A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible. After surgery, people may receive chemotherapy. After chemotherapy, standard care options may include: * Maintenance treatment, which is used after another therapy to keep the cancer from growing, spreading, or coming back. Bevacizumab is a targeted therapy used as standard maintenance treatment. Targeted therapy works to control how specific types of cancer cells grow and spread. * Observation, which is watching to see if cancer grows or worsens The study medicine, sacituzumab tirumotecan (also called sac-TMT), is a targeted therapy. The goal of this study is to learn if people who receive sac-TMT maintenance treatment with or without bevacizumab live longer without the cancer getting worse than people who receive standard care.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Choroba została potwierdzona badaniem tkanki.
- •Pacjent przeszedł operację usunięcia nowotworu.
- •Pacjent zakończył pierwszy etap leczenia chemioterapią.
- •Dostarczono tkankę guza, która nie była wcześniej naświetlana.
- •Jeśli pacjent ma HIV, choroba jest dobrze kontrolowana leczeniem.
✗ Disqualifies
- •Choroba jest innego rodzaju niż rak jajnika, otrzewnej lub jajowodu.
- •Choroba dała przerzuty do mózgu lub opon mózgowych.
- •Pacjent miał w przeszłości poważne problemy z oczami.
- •Pacjent ma problemy z jelitami wymagające leczenia lekami osłabiającymi odporność.
- •Pacjent przeszedł inne leczenie przeciwnowotworowe poza pierwszym etapem chemioterapii.
- •Pacjent miał w ostatnim czasie szczepionkę zawierającą żywe wirusy/bakterie.
- •Pacjent ma inną aktywnie postępującą chorobę nowotworową.
- •Pacjent ma aktywną infekcję wymagającą leczenia.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 21, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (155)
University of Alabama - Birmingham ( Site 0058)
Birmingham, United States
John Muir Health Cancer Center ( Site 0069)
Walnut Creek, United States
Mount Sinai Cancer Center ( Site 0029)
Miami Beach, United States
Orlando Health Winnie Palmer Hospital for Women and Babies ( Site 0085)
Orlando, United States
Winship Cancer Institute of Emory University ( Site 0037)
Atlanta, United States
Illinois Cancer Specialists (ICS) ( Site 8009)
Arlington Heights, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0055)
Fort Wayne, United States
Women's Cancer Care ( Site 0018)
Covington, United States
Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0060)
Scarborough, United States
Maryland Oncology Hematology, P.A. ( Site 8002)
Columbia, United States
Nebraska Methodist Hospital ( Site 0004)
Omaha, United States
University Of Nebraska Medical Center ( Site 0035)
Omaha, United States
The Center of Hope ( Site 0025)
Reno, United States
Womens Cancer Care Associates, LLC ( Site 0023)
Albany, United States
Duke Cancer Center ( Site 0012)
Durham, United States
University of Cincinnati Medical Center ( Site 0042)
Cincinnati, United States
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0007)
Tulsa, United States
Women & Infants Hospital ( Site 0001)
Providence, United States
West Cancer Center and Research Institute ( Site 0013)
Germantown, United States
University of Tennessee Medical Center ( Site 0087)
Knoxville, United States
Henry-Joyce Cancer Clinic ( Site 0011)
Nashville, United States
Virginia Cancer Specialists (VCS) ( Site 8012)
Fairfax, United States
Virginia Oncology Associates (VOA) ( Site 8013)
Norfolk, United States
Hospital Aleman ( Site 2903)
Ciudad Autonoma de Buenos Aires, Argentina
Instituto Alexander Fleming ( Site 2902)
Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
Mar del Plata, Argentina
Fundación Respirar ( Site 2912)
Buenos Aires, Argentina
Sanatorio Parque - Oncología ( Site 2911)
Rosario, Argentina
Instituto de Oncologia de Rosario ( Site 2909)
Rosario, Argentina
Hospital Britanico de Buenos Aires ( Site 2905)
CABA, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 2907)
