standard therapy may be more effective than standard therapy alone in reducing the risk of cancer returning in those who have undergone surgery for NSCLC.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent ma niedrobnokomórkowego raka płuca.
- •Rak płuca został wykryty w węzłach chłonnych po operacji.
- •Pacjent przeszedł operację płuca lub usunięcie większej części płuca.
- •Pacjent ma od 18 lat wzwyż.
- •Stan ogólny pacjenta pozwala na dalsze leczenie.
✗ Disqualifies
- •Rak płuca z przerzutami w inne części ciała.
- •Pacjent miał wcześniej radioterapię płuc lub śródpiersia.
- •Pacjentka w ciąży lub planująca ciążę (ze względu na wpływ radioterapii na płód).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (74)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, United States
OSF Saint Joseph Medical Center
Bloomington, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Illinois CancerCare-Carthage
Carthage, United States
Rush MD Anderson Cancer Center
Chicago, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Illinois CancerCare-Eureka
Eureka, United States
Illinois CancerCare-Galesburg
Galesburg, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Illinois CancerCare-Macomb
Macomb, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
OSF Saint Francis Radiation Oncology at Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, United States
OSF Saint Francis Medical Center
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Illinois CancerCare - Washington
Washington, United States
MaineHealth Coastal Cancer Treatment Center
Bath, United States
MaineHealth Cancer Care and IV Therapy - Brunswick
Brunswick, United States
MaineHealth Maine Medical Center - Portland
Portland, United States
MaineHealth Cancer Care Center of York County
Sanford, United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, United States
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health Medical Center - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health Medical Center - Canton
Canton, United States
Chelsea Hospital
Chelsea, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Sanford Joe Lueken Cancer Center
Bemidji, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Cancer Center
Duluth, United States
Essentia Health Saint Mary's Medical Center
Duluth, United States
Miller-Dwan Hospital
Duluth, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Essentia Health Sandstone
Sandstone, United States
Essentia Health Virginia Clinic
Virginia, United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, United States
Saint Francis Medical Center
Cape Girardeau, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
New York Proton Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Montefiore Medical Center-Einstein Campus
The Bronx, United States
Montefiore Medical Center - Moses Campus
The Bronx, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
Sanford Bismarck Medical Center
Bismarck, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, United States
Duluth Clinic Ashland
Ashland, United States
Northwest Wisconsin Cancer Center
Ashland, United States
Essentia Health-Hayward Clinic
Hayward, United States
Essentia Health-Spooner Clinic
Spooner, United States
Essentia Health Saint Mary's Hospital - Superior
Superior, United States
Trial contact
Amanda Clark
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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