RecruitingPhase IIEN originalGastric cancerMetastatic / advanced

PDL1/TGFβ In Combination With SHR2554 or Apatinib And Chemotherapy For First - Line Treatment Of Gastric Cancer

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

Immunotherapy combined with chemotherapy has become the standard first-line treatment regimen for gastric cancer. However, a subset of patients still fail to benefit or derive only limited benefit from this approach. This study aims to evaluate the addition of immunomodulatory EZH2 inhibitors or anti-angiogenic agents to the baseline regimen of immunotherapy combined with chemotherapy, in order to further improve patient treatment benefits.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • •Wiek 18 lat lub więcej
  • •Potwierdzony rozpoznaniem nowotworu żołądka lub przejścia przełyku do żołądka
  • •Zaawansowany rak (stadium III-IV), który nie może być operacyjnie usunięty lub dał przerzuty
  • •Nigdy wcześniej nie otrzymywał leczenia systemowego (chemii) na zaawansowanego raka
  • •Możliwość zmierzenia zmian nowotworowych w badaniach obrazowych
  • •Wystarczająco dobry stan zdrowia ogólnego i wyniki badań krwi

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
September 1, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (1)

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, China

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/2/2026.

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