La Rioja, Argentina
Westmead Hospital ( Site 0201)
Westmead, Australia
Gallipoli Medical Research Ltd ( Site 0204)
Brisbane, Australia
Epworth Freemasons ( Site 0207)
East Melbourne, Australia
Medizinische Universitat Wien ( Site 0102)
Vienna, Austria
Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0101)
Innsbruck, Austria
Grand Hopital de Charleroi ( Site 0303)
Charleroi, Belgium
AZ Maria Middelares ( Site 0302)
Ghent, Belgium
UZ Leuven ( Site 0301)
Leuven, Belgium
Obras Sociais Irma Dulce ( Site 0427)
Salvador, Brazil
Liga Norte Riograndense Contra o Cancer ( Site 0417)
Natal, Brazil
Hospital São Lucas da PUCRS ( Site 0415)
Porto Alegre, Brazil
ANIMI - Unidade de Tratamento Oncologico ( Site 0421)
Lages, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0414)
São José do Rio Preto, Brazil
CIUSSS - Saguenay-Lac-Saint-Jean ( Site 0519)
Chicoutimi, Canada
Centre Hospitalier de l'Université de Montréal ( Site 0518)
Montreal, Canada
McGill University Health Centre ( Site 0516)
Montreal, Canada
Clinica Puerto Montt ( Site 0606)
Port Montt, Chile
FALP ( Site 0607)
Santiago, Chile
Clínica Alemana de Santiago ( Site 0610)
Santiago, Chile
Pontificia Universidad Catolica de Chile ( Site 0602)
Santiago, Chile
ONCOCENTRO APYS-ACEREY ( Site 0603)
Viña del Mar, Chile
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0803)
Medellín, Colombia
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801)
Bogotá, Colombia
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0802)
Valledupar, Colombia
Instituto Nacional De Cancerologia ( Site 0808)
Bogota, Colombia
Oncólogos del Occidente S.A.S. ( Site 0806)
Pereira, Colombia
Fakultni Nemocnice Brno Bohunice ( Site 3304)
Brno, Czechia
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 3303)
Ostrava-Poruba, Czechia
Fakultni nemocnice Hradec Kralove ( Site 3307)
Hradec Králové, Czechia
Fakultni nemocnice Kralovske Vinohrady ( Site 3306)
Prague, Czechia
Vseobecna fakultni nemocnice v Praze ( Site 3305)
Prague, Czechia
Fakultni nemocnice motol ( Site 3302)
Prague, Czechia
Herlev Hospital ( Site 0902)
Herlev, Denmark
Aalborg Universitetshospital ( Site 0901)
Aalborg, Denmark
Aarhus Universitetshospital, Skejby ( Site 0903)
Aarhus, Denmark
Odense Universitets Hospital ( Site 0904)
Odense, Denmark
Oulun yliopistollinen sairaala ( Site 1003)
Oulu, Finland
Kuopion Yliopistollinen Sairaala ( Site 1004)
Kuopio, Finland
Tampereen yliopistollinen sairaala ( Site 1002)
Tampere, Finland
Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001)
Turku, Finland
CENTRE LEON BERARD ( Site 1101)
Lyon, France
Hopitaux Universitaires de Strasbourg ( Site 1109)
Strasbourg, France
Institut Paoli Calmettes ( Site 1111)
Marseille, France
Hôpital Privé Des Côtes d'Armor ( Site 1102)
Plérin, France
CHRU de Brest - Hopital de la Cavale Blanche ( Site 1104)
Brest, France
LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1114)
Toulouse, France
Centre Hospitalier Universitaire Dupuytren ( Site 1112)
Limoges, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau ( Site 1105)
Tours, France
Centre Oscar Lambret ( Site 1106)
Lille, France
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1113)
Clermont-Ferrand, France
Alexandra General Hospital of Athens ( Site 0703)
Athens, Greece
Evgenidion Clinic Agia Trias S.A ( Site 0701)
Athens, Greece
Agios Loukas Clinic ( Site 0702)
Thessaloniki, Greece
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 3910)
Kecskemét, Hungary
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 3911)
Győr, Hungary
Semmelweis Egyetem I. Szamu Szuleszeti es Nogyogyaszati Klinika ( Site 3915)
Budapest, Hungary
Országos Onkológiai Intézet-Ngyógyászat ( Site 3913)
Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 3912)
Debrecen, Hungary
St James Hospital ( Site 1302)
Dublin, Ireland
Rambam Health Care Campus ( Site 1422)
Haifa, Israel
Edith Wolfson Medical Center ( Site 1423)
Holon, Israel
Sheba Medical Center ( Site 1421)
Ramat Gan, Israel
