PTEN and Organ-Specific microRNAs in Metastatic Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This prospective observational study aims to evaluate serum levels of PTEN, a tumor suppressor gene, and organ-specific microRNAs (miRNAs) associated with metastatic patterns in breast cancer. Serum samples will be analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR)-based miRNA profiling and enzyme-linked immunosorbent assay (ELISA)-based PTEN quantification. Three groups will be included: patients with metastatic breast cancer (n=80), patients with non-metastatic early-stage breast cancer (n=40), and healthy controls (n=40). The primary objective is to identify serum biomarkers that differentiate metastatic from non-metastatic disease. Secondary analyses will evaluate correlations between biomarker levels and organ-specific metastatic involvement, including bone, lung, liver, and brain metastases. Findings from this study may support the development of a noninvasive serum-based tool for predicting metastatic patterns in breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobiety w wieku 18 lat i starsze.
- •Zgoda na udział w badaniu.
- •Rak piersi z potwierdzonymi przerzutami do innych narządów (grupa I).
- •Rak piersi bez przerzutów do innych narządów (grupa II).
- •Zdrowe kobiety bez chorób piersi (grupa III).
✗ Disqualifies
- •Inne choroby nowotworowe w przeszłości.
- •Poważne problemy z wątrobą, nerkami lub krwią.
- •Przyjmowanie leków osłabiających odporność.
- •Ciąża lub karmienie piersią.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- January 27, 2026
- Sex
- Female only
Locations (1)
Atlas University Faculty of Medicine
Istanbul, Turkey (Türkiye)
Trial contact
Emine Yildirim, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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