Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL). Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib is in a class of medications called kinase inhibitors. It blocks a protein called BTK, which is present on B-cell (a type of white blood cells) cancers such as mantel cell lymphoma at abnormal levels. This may help keep cancer cells from growing and spreading. Giving sonrotoclax and zanubrutinib may be more effective than zanubrutinib alone for the treatment of untreated CLL/SLL.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza CLL/SLL według międzynarodowych kryteriów.
- •Nieprawidłowo wysoka liczba białych krwinek (limfocytów B) we krwi.
- •Potrzeba leczenia zgodnie z wytycznymi, np. z powodu anemii, małej liczby płytek krwi.
- •Powiększona śledziona, powiększone węzły chłonne lub objawy ogólne (np. utrata wagi).
✗ Disqualifies
- •Wcześniejsze leczenie CLL/SLL.
- •Inne choroby nowotworowe.
- •Ciężkie problemy z nerkami lub wątrobą.
- •Przyjmowanie niektórych innych leków przeciwnowotworowych.
Simplified criteria — AI translation
Trial details
- Minimum age
- 65 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (152)
Cedars-Sinai Medical Center
Los Angeles, United States
Jupiter Medical Center
Jupiter, United States
Saint Alphonsus Cancer Care Center-Boise
Boise, United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Idaho Urologic Institute-Meridian
Meridian, United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Illinois CancerCare-Carthage
Carthage, United States
Northwestern University
Chicago, United States
Carle at The Riverfront
Danville, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Illinois CancerCare-Dixon
Dixon, United States
Carle Physician Group-Effingham
Effingham, United States
Illinois CancerCare-Eureka
Eureka, United States
Illinois CancerCare-Galesburg
Galesburg, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Illinois CancerCare-Macomb
Macomb, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Carle BroMenn Medical Center
Normal, United States
Carle Cancer Institute Normal
Normal, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Memorial Hospital East
Shiloh, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Carle Cancer Center
Urbana, United States
Illinois CancerCare - Washington
Washington, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Saint Anthony Regional Hospital
Carroll, United States
Mercy Hospital
Cedar Rapids, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, United States
UI Healthcare Mission Cancer and Blood - Pella
Pella, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
Cancer Center of Kansas - Chanute
Chanute, United States
Cancer Center of Kansas - Dodge City
Dodge City, United States
Cancer Center of Kansas - El Dorado
El Dorado, United States
Cancer Center of Kansas-Independence
Independence, United States
University of Kansas Cancer Center
Kansas City, United States
Cancer Center of Kansas-Kingman
Kingman, United States
Cancer Center of Kansas-Liberal
Liberal, United States
Cancer Center of Kansas - McPherson
McPherson, United States
Cancer Center of Kansas - Newton
Newton, United States
The University of Kansas Cancer Center - Olathe
Olathe, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
Cancer Center of Kansas - Parsons
Parsons, United States
Cancer Center of Kansas - Pratt
Pratt, United States
Cancer Center of Kansas - Salina
Salina, United States
University of Kansas Health System Saint Francis Campus
Topeka, United States
Cancer Center of Kansas - Wellington
Wellington, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, United States
Ascension Via Christi Hospitals Wichita
Wichita, United States
Cancer Center of Kansas - Wichita
Wichita, United States
Cancer Center of Kansas - Winfield
Winfield, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, United States
UofL Health Medical Center Northeast
Louisville, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
University of Michigan Health - Sparrow Lansing
Lansing, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Sanford Joe Lueken Cancer Center
Bemidji, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Mercy Hospital
Coon Rapids, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Cancer Center
Duluth, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Essentia Health Sandstone
Sandstone, United States
Essentia Health Virginia Clinic
Virginia, United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, United States
Saint Francis Medical Center
Cape Girardeau, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Parkland Health Center - Farmington
Farmington, United States
University of Kansas Cancer Center - Briarcliff
Kansas City, United States
University of Kansas Cancer Center - North
Kansas City, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Missouri Baptist Medical Center
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Missouri Baptist Sullivan Hospital
Sullivan, United States
Community Hospital of Anaconda
Anaconda, United States
Billings Clinic Cancer Center
Billings, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Logan Health Medical Center
Kalispell, United States
Community Medical Center
Missoula, United States
Jefferson Cherry Hill Hospital
Cherry Hill, United States
Sidney Kimmel Cancer Center Washington Township
Sewell, United States
University of Rochester
Rochester, United States
Wilmot Cancer Institute at Webster
Webster, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
Duke University Medical Center
Durham, United States
Margaret R Pardee Memorial Hospital
Hendersonville, United States
Sanford Bismarck Medical Center
Bismarck, United States
Essentia Health Cancer Center-South University Clinic
Fargo, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Saint Alphonsus Cancer Care Center-Baker City
Baker City, United States
Providence Newberg Medical Center
Newberg, United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, United States
Providence Willamette Falls Medical Center
Oregon City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Jefferson Torresdale Hospital
Philadelphia, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
Avera Cancer Institute at Yankton
Yankton, United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, United States
Swedish Cancer Institute-Edmonds
Edmonds, United States
Swedish Cancer Institute-Issaquah
Issaquah, United States
Swedish Medical Center-First Hill
Seattle, United States
Duluth Clinic Ashland
Ashland, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, United States
Gundersen Lutheran Medical Center
La Crosse, United States
William S Middleton VA Medical Center
Madison, United States
ProHealth D N Greenwald Center
Mukwonago, United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, United States
UW Cancer Center at ProHealth Care
Waukesha, United States
Trial contact
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.