Azienda Ospedaliera Spedali Civili di Brescia ( Site 1501)
Brescia, Italy
ASST DI LECCO ( Site 1509)
Lecco, Italy
Istituto Nazionale dei Tumori ( Site 1504)
Milan, Italy
Istituto Europeo di Oncologia ( Site 1503)
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1510)
Roma, Italy
Ospedale Mauriziano ( Site 1507)
Torino, Italy
Kurume University Hospital ( Site 1615)
Kurume, Japan
Gunma Prefectural Cancer Center ( Site 1605)
Ōta, Japan
Hokkaido University Hospital ( Site 1609)
Sapporo, Japan
Hyogo Cancer Center ( Site 1620)
Akashi, Japan
Iwate Medical University Hospital ( Site 1610)
Shiwa-gun, Japan
Saitama Medical University International Medical Center ( Site 1607)
Hidaka, Japan
Shizuoka Cancer Center ( Site 1618)
Sunto-gun,, Japan
Cancer Institute Hospital of JFCR ( Site 1614)
Koto, Japan
Keio University Hospital ( Site 1611)
Shinjyuku, Japan
National Hospital Organization Kyushu Cancer Center ( Site 1603)
Fukuoka, Japan
Kagoshima City Hospital ( Site 1613)
Kagoshima, Japan
Niigata Cancer Center Hospital ( Site 1608)
Niigata, Japan
Okayama University Hospital ( Site 1619)
Okayama, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1604)
Osaka, Japan
Stavanger Universitetssjukehus ( Site 2002)
Stavanger, Norway
Sorlandet Sykehus Kristiansand ( Site 2003)
Kristiansand, Norway
Oslo University Hospital ( Site 2001)
Oslo, Norway
Clínica San Felipe ( Site 3603)
Lima, Peru
Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 2106)
Poznan, Poland
Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 2105)
Poznan, Poland
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2102)
Siedlce, Poland
Bialostockie Centrum Onkologii ( Site 2104)
Bialystok, Poland
Uniwersytecki Szpital Kliniczny nr2 PUM w Szczecinie ( Site 2103)
Szczecin, Poland
Severance Hospital ( Site 2302)
Seodaemun-Gu, South Korea
Keimyung University Dongsan Hospital ( Site 2304)
Daegu, South Korea
Seoul National University Hospital ( Site 2301)
Seoul, South Korea
Asan Medical Center ( Site 2305)
Seoul, South Korea
Samsung Medical Center ( Site 2303)
Seoul, South Korea
Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
Girona, Spain
Complejo Hospitalario Universitario A Coruna ( Site 2412)
A Coruña, Spain
Clinica Universidad de Navarra ( Site 2407)
Madrid, Spain
Instituto Valenciano de Oncologia - IVO ( Site 2411)
Valencia, Spain
Hospital Vall D Hebron ( Site 2403)
Barcelona, Spain
Hospital Clinic I Provincial de Barcelona ( Site 2409)
Barcelona, Spain
ICO L Hospitalet ( Site 2408)
Barcelona, Spain
Hospital Universitario Reina Sofia ( Site 2406)
Córdoba, Spain
Hospital Ramon y Cajal ( Site 2405)
Madrid, Spain
Hospital Clinico San Carlos... ( Site 2410)
Madrid, Spain
Hospital Universitario La Paz-Oncología Médica ( Site 2404)
Madrid, Spain
Karolinska Universitetssjukhuset Solna ( Site 2502)
Stockholm, Sweden
Inselspital Bern ( Site 3504)
Bern, Switzerland
Ospedale Regionale Bellinzona e Valli ( Site 3501)
Bellinzona, Switzerland
Kantonsspital Graubünden ( Site 3503)
Chur, Switzerland
Hôpitaux Universitaires de Genève (HUG) ( Site 3502)
Geneva, Switzerland
Taichung Veterans General Hospital ( Site 2603)
Taichung, Taiwan
National Cheng Kung University Hospital ( Site 2602)
Tainan, Taiwan
National Taiwan University Hospital ( Site 2601)
Taipei, Taiwan
Mackay Memorial Hospital ( Site 2604)
Taipei, Taiwan
Linkou Chang Gung Memorial Hospital ( Site 2605)
Taoyuan, Taiwan
Ramathibodi Hospital. ( Site 3402)
Bangkok, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3401)
Bangkoknoi, Thailand
Faculty of Medicine - Khon Kaen University ( Site 3403)
Muang, Thailand
Addenbrookes Hospital ( Site 2802)
Cambridge, United Kingdom
University Hospitals of Leicester NHS Trust ( Site 2805)
Leicester, United Kingdom
University College London Hospitals ( Site 2801)
London, United Kingdom
The Christie NHS Foundation Trust ( Site 2804)
Manchester, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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