Phase 1 Study of CLR 125 in Triple Negative Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to evaluate the safety and efficacy of 3 different dose levels of CLR 125 in patients with advanced triple negative breast cancer. The main questions the study aims to answer are: * What dose and regimen should be used in future trials of CLR 125 in patients with advanced triple negative breast cancer. * What side effects do participants have when taking CLR 125. Participants will: * Have CLR 125 administered via infusion 4 times each cycle; repeated every 8 weeks. * Visit the clinic once every 3 weeks for checkups and testing. * Report any side effects or new medications. Some participants may also receive one dose of CLR 131 to evaluate the amount of radiation delivered to various organs and to the tumor. These participants will: * Have 4 scans completed over 2 weeks * Have blood drawn 6 times over 2 weeks.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona raka piersi potrójnie ujemnego (brak receptorów estrogenowych, progesteronowych i HER2)
- •Wcześniejsze leczenie nie przyniosło poprawy - pacjent otrzymał przynajmniej jeden schemat chemioterapii lub innego leczenia
- •Wiek co najmniej 18 lat
- •Ogólny stan zdrowia pozwalający na uczestnictwo (skalę ECOG 0-2)
- •Oczekiwana długość życia co najmniej 6 miesięcy
- •Wystarczające wyniki badań krwi i funkcja nerek oraz wątroby
- •Co najmniej jeden widoczny guz wielkości co najmniej 10 mm
- •Zgoda na uczestnictwo w badaniu i przyjmowanie leku przez 12 miesięcy po włączeniu go do badania (dla kobiet) lub przez 12 miesięcy dla mężczyzn
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 3, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (4)
Mayo Clinic Florida
Jacksonville, United States
United Theranostics
Glen Burnie, United States
Mayo Clinic Rochester
Rochester, United States
United Theranostics
Princeton, United States
Trial contact
Kate Oliver
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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